Development of NREM Sleep Instability-Continuity (Cyclic Alternating Pattern) in Healthy Term Infants Aged 1 to 4 months

Miano, Silvia; PiaVilla, Maria; Blanco, Dora; Zamora, Elena; Rodríguez, Rosa M.; Ferri, Raffaele; Bruni, Oliviero; Peraita-Adrados, Rosa

doi:10.5665/sleep/32.1.83

Cited by 2 publications

(2 citation statements)

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“…The mature stage 2 of NREM sleep with EEG spindles emerges between 6 and 9 weeks, and slow delta waves mixed with theta frequencies appear at approximately 12 weeks of age [ 11 , 50 , 51 ]. K-complex begins to have a drastic increase in the percentage of stage 2 of NREM sleep over TST by the end of 6 months.…”

Section: Rem Sleep In Early Development Of Humansmentioning

confidence: 99%

“…The predictable appearance in the evening (around 20:00 h) of a long period of sleep, highly organized into REM-NREM sleep stages, occurs first in infants of 3 months of age [ 46 ]. Meanwhile, the appearance of NREM sleep at sleep onset and cyclic alternating patterns are sometimes observed [ 11 , 51 ]. Furthermore, NREM sleep is largely increased at night [ 50 , 73 , 74 , 75 ].…”

Section: Rem Sleep In Early Development Of Humansmentioning

confidence: 99%

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Rapid Eye Movement Sleep during Early Life: A Comprehensive Narrative Review

Chen

Gao

Chen

et al. 2022

IJERPH

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The ontogenetic sleep hypothesis suggested that rapid eye movement (REM) sleep is ontogenetically primitive. Namely, REM sleep plays an imperative role in the maturation of the central nervous system. In coincidence with a rapidly developing brain during the early period of life, a remarkably large amount of REM sleep has been identified in numerous behavioral and polysomnographic studies across species. The abundant REM sleep appears to serve to optimize a cerebral state suitable for homeostasis and inherent neuronal activities favorable to brain maturation, ranging from neuronal differentiation, migration, and myelination to synaptic formation and elimination. Progressively more studies in Mammalia have provided the underlying mechanisms involved in some REM sleep-related disorders (e.g., narcolepsy, autism, attention deficit hyperactivity disorder (ADHD)). We summarize the remarkable alterations of polysomnographic, behavioral, and physiological characteristics in humans and Mammalia. Through a comprehensive review, we offer a hybrid of animal and human findings, demonstrating that early-life REM sleep disturbances constitute a common feature of many neurodevelopmental disorders. Our review may assist and promote investigations of the underlying mechanisms, functions, and neurodevelopmental diseases involved in REM sleep during early life.

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Section: Rem Sleep In Early Development Of Humansmentioning

confidence: 99%

Section: Rem Sleep In Early Development Of Humansmentioning

confidence: 99%

Rapid Eye Movement Sleep during Early Life: A Comprehensive Narrative Review

Chen

Gao

Chen

et al. 2022

IJERPH

View full text Add to dashboard Cite

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Sleep and brain evolution across the human lifespan: A mutual embrace

Mutti

Misirocchi²,

Zilioli³

et al. 2022

Front. Netw. Physiol.

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Sleep can be considered a window to ascertain brain wellness: it dynamically changes with brain maturation and can even indicate the occurrence of concealed pathological processes. Starting from prenatal life, brain and sleep undergo an impressive developmental journey that accompanies human life throughout all its steps. A complex mutual influence rules this fascinating course and cannot be ignored while analysing its evolution. Basic knowledge on the significance and evolution of brain and sleep ontogenesis can improve the clinical understanding of patient’s wellbeing in a more holistic perspective. In this review we summarized the main notions on the intermingled relationship between sleep and brain evolutionary processes across human lifespan, with a focus on sleep microstructure dynamics.

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Development of NREM Sleep Instability-Continuity (Cyclic Alternating Pattern) in Healthy Term Infants Aged 1 to 4 months

Cited by 2 publications

References 24 publications

Rapid Eye Movement Sleep during Early Life: A Comprehensive Narrative Review

Rapid Eye Movement Sleep during Early Life: A Comprehensive Narrative Review

Sleep and brain evolution across the human lifespan: A mutual embrace

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