Development of microbial resistant thermosensitive Ag nanocomposite (gelatin) hydrogels via green process

Manjula, B.; Varaprasad, Kokkarachedu; Sadiku, Rotimi; Ramam, Koduri; Reddy, G. Venkata; Raju, K. Mohana

doi:10.1002/jbm.a.34780

Cited by 22 publications

(13 citation statements)

References 26 publications

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“…61,62 Poly(N-isopropylacrylamide) (PNIPAM) is the second commonly used matrix in Ag NP hydrogels. James et al, 63 Manjula et al 64 and Zafar et al 65 used PNIPAM as a main component to synthesize Ag NP hydrogels. James et al 63 synthesized PNIPAM-co-allylamine nanogels and grafted them onto non-woven polypropylene.…”

Section: Sliver Nanoparticles (Ag Nps)mentioning

confidence: 99%

“…James et al 63 synthesized PNIPAM-co-allylamine nanogels and grafted them onto non-woven polypropylene. Hydrogels made by Manjula et al 64 were reduced with neem leaf (Azadirachta indica) extracts, providing another green process. During the fabrication, emphasis was placed on green techniques, in order to make it environmentally friendly.…”

Section: Sliver Nanoparticles (Ag Nps)mentioning

confidence: 99%

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Antimicrobial hydrogels: promising materials for medical application

Yang

Han

Chen

et al. 2018

IJN

319

230

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The rapid emergence of antibiotic resistance in pathogenic microbes is becoming an imminent global public health problem. Local application of antibiotics might be a solution. In local application, materials need to act as the drug delivery system. The drug delivery system should be biodegradable and prolonged antibacterial effect should be provided to satisfy clinical demand. Hydrogel is a promising material for local antibacterial application. Hydrogel refers to a kind of biomaterial synthesized by a water-soluble natural polymer or a synthesized polymer, which turns into gel according to the change in different signals such as temperature, ionic strength, pH, ultraviolet exposure etc. Because of its high hydrophilicity, unique three-dimensional network, fine biocompatibility and cell adhesion, hydrogel is one of the suitable biomaterials for drug delivery in antimicrobial areas. In this review, studies from the past 5 years were reviewed, and several types of antimicrobial hydrogels according to different ingredients, different preparations, different antimicrobial mechanisms, different antimicrobial agents they contained and different applications, were summarized. The hydrogels loaded with metal nanoparticles as a potential method to solve antibiotic resistance were highlighted. Finally, future prospects of development and application of antimicrobial hydrogels are suggested.

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Section: Sliver Nanoparticles (Ag Nps)mentioning

confidence: 99%

Section: Sliver Nanoparticles (Ag Nps)mentioning

confidence: 99%

Antimicrobial hydrogels: promising materials for medical application

Yang

Han

Chen

et al. 2018

IJN

319

230

View full text Add to dashboard Cite

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“…The swelling behavior of hydrophilic hydrogel samples were measured at room temperature, using a swelling method . The completely dried hydrogels were immersed in a 100 mL beaker containing twice distilled water until their weight became constant (24 h).…”

Section: Methodsmentioning

confidence: 99%

Development of microbial protective Kolliphor‐based nanocomposite hydrogels

Varaprasad¹,

Sadiku

2015

J of Applied Polymer Sci

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In this scientific work, a novel class of antimicrobial nanocomposite hydrogels were designed and synthesized by chemical and environmentally bioprocess using Kolliphor, acrylamide, and mint leafs in order to achieve antiseptic property for wound applications. In the bioprocess approach, silver nitrate and gold chloride were nucleated with mint leafs in order to obtain effective free individual nano-inorganic compounds to provide superior antibacterial assets. The formations of dual inorganic nanoparticles were confirmed by transmission electron microscopy, which indicated the size of nanoparticles in the range of approximately 3 6 2 nm and without agglomeration. The formations of biomaterials were characterized using Fourier transform infrared spectroscopy, thermogravimetric analysis, scanning electron microscopic-energy dispersive spectrometric studies and their swelling properties were determined. Furthermore, the pure hydrogel and the dual inorganic nanocomposite hydrogels developed were tested for antibacterial activities. When compared with the neat hydrogel, the nanocomposite hydrogels significantly improved their anti-bacterial activities on Bacillus bacterium.

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“…Such reducing agents have environmental effects and biologically toxicity, researchers are concentrating to use plant based reducing agents for their potentiality of non-polluted, environmentally acceptable materials concerning the human health. Among the various antibacterial agents, thermoresponsive/stimulisensitive biodegradable nanocomposite hydrogels have strong inhibitory and antibacterial activity [9,10] and also have many applications in medical world like gene therapy, cancer therapy, drug delivery etc.…”

Section: Introductionmentioning

confidence: 99%

Novel Thermoresponsive Biodegradable Nanocomposite Hydrogels for Dual Function in Biomedical Applications

Prabhakar

Sudhakara

Subha

et al. 2015

Polymer-Plastics Technology and Engineering

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Nano-composite hydrogels (NCH) were prepared through blend solution of Poly(lactic acid) (PLA) and Poly(N-isopropylacrylamide)-co-acrylamide (Poly(NIPAAm-co-AAm)) via free radical polymerization. Plant extractions were used for the synthesis of Ag nanoparticles to study the antibacterial activity of the hydrogels. Similarly, 5-Fluorouracil (5-FU) drug was loaded through both in-situ and ex situ methods to study the controlled release profiles. The NCH were characterized by UV, FT-IR, TGA-DSC, X-RD, SEM and TEM. Dissolution and agar diffusion test were performed to evaluate the drug release and antibacterial activity respectively. The results suggested that the fabricated NCH can be used as a promising candidate for dual function in bio-medical applications.Schematic diagram about the formation of silver loaded and drug loaded nano-composite hydrogels. Downloaded by [University of Otago] at 21:35 15 July 2015 2

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Development of microbial resistant thermosensitive Ag nanocomposite (gelatin) hydrogels via green process

Cited by 22 publications

References 26 publications

Antimicrobial hydrogels: promising materials for medical application

Antimicrobial hydrogels: promising materials for medical application

Development of microbial protective Kolliphor‐based nanocomposite hydrogels

Novel Thermoresponsive Biodegradable Nanocomposite Hydrogels for Dual Function in Biomedical Applications

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