Development of On and Off retinal pathways and retinogeniculate projections

Chalupa, Leo M.; Günhan, Emine

doi:10.1016/j.preteyeres.2003.10.001

Cited by 72 publications

(71 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Early in development, ganglion cell dendrites appear to ramify through the entire depth of the IPL in mammals (Bodnarenko et al, 1995;Maslim and Stone, 1988). Extensive reorganization, including the retraction of inappropriately placed dendrites, is suggested to lead to their mature stratification pattern (Chalupa and Gunhan, 2004;Maslim and Stone, 1988). In the light of the findings here, it will be of interest to determine whether non-mammalian ganglion cells undergo extensive dendritic remodeling as well.…”

Section: Discussionmentioning

confidence: 75%

Targeting of amacrine cell neurites to appropriate synaptic laminae in the developing zebrafish retina

et al. 2005

View full text Add to dashboard Cite

Cellular mechanisms underlying the precision by which neurons target their synaptic partners have largely been determined based on the study of projection neurons. By contrast, little is known about how interneurons establish their local connections in vivo. Here, we investigated how developing amacrine interneurons selectively innervate the appropriate region of the synaptic neuropil in the inner retina, the inner plexiform layer (IPL). Increases (ON) and decreases (OFF) in light intensity are processed by circuits that are structurally confined to separate ON and OFF synaptic sublaminae within the IPL. Using transgenic zebrafish in which the majority of amacrine cells express fluorescent protein, we determined that the earliest amacrine-derived neuritic plexus formed between two cell populations whose somata, at maturity, resided on opposite sides of this plexus. When we followed the behavior of individual amacrine cells over time, we discovered that they exhibited distinct patterns of structural dynamics at different stages of development. During cellular migration, amacrine cells exhibited an exuberant outgrowth of neurites that was undirected. Upon reaching the forming IPL, neurites extending towards the ganglion cell layer were relatively more stable. Importantly, when an arbor first formed, it preferentially ramified in either the inner or outer IPL corresponding to the future ON and OFF sublaminae, and maintained this stratification pattern. The specificity by which ON and OFF amacrine interneurons innervate their respective sublaminae in the IPL contrasts with that observed for projection neurons in the retina and elsewhere in the central nervous system.

show abstract

Section: Discussionmentioning

confidence: 75%

Targeting of amacrine cell neurites to appropriate synaptic laminae in the developing zebrafish retina

et al. 2005

View full text Add to dashboard Cite

show abstract

“…These cells are exclusively D2 RGCs in this study. It is worth noting that the definition of "bistratified" RGCs used in this study, which includes only RGCs with whole dendritic trees clearly separated into two layers of plexi, is different from that used in previous reports by us and by others (Bodnarenko and Chalupa, 1993;Bodnarenko et al, 1995Bodnarenko et al, , 1999Wang et al, 2001;Tian and Copenhagen, 2003;Deplano et al, 2004;Chalupa and The Journal of Comparative Neurology. DOI 10.1002/cne Gü nhan, 2004), in which all RGCs ramified in both sublaminae a and b of the IPL were considered as "bistratified" RGCs regardless of whether their dendrites stratified into a single layer or multiple layers.…”

Section: The Developmental Dendritic Redistribution Of Rgcs Altered Tmentioning

confidence: 94%

“…RGCs with dendrites exclusively ramified in either sublamina a or b were classified as OFF or ON cells, respectively. RGCs that arborized their dendrites in only one layer but ramified in both sublaminae a and b might receive synaptic inputs from both ON and OFF BCs (Wang et al, 2001;Chalupa and Gü nhan, 2004) and, therefore, were classified as monostratified ON-OFF RGCs. The representative images and the dendritic pixel distribution curves of an ON (left), OFF (middle), and monostratified ON-OFF RGCs (right) are show in Figure 7A.…”

Section: The Developmental Dendritic Redistribution Of Rgcs Altered Tmentioning

confidence: 99%

Retinal ganglion cell dendrites undergo a visual activity‐dependent redistribution after eye opening

