Development of hydroxyapatite coatings on laser textured 316 LSS and Ti-6Al-4V and its electrochemical behavior in SBF solution for orthopedic applications

Stango, S. Arul Xavier; Karthick, D.; Swaroop, S.; Mudali, U. Kamachi; Vijayalakshmi, U.

doi:10.1016/j.ceramint.2017.11.083

Cited by 62 publications

(28 citation statements)

References 28 publications

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“…Although stainless steel implants are not commonly in use today, they have potential as coated biocompatible materials, as their regeneration time is higher than titanium or titanium alloys because they can possess a more stable passive layer. 13 , 23 Furthermore, the mesh characteristics were expected to affect HA coating and ECM coverage based on open areas and wire waviness patterns. After mechanical testing through nanoindentation on the flexible HA/metal mesh samples, biocompatibility tests were performed to observe adipose-derived stem cells (ASCs) attachment, proliferation and osteogenic differentiation.…”

Section: Introductionmentioning

confidence: 99%

Improved Biocompatible, Flexible Mesh Composites for Implant Applications via Hydroxyapatite Coating with Potential for 3-Dimensional Extracellular Matrix Network and Bone Regeneration

Naderi

Zhang

Belgodere

et al. 2021

ACS Appl. Mater. Interfaces

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Hydroxyapatite (HA)-coated metals are biocompatible composites, which have potential for various applications for bone replacement and regeneration in the human body. In this study, we proposed the design of biocompatible, flexible composite implants by using a metal mesh as substrate and HA coating as bone regenerative stimulant derived from a simple sol–gel method. Experiments were performed to understand the effect of coating method (dip-coating and drop casting), substrate material (titanium and stainless steel) and substrate mesh characteristics (mesh size, weave pattern) on implant’s performance. HA-coated samples were characterized by X-ray diffractometer, transmission electron microscope, field-emission scanning electron microscope, nanoindenter, polarization and electrochemical impedance spectroscopy, and biocompatibility test. Pure or biphasic nanorod HA coating was obtained on mesh substrates with thicknesses varying from 4.0 to 7.9 μm. Different coating procedures and number of layers did not affect crystal structure, shape, or most intense plane reflections of the HA coating. Moduli of elasticity below 18.5 GPa were reported for HA-coated samples, falling within the range of natural skull bone. Coated samples led to at least 90% cell viability and up to 99.5% extracellular matrix coverage into a 3-dimensional network (16.4% to 76.5% higher than bare substrates). Fluorescent imaging showed no antagonistic effect of the coatings on osteogenic differentiation. Finer mesh size enhanced coating coverage and adhesion, but a low number of HA layers was preferable to maintain open mesh areas promoting extracellular matrix formation. Finally, electrochemical behavior studies revealed that, although corrosion protection for HA-coated samples was generally higher than bare samples, galvanic corrosion occurred on some samples. Overall, the results indicated that while HA-coated titanium grade 1 showed the best performance as a potential implant, HA-coated stainless steel 316 with the finest mesh size constitutes an adequate, lower cost alternative.

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Section: Introductionmentioning

confidence: 99%

Improved Biocompatible, Flexible Mesh Composites for Implant Applications via Hydroxyapatite Coating with Potential for 3-Dimensional Extracellular Matrix Network and Bone Regeneration

Naderi

Zhang

Belgodere

et al. 2021

ACS Appl. Mater. Interfaces

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“…Nowadays, the main bone scaffold materials that are widely evaluated are non-degradable metal materials such as titanium and its alloys, 316 L stainless steel, etc. [9,10]. Contrary to metallic bone scaffolds, the bone scaffolds composed of biodegradable fiber bundle braids enable the osteocyte proliferates with the braids being decomposed.…”

Section: Introductionmentioning

confidence: 99%

Properties and Mechanism of Hydroxyapatite Coating Prepared by Electrodeposition on a Braid for Biodegradable Bone Scaffolds

