Development of microfluidic-based cell collection devices for in vitro and in vivo use

Butt, Logan; Entenberg, David; Hemachandra, L. P. Madhubhani P.; Strohmayer, Matthew; Keely, Patricia J.; Aguirre‐Ghiso, Julio A.; Condeelis, John S.; Castracane, James

doi:10.1117/12.2213316

Cited by 1 publication

(1 citation statement)

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“…171 The nano-intravital device (NANIVID) is one implementation that has been used for an array of studies in vitro and in vivo including hydrogelmediated release of the chemotaxis agents (epidermal growth factor), hypoxia mimetics (deferoxamine and cobalt chloride), and ROS inductors (H 2 O 2 ), as well as for cell collection (Figure 3(a)-(h)). 166,[172][173][174][175] Further work in this direction has aimed at extending experiment duration through the integration of fluidic control with intravital imaging windows (ported mammary imaging window) (Figure 3(i)). 63,176 Recently, the development of integrated micro-nozzles for enhanced control over localized delivery has provided additional impetus for high resolution study in vivo (Figure 3(j)).…”

Section: Manipulation Of the Tmementioning

confidence: 99%

Monitoring and modulation of the tumor microenvironment for enhanced cancer modeling

Head

Cady

2022

Exp Biol Med (Maywood)

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Cancer treatments utilizing biologic or cytotoxic drugs compose the frontline of therapy, and though gains in treatment efficacy have been persistent in recent decades, much work remains in understanding cancer progression and treatment. Compounding this situation is the low rate of success when translating preclinical drug candidates to the clinic, which raises costs and development timelines. This underperformance is due in part to the poor recapitulation of the tumor microenvironment, a critical component of cancer biology, in cancer model systems. New technologies capable of both accurately observing and manipulating the tumor microenvironment are needed to effectively model cancer response to treatment. In this review, conventional cancer models are summarized, and a primer on emerging techniques for monitoring and modulating the tumor microenvironment is presented and discussed.

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