Development of new formulation and its evaluation by capillary electrophoresis of tablets containing tramadol hydrochloride and paracetamol

Ciurba, Adriana; Hancu, Gabriel; Cojocea, Livia-Maria; Sipos, Emese; Todoran, Nicoleta

doi:10.3109/10837450.2013.836219

Cited by 9 publications

(5 citation statements)

References 8 publications

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“…Electrophoretic methods such as capillary electrophoresis (CE) can also be used to quantify TXA. These methods are relatively simple and inexpensive to perform, but they may not be as sensitive or selective as chromatographic methods (Wang, 2020;Ciurba et al, 2013). Immunoassay methods such as enzyme-linked immunosorbent assay (ELISA) can be used to quantify TXA in biological samples.…”

Section: Introductionmentioning

confidence: 99%

A Green Raman Spectroscopic Assay Method for The Quantification of Tranexamic Acid in Pharmaceutical Formulations

Singh,

Lokhande,

Kochrekar

2023

IJERR

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Tranexamic acid (TXA) is a widely used antifibrinolytic agent that is used to prevent and treat excessive bleeding. Current analytical methods for TXA are often time-consuming and require the use of toxic solvents. Raman spectroscopy has the ability to measure TXA because it is a fast and non-destructive analytical method. This research established and validated a green Raman spectroscopic test for TXA measurement. There was no need for harmful solvents because the technique relied on a basic aqueous solution of TXA. Results demonstrated that the technique was linear across the 0.7% to 13.0% concentration range. The method was also shown to be accurate, with results comparable to the orthogonal techniques. The green Raman spectroscopic assay method was applied to the quantification of TXA in pharmaceutical formulations. The results obtained were comparable to those obtained using reference methods. To quantify TXA quickly and accurately, one can use the green Raman spectroscopic test. Since no harmful chemicals are needed for the procedure, it is also eco-friendly. Method has the potential to be used in a variety of settings, including pharmaceutical quality control and research laboratories.

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Section: Introductionmentioning

confidence: 99%

A Green Raman Spectroscopic Assay Method for The Quantification of Tranexamic Acid in Pharmaceutical Formulations

Singh,

Lokhande,

Kochrekar

2023

IJERR

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“…Currently, in the manufacturing of paracetamol tablets and the quantitation of the final product, HPLC is usually used to measure the API content, presenting disadvantages such as the consumption of the chromatographic column and solvent, complicated preprocessing, and deviations in results obtained by different operators. In addition, electroanalytical [ 21 ], capillary electrophoretic [ 22 , 23 ], and spectrophotometric methods [ 24 ] have also been applied to the determination of paracetamol content [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Application of Transmission Raman Spectroscopy in Combination with Partial Least-Squares (PLS) for the Fast Quantification of Paracetamol

et al. 2022

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In recent years, transmission Raman spectroscopy (TRS) has emerged as a potent new tool for rapid, nondestructive quantitation in pharmaceutical manufacturing. In order to expand the applicability of TRS and enhance its use in product quality monitoring during drug production, we aimed, in the present study, to apply partial least-squares (PLS) approaches to build a model consisting of 150 handmade tablets and covering 15 levels through the use of a multifactor orthogonal design of experiment (DOE), which was used to predict concentrations of validation tablets made by hand. The difference between results according to HPLC and TRS were negligible. The model was used to predict the active pharmaceutical ingredient (API) content in four random commercial paracetamol tablets, and corrected with the spectra of the commercial tablets to obtain four corresponding models. The results show that the content relative error in the model’s predictions after correction with commercially available tablets was significantly lower than that before correction. The corrected model was used to make predictions for 20 tablets from the brand Panadol. Compared with the HPLC results, the prediction relative error was basically less than 4.00%, and the relative standard deviation (RSD) of the content was 0.86%.

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“…Up till now, a number of studies have been performed including high performance liquid chromatography with UV and electrospray ionization mass spectrophotometric detections, gas chromatography with mass spectrophotometric detection , capillary electrophoresis , UV spectrophotometry , and voltammetry for the determination of ACP and TRA in their binary mixtures.…”

Section: Introductionmentioning

confidence: 99%

“…Up till now, a number of studies have been performed including high performance liquid chromatography with UV [7] and electrospray ionization mass spectrophotometric [8] detections, gas chromatography with mass spectrophotometric detection [7], capillary electrophoresis [9], UV spectrophotometry [10,11], and voltammetry [ 18] for the determination of ACP and TRA in their binary mixtures. Among the instrumental techniques, voltammetry provides not only inexpensive, rapid and simple benefits for chemical analysis, but also presents useful information about the oxidation/reduction (redox) mechanism of the corresponding electroactive species.…”

Section: Introductionmentioning

confidence: 99%

A Simple Approach to Simultaneous Electroanalytical Quantification of Acetaminophen and Tramadol Using a Boron‐doped Diamond Electrode in the Existence of Sodium Dodecyl Sulfate

et al. 2019

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The present work describes the individual, selective and simultaneous quantification of acetaminophen (ACP) and tramadol hydrochloride (TRA) using a modification‐free boron‐doped diamond (BDD) electrode. Cyclic voltammetric measurements revealed that the profile of the binary mixtures of ACP and TRA were manifested by two irreversible oxidation peaks at about +1.04 V (for ACP) and +1.61 V (for TRA) in Britton‐Robinson (BR) buffer pH 3.0. TRA oxidation peak was significantly improved in the presence of anionic surfactant, sodium dodecyl sulfate (SDS), while ACP signal did not change. By employing square‐wave stripping mode in BR buffer pH 3.0 containing 8×10−4 mol L−1 SDS after 30 s accumulation under open‐circuit voltage, the BDD electrode could be used for quantification of ACP and TRA simultaneously in the ranges 1.0–70 μg mL−1 (6.6×10−6–4.6×10−4 mol L−1) and 1.0–70 μg mL−1 (3.3×10−6–2.3×10−4 mol L−1), with detection limits of 0.11 μg mL−1 (7.3×10−7 mol L−1) and 0.13 μg mL−1 (4.3×10−7 mol L−1), respectively. The practical applicability of the proposed approach was tested for the individual and simultaneous quantification of ACP and/or TRA in the pharmaceutical dosage forms.

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Development of new formulation and its evaluation by capillary electrophoresis of tablets containing tramadol hydrochloride and paracetamol

Cited by 9 publications

References 8 publications

A Green Raman Spectroscopic Assay Method for The Quantification of Tranexamic Acid in Pharmaceutical Formulations

A Green Raman Spectroscopic Assay Method for The Quantification of Tranexamic Acid in Pharmaceutical Formulations

Application of Transmission Raman Spectroscopy in Combination with Partial Least-Squares (PLS) for the Fast Quantification of Paracetamol

A Simple Approach to Simultaneous Electroanalytical Quantification of Acetaminophen and Tramadol Using a Boron‐doped Diamond Electrode in the Existence of Sodium Dodecyl Sulfate

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