Development of Gender Differences in DBA/2Cr Mouse Kidney Morphology during Maturation

Abstract

ABSTRACT. Although we recently clarified sex-based differences in mouse kidney morphology, the developmental processes responsible for these gender differences during maturation remain unclear. The present study analyzed the morphometry of kidneys from 20-, 30-, 50-, 60-, 70-, 90-, 120-and 150-day-old DBA/2Cr mice. Total kidney weight and ratio of kidney weight to body weight were larger in males than females beginning at 50 days of age. The percentage of renal corpuscles exhibiting a cuboidal parietal layer was higher in males than in females in the 70-day and older mice. The diameter of cortical renal corpuscles was larger in males than in females beginning on day 90. The number of proximal convoluted tubular cell nuclei was higher in females than in males from day 90 onward. Vacuolar structures in the proximal convoluted tubular epithelium became prominent in 70-day-old males. PAS-positive granules in the proximal straight tubular epithelium became prominent in females on day 50. This paper is the first to describe the development of gender differences in mouse kidney morphology.

Effects of dietary protein restriction on nephron number in the mouse

“…Female mice in our study had a significantly lower kidney and body weight than males, consistent with observations from previous studies (18,28). Brain weight, as a proportion of total body weight, was greater in female than male mice.…”

“…Total glomerular volume and total renal corpuscle volume was also found to be greater in female than in male mice. Two previous studies investigated sex differences in glomerular morphology in mice at a similar age yet failed to detect sex differences in renal corpuscle diameter or glomerular area (18,28), although neither study employed unbiased stereological techniques. Okada et al (28) found no sex differences in cortical corpuscle diameter in Fig.…”

The influence of interferon-γ on cardiac and renal histopathological changes induced by carbamazepine

“…Moreover, our study illustrated degeneration of convoluted tubules with infl ammatory infi ltrate cells of the fetal kidney in the CBZ group. This data is in line with Okada's (2005) study results that showed CBZ can lead to degeneration of the renal tubules and atrophy of the glomeruli (22). Furthermore, Takayasu (2010) confi rmed that concentrations of CBZ metabolites are much higher in the kidney, liver, lung, and brain than in the blood.…”

Mouse

“…The occurrence of cuboidal epithelium is influenced by gonadectomy, and as mice mature, the number of glomeruli with cuboidal epithelium increases (Yabuki et al 1999(Yabuki et al , 2003. In mice older than two years the incidence decreases (Okada et al 2005) (Fig. 4.60a & b).…”