2013
DOI: 10.1113/jphysiol.2013.263483
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Development of heart failure is independent of K+ channel‐interacting protein 2 expression

Abstract: Key points• Previous studies have suggested that the K + channel auxiliary subunit K + channel-interacting protein 2 (KChIP2) serves as a regulator of cardiac remodelling leading to heart failure and increased risk of arrhythmias.• The results presented here show that the progression of cardiac remodelling and heart failure induced by transverse aortic constriction follows a similar time course in wild-type and KChIP2 −/− mice.• Protein expression analysis shows that ventricular KChIP2 is significantly downreg… Show more

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Cited by 19 publications
(29 citation statements)
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“…We have previously documented that WT mice have a higher incidence of pacing‐induced ventricular arrhythmias than KChIP2 −/− mice (Speerschneider et al . ), corroborating other anti‐arrhythmic reports from different mouse models of I to,f downregulation (Brunner et al . , London et al .…”
Section: Discussionsupporting
confidence: 91%
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“…We have previously documented that WT mice have a higher incidence of pacing‐induced ventricular arrhythmias than KChIP2 −/− mice (Speerschneider et al . ), corroborating other anti‐arrhythmic reports from different mouse models of I to,f downregulation (Brunner et al . , London et al .…”
Section: Discussionsupporting
confidence: 91%
“…We have previously documented that WT mice have a higher incidence of pacing-induced ventricular arrhythmias than KChIP2 À/À mice (Speerschneider et al 2013), corroborating other anti-arrhythmic reports from different mouse models of I to,f downregulation (Brunner et al 2001, London et al 2007), but in clear conflict with the first report on KChIP2 À/À mice (Kuo et al 2001). In the previous study from our group, pacing was delivered from the LV endocardial site.…”
Section: Discussionsupporting
confidence: 85%
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“…The constitutive sympathetic activation could also play a direct or indirect role in the progression of HF and in the down‐regulation of I to,f . Ventricular expression of KChIP2 is decreased in patients with HF as well as in experimental models of hypertrophy …”
Section: Regional Heterogeneity Of Ventricular Action Potential Morphmentioning
confidence: 99%