Ling

Lin

et al. 2019

Nanomaterials

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Hydroxyapatite (HA) coating is successfully prepared by electrodeposition on the surface of polyvinyl alcohol (PVA)/polylactic acid (PLA) braid which serves as a potential biodegradable bone scaffold. The surface morphology, element composition, crystallinity and chemical bonds of HA coatings at various deposition times (60, 75, 90, 105 and 120 min) are characterized by scanning electron microscopy (SEM), energy dispersive X-ray analysis (EDAX), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR), respectively. Average Surface roughness (Ra) of HA coating is observed by confocal microscopy. The results reveal that the typical characteristic peaks of the FTIR spectrum confirm that HA coating is successfully prepared on the rugged surface of the PVA/PLA braid. The XRD results indicate that the crystallinity of HA can be improved by increasing deposition time. In the 90 min-deposition, hydroxyapatite has a dense and uniform coating morphology, Ca/P ratio of 1.7, roughness of 0.725 μm, which shows the best electrodeposition performance. The formation mechanism of granular and plate-like hydroxyapatite crystals is explained by the structural characteristics of a hydroxyapatite unit cell. This study provides a foundation for a bone scaffold braided by biodegradable fibers.

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“…Several techniques have been employed to deposit HAp on the Ti surfaces. 9,10 However, to deal with surface generation during machining, electric discharge machining (EDM) is a possible way forward, which has the competencies to develop biocompatible surface in order to augment bioactivity and other mechanical or chemical properties. [11][12][13] EDM, as a thermoelectric process, is an efficient surface-altering technique to process hard, temperature-resistant, and high-strength materials.…”

Section: Introductionmentioning

confidence: 99%

On the machinability and properties of Ti–6Al–4V biomaterial with n-HAp powder–mixed ED machining

Bains¹,

Bahraminasab

Sidhu³

et al. 2019

Proc Inst Mech Eng H

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Nano-hydroxyapatite powder was used in electric discharge machining to modify the surface of Ti–6Al–4V medical alloy. Herein, electric discharge machining was performed, with and without powder-mixed flushing for evaluation of the material erosion rate and surface roughness. In addition to dielectric type, several process parameters including current, pulse-on duration, pulse-off duration, and electrode hole diameter were considered. The experiments were planned by Taguchi design technique and conducted to analyze the material erosion rate and surface roughness. After machining, scanning electron microscope, energy-dispersive X-ray spectrometry, and X-ray diffraction techniques were used to evaluate the surfaces of the samples. Furthermore, wear and corrosion tests were also carried out on the Ti alloy with modified surfaces. The influential factors were identified based on analysis of variance results. Current and dielectric type were the significant factors, both for the material erosion rate and surface roughness. The scanning electron microscope images of Ti–6Al–4V samples highlighted that the process parameters exhibited a vital influence on the topology and microstructure of machined surface. Furthermore, energy-dispersive X-ray spectrometry and X-ray diffraction analyses confirmed the presence of hydroxyapatite on Ti alloy surface after machining. Moreover, the results of wear and corrosion tests revealed lower wear and corrosion rates of the surface-treated workpiece with nano-hydroxyapatite.

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Development of hydroxyapatite coatings on laser textured 316 LSS and Ti-6Al-4V and its electrochemical behavior in SBF solution for orthopedic applications

Cited by 62 publications

References 28 publications

Improved Biocompatible, Flexible Mesh Composites for Implant Applications via Hydroxyapatite Coating with Potential for 3-Dimensional Extracellular Matrix Network and Bone Regeneration

Improved Biocompatible, Flexible Mesh Composites for Implant Applications via Hydroxyapatite Coating with Potential for 3-Dimensional Extracellular Matrix Network and Bone Regeneration

Properties and Mechanism of Hydroxyapatite Coating Prepared by Electrodeposition on a Braid for Biodegradable Bone Scaffolds

On the machinability and properties of Ti–6Al–4V biomaterial with n-HAp powder–mixed ED machining

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