Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug

Gangane, Purushottam; Mule, Vaibhav M.; Mahapatra, Debarshi Kar; Mahajan, Nilesh; Sawarkar, Harigopal S.

doi:10.31782/ijcrr.2021.131006

Cited by 2 publications

(5 citation statements)

References 8 publications

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“…Determination of drug content: Weighed quantities of sample (physical mixtures/solid dispersions) were dissolved in 10 ml of methanol kept in 10 ml volumetric flask. [25,26] The resulting mixture was diluted suitably and absorbance was measured at λmax 286 nm.…”

Section: Methodsmentioning

confidence: 99%

Design and Development of Fenofibrate Solid Dispersions for Solubility Enhancement

2022

pnr

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This research work designed to overcome the problems associated with poorly aqueous soluble drug. Fenofibrate (FENO) being BCS Class II drug shows low solubility but permeability is high. Compatibility of the drug and polymer studies was done by FTIR. Physical mixtures (PM) of the drug and polymer HPMCAS were prepared by trituration method. Fenofibrate solid dispersions (SD) were prepared by common solvent technique ascribed feasibility in laboratory scale. Physical state of formulations was characterized by powder XRD, TGA. Solubility of pure drug (FENO), Physical mixture and SD found to be 0.3, 0.78±0.15 to 1.15±0.28 and 2.17±0.37 to 3.25±0.14 mg/ml respectively. Percentage yield and percentage drug content were determined and found within satisfactory range. The maximum cumulative percentage of drug release from pure drug (FENO), Physical mixture and SD found to be 34.5%, 72.1 and 97.2% respectively at 60 minutes. Microscopy (SEM) study was found that the prepared solid dispersion has porous morphology. The present study establishes the increased bioavailability of the optimized batch when compared with the pure FENO. There was significant (50%) increase in absorption of Fenofibrate observed from the in vitro everted gut sac model. SD of FENO was developed successfully. The solubility of FENO was ameliorated significantly while compared with API (pure FENO). This research work found formulation of SD preferable technique to enhance solubility and enhance dissolution of lipophilic drugs.

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Section: Methodsmentioning

confidence: 99%

Design and Development of Fenofibrate Solid Dispersions for Solubility Enhancement

2022

pnr

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“…The produced SSDs were taken apart and accurately weighed in order to compute the production yield using the formula. 12…”

Section: Production Yieldmentioning

confidence: 99%

“…The resulting solution was suitably diluted and filtered, and the absorbance of the subsequent solution was measured at 286 nm using a UV spectrophotometer (UV-1800, Shimadzu). 12…”

Section: Drug Contentmentioning

confidence: 99%

“…As a result, SSDF6 and SSDF8 were chosen as the optimized batches, and samples from these batches were chosen for additional characterization and assessment. 12…”

Section: Production Yieldmentioning

confidence: 99%

“…The drug's partial amorphization in the dispersed state compared to its pure crystalline form, improved wettability, porosity, and increased surface area through dispersion could all be significant factors for solubility. 12 The hydrophilic properties of Aerosil 200 and CCS may be responsible for the improved solubility and dissolving rate of FNB in SSD.…”

Section: Saturation Solubilitymentioning

confidence: 99%

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Development and Evaluation of Fenofibrate Surface Solid Dispersion for Improved Solubility and Dissolution Rate

Hosmani,

Patil,

Pawar

et al. 2024

Ind. J. Pharm. Edu. Res

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Objectives:The current work aimed to prepare and characterize Surface-Solid Dispersion (SSD) of Fenofibrate (FNB) in order to improve its solubility and dissolution. Materials and Methods: SSD of FNB has been prepared using solvent evaporation techniques through the combination of hydrophilic polymers such as Aerosil 200, Avicel PH 101, Sodium Starch Glycolate (SSG), Crospovidone (CP) and Croscarmellose Sodium (CCS). The produced SSDs were tested for saturation solubility, production yield, Fourier-Transform Infrared Spectroscopy (FTIR), Powder X-ray Diffraction (PXRD), Differential Scanning Calorimetry (DSC), Scanning Electron Microscopy (SEM), and in vitro dissolution study. Results: PXRD results demonstrated a conversion of the crystalline FNB to an amorphous state when formulated with the carrier, which improved FNB solubility. A decrease in the endothermic peak with respect to FNB in the DSC thermogram of SSD, confirms the loss of crystallinity. Hydrophilic carriers such as Aerosil 200 and CCS at 1:2 (drug: polymer) ratios were found to increase solubility by 3 fold. Conclusion: As a result, the creation of SSD using hydrophilic polymers (Aerosil 200 and CCS) by solvent evaporation seemed to be a novel method that enhanced FNB solubility and dissolution.

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Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug

Cited by 2 publications

References 8 publications

Design and Development of Fenofibrate Solid Dispersions for Solubility Enhancement

Design and Development of Fenofibrate Solid Dispersions for Solubility Enhancement

Development and Evaluation of Fenofibrate Surface Solid Dispersion for Improved Solubility and Dissolution Rate

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