Development of Novel Polymeric Materials for Gene Therapy and pH-Sensitive Drug Delivery: Modeling, Synthesis, Characterization, and Analysis

Anderson, Brian C.

doi:10.2172/804533

Cited by 1 publication

(3 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is reflected by the high value for R 2 observed when fitting data to the Korsmeyer-Peppas model. Swelling controlled the release of 3TC and AZT from these devices due to water penetrating the bulk of this device manufactured with water-soluble polymers, which also dissolve over time suggesting that erosion also has an impact on drug release from these systems [86]. However, in this case, the polymers are likely to detach from the surfaces of the solid unit of the polymer and not monomeric units on dissolution [86].…”

Section: Best Fit Modelmentioning

confidence: 99%

“…PF-127 gel systems have been described as dissolution controlled technologies in which a combination of erosion and diffusion controlled release occur [86,87]. This is reflected by the high value for R 2 observed when fitting data to the Korsmeyer-Peppas model.…”

Section: Best Fit Modelmentioning

confidence: 99%

“…Swelling controlled the release of 3TC and AZT from these devices due to water penetrating the bulk of this device manufactured with water-soluble polymers, which also dissolve over time suggesting that erosion also has an impact on drug release from these systems [86]. However, in this case, the polymers are likely to detach from the surfaces of the solid unit of the polymer and not monomeric units on dissolution [86]. The dissolution of the Pluronic ® gel system occurs due to interaction of polymeric micelles with molecules of water resulting in dissociation of the micellar aggregates from the surfaces of the matrix into the dissolution medium [68].…”

Section: Best Fit Modelmentioning

confidence: 99%

See 2 more Smart Citations

Nano Co-Crystal Embedded Stimuli-Responsive Hydrogels: A Potential Approach to Treat HIV/AIDS

et al. 2021

View full text Add to dashboard Cite

Currently, the human immunodeficiency virus (HIV) that causes acquired immunodeficiency syndrome (AIDS) can only be treated successfully, using combination antiretroviral (ARV) therapy. Lamivudine (3TC) and zidovudine (AZT), two compounds used for the treatment of HIV and prevention of disease progression to AIDS are used in such combinations. Successful therapy with 3TC and AZT requires frequent dosing that may lead to reduced adherence, resistance and consequently treatment failure. Improved toxicity profiles of 3TC and AZT were observed when combined as a nano co-crystal (NCC). The use of stimuli-responsive delivery systems provides an opportunity to overcome the challenge of frequent dosing, by controlling and/or sustaining delivery of drugs. Preliminary studies undertaken to identify a suitable composition for a stimulus-responsive in situ forming hydrogel carrier for 3TC-AZT NCC were conducted, and the gelation and erosion time were determined. A 25% w/w Pluronic® F-127 thermoresponsive hydrogel was identified as a suitable carrier as it exhibited a gelation time of 5 min and an erosion time of 7 days. NCC-loaded hydrogels were evaluated using in vitro dissolution and cytotoxicity assays. In vitro dissolution undertaken using membrane-less diffusion over 168 h revealed that 3TC and AZT release from NCC-loaded hydrogels was complete and followed zero-order kinetic processes, whereas those loaded with the micro co-crystal and physical mixture were incomplete and best described using the Korsmeyer–Peppas kinetic model. The release of AZT and 3TC from the physical mixture and MCC-loaded gel exhibited a value for n of 0.595 for AZT release from the physical mixture and 0.540 for the MCC technology, whereas the release exponent for 3TC was 0.513 for the physical mixture and 0.557 for the MCC technology indicating that diffusion and erosion controlled 3TC and AZT release. In vitro cytotoxicity assay data revealed that the addition of NCC to the thermoresponsive hydrogel resulted in an improved cell viability of 88.0% ± 5.0% when compared to the cell viability of the NCC of 76.9% ± 5.0%. The results suggest that the use of a thermoresponsive nanosuspension may have the potential to be delivered as an intramuscular injection that can subsequently increase bioavailability and permit dose reduction and/or permit use of a longer dosing frequency.

show abstract

Section: Best Fit Modelmentioning

confidence: 99%

Section: Best Fit Modelmentioning

confidence: 99%