Development of niosomes for encapsulating captopril-quercetin prodrug to combat hypertension

Sayyad, Nisar; Maji, Ruma; Omolo, Calvin A.; Ganai, Ab Majeed; Ibrahim, Usri H.; Pathan, Tabasum Khan; Devnarain, Nikita; Karpoormath, Rajshekhar; Dhawan, Sanjeev; Obakachi, Vincent A.; Merugu, Srinivas Reddy; Kayamba, Francis; Mahlalela, Mavela Cleopus; Govender, Thirumala; Tzakos, Andreas G.; Singh, Parvesh

doi:10.1016/j.ijpharm.2021.121191

Cited by 12 publications

(10 citation statements)

References 53 publications

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“…Globally, HTN continues to be a major risk factor for cardiovascular disease and mortality ( Reboldi et al, 2022 ). HTN is often called the silent killer because it is asymptomatic in many cases and symptoms are difficult to detect without special apparatus, causing around 9.4 million deaths worldwide ( Kalehoff & Oparil, 2020 ; Sayyad et al, 2021 ).…”

Section: Review Of Literaturementioning

confidence: 99%

“…Furthermore, effective management of stroke depends mainly on the public's awareness of its warning signs, which could help in earlier detection and better response rates ( Kalehoff & Oparil, 2020 ; Sayyad et al, 2021 ). As HTN is considered a main modifiable risk factor for stroke, there is still a lack of studies that examine hypertensive patients’ awareness of stroke.…”

Section: Review Of Literaturementioning

confidence: 99%

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Knowledge, Attitudes, and Practices of Hypertensive Patients Towards Stroke Prevention Among Rural Population in Saudi Arabia: A Cross-Sectional Study

et al. 2023

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Introduction Stroke is a significant health problem and is considered one of the leading causes of mortality and permanent disability worldwide. Hypertension is a primary risk factor for stroke. Thus, hypertensive patients’ knowledge, attitudes, and practices (KAP) are essential in preventing stroke. Objective To examine hypertensive patients’ KAP towards stroke prevention among rural population in Saudi Arabia. Methods The study utilized a cross-sectional design. The data were collected using a convenience sampling technique from hypertensive patients in the northwestern rural areas of Riyadh Province. A self-administered questionnaire was adapted from the Stroke Recognition Questionnaire (SRQ) and utilized to assess KAP towards stroke prevention among rural hypertensive patients. The STrengthening of the Reporting of OBservational studies in Epidemiology (STROBE) checklist was used to report the study. Results A total of 196 hypertensive patients participated in the study. The total mean scores categorization into three quartiles showed that most respondents had poor levels of KAP towards stroke prevention. Weak positive correlations were found between KAP of patients. There were statistically significant differences between respondents’ attitudes and practices with their age, education, marital status, and occupational status. Discussion This study denoted poor levels of KAP towards stroke prevention among hypertensive patients living in rural areas. This study showed the importance of further considering rural population by which improving their health and quality of life. Extending health educational programs and behavior-changing strategies to rural areas is essential to increase hypertensive patients and general public awareness about their stroke prevention and other health-related concerns.

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Section: Review Of Literaturementioning

confidence: 99%

Section: Review Of Literaturementioning

confidence: 99%

Knowledge, Attitudes, and Practices of Hypertensive Patients Towards Stroke Prevention Among Rural Population in Saudi Arabia: A Cross-Sectional Study

et al. 2023

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“…However, at room temperature (25 ± 2 °C), the niosomal formula was found to aggregate, indicating that the fluidity of the bilayer membrane increased at higher temperatures (Kulkarni et al 2021 ). Because the lipophilic part rigidity in the niosomes rises at lower temperatures, the sample held at 4 °C was more stable than that kept at 25 °C (Sayyad et al 2021 ). Another essential stability parameter is the niosomes’ capability to retain the drug in its encapsulated form during the storage period.…”

Section: Resultsmentioning

confidence: 99%

Niosomal formulation of mefenamic acid for enhanced cancer targeting; preparation, characterization and biodistribution study using radiolabeling technique

