Development of fermented rice cake containing strawberry showing anti-inflammatory effect on LPS-stimulated macrophages and paw edema induced mice

Abstract

Strawberry (Fragaria ananassa) is one of the richest sources containing a wide variety of nutritive compounds. Anti-inflammatory activities of fermented rice cake made of strawberry powder as well as rice powder were evaluated. The fermented rice cake containing strawberry powder (SRC) significantly and dose-dependently inhibited NO production in LPS-stimulated RAW264.7 cells without cytotoxicity. Also, SRC effectively suppressed inflammatory gene expression, including iNOS, COX-2, IL-1β, IL-6, and TNF-α. In addition, the production of PGE2, IL-1β, IL-6, and TNF-α was significantly reduced. Furthermore, the anti-inflammatory effect of SRC was investigated using carrageenan-induced paw edema of ICR mice. It was demonstrated that pre-orally administration of SRC at a dose of 50 and 100 mg/kg BW significantly inhibited paw edema induced by carrageenan. This study suggested that the anti-inflammation activities of strawberry rice cake give the potential for increasing the commercialization of rice cake and rice products.

Comparative anti‐inflammatory effect of extract from novel Korean strawberry cultivars (Fragaria × ananassa) on lipopolysaccharide‐induced RAW264.7 macrophages and mouse model

“…CN7 extract showed the strongest inhibition, with an 82% change relative to the LPS-induced control (400 μg mL −1 ). The marked effect of strawberries in reducing the expression of the inflammatory gene COX-2 in LPS-induced macrophages was supported by a study conducted by Monmai et al, 24 where strawberry supplementation improved the anti-inflammatory activity of fermented rice cake compared to the effect of fermented rice alone.…”

Exploring the anti-inflammatory and antimicrobial potential of smilax zeylanica extract through in vivo and in vitro analysis

“…A potential alternative source for the Ayurveda medicine chopachine is Smilax zeylanica [5] . Many bioactivities, including antibacterial [6] , antioxidant [7] , cytotoxic [7] , analgesic [6] , antiepileptic [8] , antipyretic [9] , anticonvulsant [9] , antidiabetic [10] , cytoprotective [11] properties were reported from the plant. The goal of the current study was to evaluate the phytoconstituent and anti-microbial of an ethanolic extract of dried and powdered S. zeylanica leaves.…”