Development of Ga-68 labeled, biotinylated thiosemicarbazone dextran-coated iron oxide nanoparticles as multimodal PET/MRI probe

Gholipour, Nazila; Akhlaghi, Mehdi; Kheirabadi, Amin Mokhtari; Geramifar, Parham; Beiki, Davood

doi:10.1016/j.ijbiomac.2020.01.208

Cited by 30 publications

(12 citation statements)

References 73 publications

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“…[ 68 Ga]Ga-MagP-NODAGA and [ 68 Ga]Ga-MagP MIONs, with hydrodynamic diameters of 108 and 87 nm, respectively, follow the behavior of nanoparticles of similar size [ 5 , 52 ]. It is also reported that high negative nanoparticle surface charge may bring about more interactions with macrophages; thus, the surface charge of MIONs (−36 mV, at pH 7) may account for their high accumulation in MPS organs [ 30 , 53 ]. While the presence of the hydrophilic p(MAA-g-EGMA) coating resulted in their high colloidal stability in vitro, it did not inhibit uptake of these nanostructures in MPS organs in vivo, indicating that a higher molecular weight PEG is probably needed for effective steric stabilization of these MIONs in vivo.…”

Section: Resultsmentioning

confidence: 99%

“…Several studies propose that the decorating of nanostructures with targeting molecules presents improved tumor retention [ 30 , 57 ]. Thus, the functionalization of MIONs with ligands that recognize specific tumor targets could grant higher tumor accumulation to provide a better imaging performance.…”

Section: Resultsmentioning

confidence: 99%

“…The delivery of MIONs to tumors is achieved mainly by active and passive targeting. For active targeting, the particle surface is functionalized with ligands (small molecules, peptides, monoclonal antibodies) that recognize specific molecular cancer targets [ 18 , 29 , 30 , 31 ]. Passive tumor targeting is based on the enhanced permeability and retention effect (EPR), which comprises the extravasation of nanoparticles through the intercellular pores of tumor vessels (leaky vasculature) and their retention in tumor interstitial space due to the abnormally poor lymphatic drainage [ 32 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

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Chelator-Free/Chelator-Mediated Radiolabeling of Colloidally Stabilized Iron Oxide Nanoparticles for Biomedical Imaging

et al. 2021

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The aim of this study was to develop a bioimaging probe based on magnetic iron oxide nanoparticles (MIONs) surface functionalized with the copolymer (p(MAA-g-EGMA)), which were radiolabeled with the positron emitter Gallium-68. The synthesis of the hybrid MIONs was realized by hydrolytic condensation of a single ferrous precursor in the presence of the copolymer. The synthesized MagP MIONs displayed an average Dh of 87 nm, suitable for passive targeting of cancerous tissues through the enhanced permeation and retention (EPR) effect after intravenous administration, while their particularly high magnetic content ascribes strong magnetic properties to the colloids. Two different approaches were explored to develop MIONs radiolabeled with 68Ga: the chelator-mediated approach, where the chelating agent NODAGA-NHS was conjugated onto the MIONs (MagP-NODAGA) to form a chelate complex with 68Ga, and the chelator-free approach, where 68Ga was directly incorporated onto the MIONs (MagP). Both groups of NPs showed highly efficient radiolabeling with 68Ga, forming constructs which were stable with time, and in the presence of PBS and human serum. Ex vivo biodistribution studies of [68Ga]Ga- MIONs showed high accumulation in the mononuclear phagocyte system (MPS) organs and satisfactory blood retention with time. In vivo PET imaging with [68Ga]Ga-MagP MIONs was in accordance with the ex vivo biodistribution results. Finally, the MIONs showed low toxicity against 4T1 breast cancer cells. These detailed studies established that [68Ga]Ga- MIONs exhibit potential for application as tracers for early cancer detection.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Chelator-Free/Chelator-Mediated Radiolabeling of Colloidally Stabilized Iron Oxide Nanoparticles for Biomedical Imaging

et al. 2021

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“…Various natural polymers such as dextran [ 59 , 60 ], chitosan [ 61 ], hyaluronic acid [ 62 ], starch [ 63 ], albumin [ 64 ], alginate [ 65 ], gelatin [ 66 ] and polydopamine [ 67 , 68 ] (see Table 4 ) have been used as coating materials for superparamagnetic iron oxide nanoparticles, also known in the literature as SPIONs, to reduce aggregation, enhance their stability and biocompatibility [ 27 ], features also mentioned above.…”

Section: Surface Shell Engineering Of Magnetic Materials For Imaging Purposesmentioning

confidence: 99%

Imaging Constructs: The Rise of Iron Oxide Nanoparticles

et al. 2021

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Over the last decade, an important challenge in nanomedicine imaging has been the work to design multifunctional agents that can be detected by single and/or multimodal techniques. Among the broad spectrum of nanoscale materials being investigated for imaging use, iron oxide nanoparticles have gained significant attention due to their intrinsic magnetic properties, low toxicity, large magnetic moments, superparamagnetic behaviour and large surface area—the latter being a particular advantage in its conjunction with specific moieties, dye molecules, and imaging probes. Tracers-based nanoparticles are promising candidates, since they combine synergistic advantages for non-invasive, highly sensitive, high-resolution, and quantitative imaging on different modalities. This study represents an overview of current advancements in magnetic materials with clinical potential that will hopefully provide an effective system for diagnosis in the near future. Further exploration is still needed to reveal their potential as promising candidates from simple functionalization of metal oxide nanomaterials up to medical imaging.

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“…Compared with non-biotinylated cells, its advantage was also reflected in its significantly enhanced affinity for biotin receptor-positive 4T1 cells. In PET-MRI medical examinations, the early detection of biotin receptor-positive tumors could be achieved using radiolabeled NPs [ 69 ].…”

Section: The Application Of the Mri Nanoprobementioning

confidence: 99%

The Design of Abnormal Microenvironment Responsive MRI Nanoprobe and Its Application

Wang

Han

et al. 2021

IJMS

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Magnetic resonance imaging (MRI) is often used to diagnose diseases due to its high spatial, temporal and soft tissue resolution. Frequently, probes or contrast agents are used to enhance the contrast in MRI to improve diagnostic accuracy. With the development of molecular imaging techniques, molecular MRI can be used to obtain 3D anatomical structure, physiology, pathology, and other relevant information regarding the lesion, which can provide an important reference for the accurate diagnosis and treatment of the disease in the early stages. Among existing contrast agents, smart or activatable nanoprobes can respond to selective stimuli, such as proving the presence of acidic pH, active enzymes, or reducing environments. The recently developed environment-responsive or smart MRI nanoprobes can specifically target cells based on differences in the cellular environment and improve the contrast between diseased tissues and normal tissues. Here, we review the design and application of these environment-responsive MRI nanoprobes.

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Development of Ga-68 labeled, biotinylated thiosemicarbazone dextran-coated iron oxide nanoparticles as multimodal PET/MRI probe

Cited by 30 publications

References 73 publications

Chelator-Free/Chelator-Mediated Radiolabeling of Colloidally Stabilized Iron Oxide Nanoparticles for Biomedical Imaging

Chelator-Free/Chelator-Mediated Radiolabeling of Colloidally Stabilized Iron Oxide Nanoparticles for Biomedical Imaging

Imaging Constructs: The Rise of Iron Oxide Nanoparticles

The Design of Abnormal Microenvironment Responsive MRI Nanoprobe and Its Application

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