Development of modified apple polysaccharide capped silver nanoparticles loaded with mesalamine for effective treatment of ulcerative colitis

Kaur, Gurmandeep; Singh, Sachin Kumar; Kumar, Rajesh; Kumar, Bimlesh; Kumari, Yogita; Gulati, Monica; Pandey, Narendra Kumar; Kuppusamy, Gowthamarajan; Ghosh, Dipanjoy; Ayinkamiye, Clarisse; Wadhwa, Sheetu; Mehta, Meenu; Satija, Saurabh; Dua, Kamal; Dureja, Harish; Gupta, Shashank; Singh, Pankaj Kumar; Kapoor, Bhupinder; Chitranshi, Nitin; Kumar, Ankit; Porwal, Omji

doi:10.1016/j.jddst.2020.101980

Cited by 15 publications

(4 citation statements)

References 46 publications

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“…Results from acetic acid induced ulcerative colitis rat model showed effective therapeutic outcomes at higher doses of the drug loaded nanocarrier system as compared to low doses showing the efficacy of the afore mentioned nanosystem (Kaur et al. 2020 ). Similarly, Phragmites rhizoma polysaccharide selenium nanoparticles were developed and loaded with Azathioprine for targeting ulcerative colitis lesions.…”

Section: Conventional Nanocarriers Targeting Ulcerative Colitismentioning

confidence: 99%

Responsive nanosystems for targeted therapy of ulcerative colitis: Current practices and future perspectives

et al. 2023

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The pharmacological approach to treating gastrointestinal diseases is suffering from various challenges. Among such gastrointestinal diseases, ulcerative colitis manifests inflammation at the colon site specifically. Patients suffering from ulcerative colitis notably exhibit thin mucus layers that offer increased permeability for the attacking pathogens. In the majority of ulcerative colitis patients, the conventional treatment options fail in controlling the symptoms of the disease leading to distressing effects on the quality of life. Such a scenario is due to the failure of conventional therapies to target the loaded moiety into specific diseased sites in the colon. Targeted carriers are needed to address this issue and enhance the drug effects. Conventional nanocarriers are mostly readily cleared and have nonspecific targeting. To accumulate the desired concentration of the therapeutic candidates at the inflamed area of the colon, smart nanomaterials with responsive nature have been explored recently that include pH responsive, reactive oxygen species responsive (ROS), enzyme responsive and thermo – responsive smart nanocarrier systems. The formulation of such responsive smart nanocarriers from nanotechnology scaffolds has resulted in the selective release of therapeutic drugs, avoiding systemic absorption and limiting the undesired delivery of targeting drugs into healthy tissues. Recent advancements in the field of responsive nanocarrier systems have resulted in the fabrication of multi-responsive systems i.e. dual responsive nanocarriers and derivitization that has increased the biological tissues and smart nanocarrier’s interaction. In addition, it has also led to efficient targeting and significant cellular uptake of the therapeutic moieties. Herein, we have highlighted the latest status of the responsive nanocarrier drug delivery system, its applications for on–demand delivery of drug candidates for ulcerative colitis, and the prospects are underpinned.

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Section: Conventional Nanocarriers Targeting Ulcerative Colitismentioning

confidence: 99%

Responsive nanosystems for targeted therapy of ulcerative colitis: Current practices and future perspectives

et al. 2023

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“…So There are several people which claim herbalmedicines to be devoid of side effects that is amyth. There still are masses which still completelydepend on herbal medicine so much so that havereplaced the daily prescribed dose of allopathicfor diabetes, hypertension, thyroid disease, etc [87][88][89][90] with herbal medicines where the patient have pledged to have the medicines lifelong. There are several sites online which are trying to trade herbal medicines under the tag of being free from side effects.…”

Section: Overview Of the Use Of Plants In Dentistrymentioning

confidence: 99%

A Review on medicinal plants in dentistry

Porwal

Kala

2021

J. Drug Delivery Ther.

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The dental afflictions are indubitably the most important global infectious diseases affecting both children and adults. The most significant dental illness is dental caries and periodontal pathologies. The major reason of oral health troubles is more inhabitants with pathogenic bacteria and for this reason, conservative treatment can often be in efficient because of bacterial resistance or may have unpleasant side effects.For that reason, studies in the field have focused on finding new therapeutic alternatives.The use of natural medicines for dental care is an ancient cross-cultural practice that persists in the majority of cultures today.Over the past decade, interest in drugs derived from medicinal plants has markedly increased. This study was designed at a literature review focusing on studies investigating herbal drugs and their therapeutic application, mechanism of action, side effects, toxicities and probable drug interactions. A small number of studies were established to hold their rational employ in dentistry. Because there is a rising employ of phytotherapeutic agents in dentistry, additional studies are required to evaluate their safety and efficacy for clinical use. Keywords: Herbal medicine, Oral health, Dentistry, Caries, Infections

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“…Squalene) by melt-emulsification. NLCs have been explored as an alternative drug carrier combining the advantages of solid lipid nanoparticles with high encapsulation efficiency and reduced drug leakage [141][142][143][144][145][146][147][148][149] as a result of their lipophilic and bioadhesive properties. NLCs demonstrate increased residence in the lung and sustained release of the entrapped drug from the lipid matrices [150].…”

Section: Nanostructured Lipid Carriersmentioning

confidence: 99%

Advancing of Cellular Signaling Pathways in Respiratory Diseases Using Nanocarrier Based Drug Delivery Systems

Mehta

Dhanjal

Satija

et al. 2020

CPD

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: Cell Signaling pathways form an integral part of our existence, that allows the cells to comprehend a stimulus and respond back. Such reactions, to external cues from the environment, are required and are essential to regulate the normal functioning of our body. Abnormalities in the system arise when there are errors developed in these signals, resulting in a complication or a disease. Presently, respiratory diseases contribute to being the third leading cause of morbidity worldwide. According to the current statistics, over 339 million people who are asthmatic, 65 million who are suffering from COPD, 2.3 million who are lung cancer patients and 10 million are tuberculosis patients. This toll of statistics with chronic respiratory diseases leaves a heavy burden on society and nation annual health expenditure. Hence, a better understanding of the processes governing these cellular pathways will enable us to treat and manage these deadly respiratory diseases effectively. Moreover, it is important to comprehend the synergy and interplay of the cellular signaling pathways in respiratory diseases, which will enable us to explore and develop suitable strategies for targeted drug delivery. This review, in particular, focuses on the major respiratory diseases and further provides an in-depth discussion on the various cell signaling pathways that are involved in the pathophysiology of respiratory diseases. Moreover, the review also analyses the defining concepts about advanced nano-drug delivery systems involving various nanocarriers and propose newer prospects to minimize the current challenges faced by researchers and formulation scientists.

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Development of modified apple polysaccharide capped silver nanoparticles loaded with mesalamine for effective treatment of ulcerative colitis

Cited by 15 publications

References 46 publications

Responsive nanosystems for targeted therapy of ulcerative colitis: Current practices and future perspectives

Responsive nanosystems for targeted therapy of ulcerative colitis: Current practices and future perspectives

A Review on medicinal plants in dentistry

Advancing of Cellular Signaling Pathways in Respiratory Diseases Using Nanocarrier Based Drug Delivery Systems

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