Development of multifunctional nanocomposites for controlled drug delivery and hyperthermia

Abstract

Magnetic nano/micro-particles based on clinoptilolite-type of natural zeolite (CZ) were fabricated and were expected to act as carriers for controlled drug delivery/release, imaging and local heating in biological systems. Adsorption of rhodamine B, sulfonated aluminum phthalocyanine and hypericin by magnetic CZ nano/micro-particles was investigated, as was the release of hypericin. Using an alternating magnetic field, local temperature increase by 10 °C in animal tissue with injected magnetic CZ particles was demonstrated. In addition, the CZ-based particles have been found to exhibit an anti-amyloidogenic effect on the amyloid aggregation of insulin and lysozyme in a dose- and temperature-dependent manner. Therefore, the mesoporous structure of CZ particles provided a unique platform for preparation of multifunctional magnetic and optical probes suitable for optical imaging, MRI, thermo- and phototherapy and as effective containers for controlled drug delivery. We concluded that magnetic CZ nano/micro-particles could be evaluated for further application in cancer hyperthermia therapy and as anti-amyloidogenic agents.

Zeolites as Ingredients of Medicinal Products

“…Magnetic nano and micro-particles of clinoptilolite (MCZ) were studied as controlled DDS, imaging, and local heating in biological systems [ 132 ]. The magnetic nano/micro-particles were prepared by incorporating iron oxide Fe 3 O 4 into clinoptilolite matrix to create the magnetic properties.…”

Synergistic effects of CuO/TiO2‐chitosan‐farnesol nanocomposites: Synthesis, characterization, antimicrobial, and anticancer activities on melanoma cells SK‐MEL‐3

“…Studies on the biological function of natural nanocomposites with metallic complexes are one important candidate in the new avenues for drug development for various disease ailments [36,37]. In this work, we have formulated, characterized, and tested the antimicrobial and anticancer functions of CuO/TiO 2 -chitosan-farnesol nanocomposites.…”

Targeted Delivery Methods for Anticancer Drugs

“…In general, the conjugates of MNPs with various cytostatics show decreased overall toxicity, and the concentration of cytostatic agents is required to achieve a therapeutic effect [72][73][74][75][76][77]. The ability of MNPs to accumulate in tumors has also been confirmed by MRI [59,74,[78][79][80].…”

“…The morphology and size of both the particles themselves and their pores can be controlled via the choice of a synthetic method [133,134]. MSP-based delivery systems have shown high drug-loading capacity, successfully controlled release, and increased antitumor activity [79,[135][136][137].…”