Shewaiter,

Selim,

Rashed

et al. 2023

J Cancer Res Clin Oncol

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Background This work aimed to prepare niosomal formulations of an anticancer agent [mefenamic acid (MEF)] to enhance its cancer targeting. 131I was utilized as a radiolabeling isotope to study the radio-kinetics of MEF niosomes. Methods niosomal formulations were prepared by the ether injection method and assessed for entrapment efficiency (EE%), zeta potential (ZP), polydispersity index (PDI) and particle size (PS). MEF was labeled with 131I by direct electrophilic substitution reaction through optimization of radiolabeling-related parameters. In the radio-kinetic study, the optimal 131I-MEF niosomal formula was administered intravenously (I.V.) to solid tumor-bearing mice and compared to I.V. 131I-MEF solution as a control. Results the average PS and ZP values of the optimal formulation were 247.23 ± 2.32 nm and − 28.3 ± 1.21, respectively. The highest 131I-MEF labeling yield was 98.7 ± 0.8%. The biodistribution study revealed that the highest tumor uptake of 131I-MEF niosomal formula and 131I-MEF solution at 60 min post-injection were 2.73 and 1.94% ID/g, respectively. Conclusion MEF-loaded niosomes could be a hopeful candidate in cancer treatment due to their potent tumor uptake. Such high targeting was attributed to passive targeting of the nanosized niosomes and confirmed by radiokinetic evaluation.

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“…To this aim, Q, a nonenzymatic antioxidant, has been used for the first time for a OGB to inactivate the possible free radicals during oxygenation. This nonenzymatic antioxidant is quite stable and multifunctional; therefore, Q not only can scavenge the free radicals like ROS but also can bring other features for OGBs like antibacterial properties (Amer et al, 2021; Sayyad et al, 2021). To investigate the effect of Q on free radicals, it is necessary to evaluate the antioxidant properties of specimens.…”

Section: Resultsmentioning

confidence: 99%

A hydrogel–fiber–hydrogel composite scaffold based on silk fibroin with the dual‐delivery of oxygen and quercetin

Aleemardani

Solouk

Akbari

et al. 2022

Biotech & Bioengineering

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Supplying sufficient oxygen within the scaffolds is one of the essential hindrances in tissue engineering that can be resolved by oxygen‐generating biomaterials (OGBs). Two main issues related to OGBs are controlling oxygenation and reactive oxygen species (ROS). To address these concerns, we developed a composite scaffold entailing three layers (hydrogel‐electrospun fibers‐hydrogel) with antioxidant and antibacterial properties. The fibers, the middle layer, reinforced the composite structure, enhancing the mechanical strength from 4.27 ± 0.15 to 8.27 ± 0.25 kPa; also, this layer is made of calcium peroxide and silk fibroin (SF) through electrospinning, which enables oxygen delivery. The first and third layers are physical SF hydrogels to control oxygen release, containing quercetin (Q), a nonenzymatic antioxidant. This composite scaffold resulted in almost more than 40 mmHg of oxygen release for at least 13 days, and compared with similar studies is in a high range. Here, Q was used for the first time for an OGB to scavenge the possible ROS. Q delivery not only led to antioxidant activity but also stabilized oxygen release and enhanced cell viability. Based on the given results, this composite scaffold can be introduced as a safe and controllable oxygen supplier, which is promising for tissue engineering applications, particularly for bone.

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Development of niosomes for encapsulating captopril-quercetin prodrug to combat hypertension

Cited by 12 publications

References 53 publications

Knowledge, Attitudes, and Practices of Hypertensive Patients Towards Stroke Prevention Among Rural Population in Saudi Arabia: A Cross-Sectional Study

Knowledge, Attitudes, and Practices of Hypertensive Patients Towards Stroke Prevention Among Rural Population in Saudi Arabia: A Cross-Sectional Study

Niosomal formulation of mefenamic acid for enhanced cancer targeting; preparation, characterization and biodistribution study using radiolabeling technique

A hydrogel–fiber–hydrogel composite scaffold based on silk fibroin with the dual‐delivery of oxygen and quercetin

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