Development of nano-sized superparamagnetic ferrites having heat generation ability in an AC magnetic field for thermal coagulation therapy

Abstract

Thermal coagulation therapy using powdered magnetic materials in an alternating (AC) magnetic field has been expected as a treatment of cancerous tissues. For nano-sized superparamagnetic particles, the magnetic energy is mainly converted to a heat generation ability by the rotation of the magnetic moment (Néel relaxation) along with the rotation of the particles (Brownian relaxation). Fe 3 O 4 (magnetite) nanoparticles have been mainly investigated as the candidate material for this type of therapy. In this review, an outline of the ferrite materials having heat generation ability in the AC magnetic field is described for the application of the thermal coagulation therapy. In particular, I focused on the preparation of a nano-sized magnetic material using physical bead milling to develop a magnetic material of Y 3 Fe 5 O 12 and its high heat generation ability. The preparation of Y 3 Fe 5 O 12 microspheres with a 2032¯m diameter range using the bead-milled powder was also described for the embolization method of cancer treatment.

Investigations of superparamagnetism in magnesium ferrite nano-sphere synthesized by ultrasonic spray pyrolysis technique for hyperthermia application

“…Where µ 0 is the permeability of free space, χ // is the AC magnetic susceptibility (imaginary part) [53]. This result underscore the possibility that the magnetic field can be tuned to optimize heating for the application of hyperthermia.…”

Application of Ion‐Doped Y3Fe5O12 Nanoparticles for Self‐Controlled Magnetic Hyperthermia

“…Nishimori et al [ 20 ] reported that YIG MNPs with sizes of 20.5–36.8 nm have a maximum thermal efficiency ( coefficient) at an AC magnetic field with a frequency of 370 kHz and an amplitude of 1.77 kA m −1 . For single‐domain MNPs, Aono [ 21 ] demonstrated experimentally that the thermal efficiency of YIG ferrite materials is the highest compared with the most studied Fe 3 O 4 NPs for single‐domain particles. The high value of the effective constant of magnetic anisotropy for single‐domain magnetic YIG NPs compared with bulk samples (≈2 orders of magnitude) [ 22,23 ] is also a prerequisite for maximum thermal efficiency.…”

Свойства синтезированных методом пиролиза ультразвуковой аэрозоли наночастиц MgFe-=SUB=-2-=/SUB=-O-=SUB=-4-=/SUB=- для биомедицинских применений

“…Выбор шпинели MgFe 2 O 4 определился тем, что МНЧ ферритов-шпинелей MFe 2 O 4 (M = Mn, Fe, Co, Ni, Cu или Sr) обладают высокой химической стабильностью, низкой токсичностью и магнитной анизотропией, а также возможностями синтеза частиц заданных размеров и температур Кюри [16][17][18][19]. Все это делает МНЧ шпинели MgFe 2 O 4 ниболее перспективными для использования в разнообразных технологических применениях, а также для биомедицины [20][21][22][23][24][25][26][27][28][29][30][31].…”