Development of multi-functionalized graphene oxide based nanocarrier for the delivery of poorly water soluble anticancer drugs

Matiyani, Monika; Rana, Anita; Karki, Neha; Garwal, Kamal; Pal, Mintu; Sahoo, Nanda Gopal

doi:10.1016/j.jddst.2023.104412

Cited by 8 publications

(6 citation statements)

References 47 publications

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“…The drug delivery system was created by combining graphene oxide with a hydrophilic polymer and metal oxides, zinc oxide and titanium dioxide. The results showed that the nanocarrier exhibits a pH-sensitive release of loaded drugs, besides demonstrating cytotoxicity towards breast cancer cells [84]. Whereas, Rajaei M. et al [81] synthesized pH-sensitive hydrogel of chitosan/agarose/graphene oxide with glyoxal as the cross-linker.…”

Section: Drug Deliverymentioning

confidence: 99%

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Graphene Production and Biomedical Applications: A Review

Malisz,

Świeczko-Żurek

2023

Crystals

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Graphene is a two-dimensional nanomaterial composed of carbon atoms with sp2 hybrid orbitals. Both graphene and graphene-based composite have gained broad interest among researchers because of their outstanding physiochemical, mechanical, and biological properties. Graphene production techniques are divided into top-down and bottom-up synthesis methods, of which chemical vapor deposition (CVD) is the most popular. The biomedical applications of graphene and its composite include its use in sensors, implantology, and gene and drug delivery. They can be used for tissue engineering, anticancer therapies, and as antimicrobial agents in implant application. The biocompatibility of graphene-based nanomaterials enables their use in the field of biomedicine. This article reviews the properties of graphene, the methods used to produce it, the challenges associated with its use, and the potential applications of this material in biomedicine, regenerative medicine, and drug delivery systems.

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Section: Drug Deliverymentioning

confidence: 99%

“…However, scientists are still working on improving therapeutic methods. Matiyani M. et al [84] developed a multi-functionalized GO-based novel drug nanocarrier for the delivery of the chemotherapeutic. They used quercetin and curcumin, which are potent anticancer drugs.…”

Section: Drug Deliverymentioning

confidence: 99%

Graphene Production and Biomedical Applications: A Review

Malisz,

Świeczko-Żurek

2023

Crystals

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“…The TiO 2 −GO nanocomposites have already been reported for their pHsensitive drug release behavior in breast cancer therapy. 38 In contrast, the ability to sense the neoplastic microenvironment makes TiO 2 −GO an ideal cancer drug delivery candidate. 30…”

Section: Characterization Of Tio 2 −Go Nanocompositesmentioning

confidence: 99%

“…They demonstrated that drug-loaded NCs showed remarkable cytotoxicity toward breast cancer cell lines as compared to free drugs". 38 Considering the merits mentioned above, we selected TiO 2 and GO nanocomposite-based drug delivery of TKIs, namely dasatinib and ponatinib, to Ph+ leukemia cells (Scheme 1). Earlier, the combination therapy of TiO 2 −GO was investigated for treating solid tumors and biosensing; however, to the best of our knowledge, TiO 2 −GO application in Ph+ leukemia is novel.…”

Section: Introductionmentioning

confidence: 99%

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Titania–Graphene Oxide Nanocomposite-Based Philadelphia-Positive Leukemia Therapy

Batool,

Qazi,

Mudassir

et al. 2024

ACS Appl. Bio Mater.

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Philadelphia-positive (Ph+) leukemia is a type of blood cancer also known as acute lymphoblastic leukemia (ALL), affecting 20−30% of adults diagnosed worldwide and having an engraved prognosis as compared to other types of leukemia. The current treatment regimens mainly rely on tyrosine kinase inhibitors (TKIs) and bone marrow transplants. To date, several generations of TKIs have been developed due to associated resistance and frequent relapse, with cardiovascular system anomalies being the most devastating complication. Nanotechnology has the potential to address these limitations by the targeted drug delivery and controlled release of TKIs. This study focused on the titanium dioxide (TiO 2 ) and graphene oxide (GO) nanocomposite employment to load nilotinib and ponatinib TKIs for therapy of Ph+ leukemia cell line (K562) and Ba/F3 cells engineered to express BCR-ABL oncogene. Meanwhile, after treatment, the oncogene expressing fibroblast cells (Rat-1 P185) were evaluated for their colony formation ability under 3D conditions. To validate the nanocomposite formation, the TiO 2 −GO nanocomposites were characterized by scanning electron microscope, DLS, XRD, FTIR, zeta potential, EDX, and element mapping. The TKI-loaded TiO 2 −GO was not inferior to the free drugs after evaluating their effects by a cell viability assay (XTT), apoptosis induction, and colony formation inhibition. The cell signaling pathways of the mammalian target of rapamycin (mTOR), signal transducers and activators of transcription 5 (STAT5), and extracellular signal-regulated kinase (Erk1/2) were also investigated by Western blot. These signaling pathways were significantly downregulated in the TKI-loaded TiO 2 −GO-treated groups. Based on the findings above, we can conclude that TiO 2 −GO exhibited excellent drug delivery potential that can be used for Ph+ leukemia therapy in the future, subject to further investigations.

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Synthesis of Nanocarriers Loaded with Anti-Cancer Drugs by Using Functionalization or Conjugations, Encapsulation Methods

Ravinayagam,

Jermy

2023

Nano Drug Delivery for Cancer Therapy

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Development of multi-functionalized graphene oxide based nanocarrier for the delivery of poorly water soluble anticancer drugs

Cited by 8 publications

References 47 publications

Graphene Production and Biomedical Applications: A Review

Graphene Production and Biomedical Applications: A Review

Titania–Graphene Oxide Nanocomposite-Based Philadelphia-Positive Leukemia Therapy

Synthesis of Nanocarriers Loaded with Anti-Cancer Drugs by Using Functionalization or Conjugations, Encapsulation Methods

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