Tian

2007

J of Comparative Neurology

View full text Add to dashboard Cite

Recent studies showed that light stimulation is required for the maturational segregation of retinal ganglion cell (RGC) synaptic connectivity with ON and OFF bipolar cells in mammalian retina. However, it is not clear to what extent light stimulation regulates the maturation of RGC dendritic ramification and synaptic connections. The present work quantitatively analyzed the dendritic ramification patterns of different morphological subtypes of RGCs of developing mouse retinas and demonstrated that RGCs in all four major morphological subtypes underwent profound dendritic redistributions from the center to specific stratum of the IPL after eye opening. Light deprivation preferentially blocked the developmental RGC dendritic redistribution from the center to sublamina a of the IPL. Interestingly, this developmental redistribution of RGC dendrites could not be explained by a simple developmental elimination of "excess" dendrites and, therefore, suggests a possible mechanism that requires both selective dendritic growth and elimination guided by visual activity.

show abstract

“…The visual system has long been a favorite model for developmental studies and the mechanisms that regulate dendritic and axonal development of retinal ganglion cells (RGCs) are beginning to emerge Permanent Changes in Retinal Ganglion Cells Dev Neurosci 2004;26:396-405 397 [Wingate, 1996;Wong and Ghosh, 2002;Chalupa and Huberman, 2004]. Early in development the dendrites of RGCs ramify throughout the inner plexiform layer (IPL), and the restriction of these processes into ON and OFF sublaminae occurs mainly during the period when bipolar cells form synapses with RGCs Stone, 1986, 1988], implying a causal link between these two developmental events [for review see Chalupa and Gunhan, 2004].…”

Section: Introductionmentioning

confidence: 99%

Long-Term Treatment of the Developing Retina with the Metabotropic Glutamate Agonist APB Induces Long-Term Changes in the Stratification of Retinal Ganglion Cell Dendrites

Deplano

Gargini²,

Maccarone³

et al. 2004

Dev Neurosci

Self Cite

View full text Add to dashboard Cite

The gradual restriction of initially multistratified retinal ganglion cell (RGC) dendrites into ON and OFF sublaminae of the inner plexiform layer (IPL) can be effectively blocked by treating the developing retina with 2-amino-4-phosphonobutyrate (APB), the metabotropic glutamate agonist, or by light deprivation. Previous studies have focused on the short-term consequences of such manipulations, so the long-term effects of arresting dendritic stratification on the structural development of RGCs are as yet unknown. In the present study, we have addressed this issue by performing a morphological analysis of α RGCs labeled by retrograde transport of horseradish peroxidase injected into the dorsal lateral geniculate nucleus of adult cats that received monocular injections of APB from postnatal (P) day 2 until P30. A large proportion of the α cells in the APB-treated eye (44%) were found to have multistratified dendrites that terminated in both the ON and OFF sublaminae of the IPL. The dendritic arborization pattern in the sublaminae of the IPL of these cells was asymmetric, showing a variety of forms. Immunolabeling of retinal cross-sections showed that mGLUR6 receptors appeared normal in density and location, while qualitative observation suggested an increase in the axonal arborization of rod bipolar cells. These findings indicate that long-term treatment of the neonatal retina with APB induces a long- lasting structural reorganization in retinal circuitry that most likely accounts for some of the previously described changes in the functional properties of RGCs.

show abstract

Development of On and Off retinal pathways and retinogeniculate projections

Cited by 72 publications

References 74 publications

Targeting of amacrine cell neurites to appropriate synaptic laminae in the developing zebrafish retina

Targeting of amacrine cell neurites to appropriate synaptic laminae in the developing zebrafish retina

Retinal ganglion cell dendrites undergo a visual activity‐dependent redistribution after eye opening

Long-Term Treatment of the Developing Retina with the Metabotropic Glutamate Agonist APB Induces Long-Term Changes in the Stratification of Retinal Ganglion Cell Dendrites

Contact Info

Product

Resources

About