Development of organic photosensitizers for antimicrobial photodynamic therapy

Zhou, Wenxia; Jiang, Xiqun; Wang, Chao

doi:10.1039/d3bm00730h

Cited by 28 publications

(7 citation statements)

References 123 publications

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“…For this reason, a wide range of photosensitizers are available and can be tested in clinical trials. These include natural chemicals such as curcumin, hypericin, and chlorophyllin, as well as classes of pigments such as phenothiazinium, porphyrins, chlorites, and phthalocyanines [14]. Excellent articles [15,16] provide a summary of data on light sources that can be used in aPDI.…”

Section: Mechanism Of Apdi and The Possibility Of Developing Tolerancementioning

confidence: 99%

On the Possibility of Using 5-Aminolevulinic Acid in the Light-Induced Destruction of Microorganisms

Zdubek,

Maliszewska

2024

IJMS

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Antimicrobial photodynamic inactivation (aPDI) is a method that specifically kills target cells by combining a photosensitizer and irradiation with light at the appropriate wavelength. The natural amino acid, 5-aminolevulinic acid (5-ALA), is the precursor of endogenous porphyrins in the heme biosynthesis pathway. This review summarizes the recent progress in understanding the biosynthetic pathways and regulatory mechanisms of 5-ALA synthesis in biological hosts. The effectiveness of 5-ALA-aPDI in destroying various groups of pathogens (viruses, fungi, yeasts, parasites) was presented, but greater attention was focused on the antibacterial activity of this technique. Finally, the clinical applications of 5-ALA in therapies using 5-ALA and visible light (treatment of ulcers and disinfection of dental canals) were described.

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Section: Mechanism Of Apdi and The Possibility Of Developing Tolerancementioning

confidence: 99%

On the Possibility of Using 5-Aminolevulinic Acid in the Light-Induced Destruction of Microorganisms

Zdubek,

Maliszewska

2024

IJMS

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“…The optimal PS should target both Gram-positive and Gram-negative species, accounting for their differential treatment responses. Several very recent studies have described the latest advancements in the field over the past years, emphasizing new PS systems relevant for antibacterial PDT's methodologies [80,[130][131][132], which have recently reviewed by Sébastien Clément & Jean-Yves Winum [123].…”

Section: Risk Of Antibiotic Inactivationmentioning

confidence: 99%

Reactive Oxygen Species (ROS)-Mediated Antibacterial Oxidative Therapies: Available Methods to Generate ROS and a Novel Option Proposal

Alfei,

Schito,

Schito

et al. 2024

Preprint

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The increasing emergence of multidrug resistant (MDR) pathogens causes difficult-to-treat infections, with long-term hospitalizations and high incidence of death, thus representing a global public health problem. To manage MDR bacteria bugs, new antimicrobial strategies are necessary, and their introduction in practice is a daily challenge for scientists in the field. An extensively studied approach to treat MDR infections consists in inducing high levels of reactive oxygen species (ROS) by several methods. Although further clinical investigations are mandatory on the possible toxic effects of ROS to mammalian cells, clinical evaluations are extremely promising, and their topical use to treat infected wounds and ulcers, also in presence of biofilm, is already clinically approved. Biochar (BC) is a carbonaceous material obtained by pyrolysis of different vegetable and animal biomass feedstocks, at 200−1000 °C in limited presence of O2. Recently, it has been demonstrated that BC capability of removing organic and inorganic xenobiotics is mainly due to the presence of persistent free radicals (PFRs), which can activate oxygen, H2O2 or persulfate in the presence or not of transition metals by electron transfer thus generating ROS, which in turn degrade pollutants by advanced oxidation processes (AOPs). In this context, the antibacterial effects of BC containing PFRs have been demonstrated by some authors against Escherichia coli and Staphylococcus aureus, thus giving birth to our idea of the possible use of BC-derived PFRs as a novel method capable of inducing ROS generation for antimicrobial oxidative therapy. Here, the general aspects concerning ROS physiological and pathological production and regulation, and the mechanism by which they could exert antimicrobial effects have been reviewed. The methods currently adopted to induce ROS production for antimicrobial oxidative therapy have been discussed. Finally, for the first time, BC-related PFRs have been proposed as a new source of ROS for antimicrobial therapy via AOPs.

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“…7 However, photodynamic therapy (PDT) has emerged as a promising alternative to antibacterial drugs, garnering significant attention. 8,9 PDT offers several advantages, including its noninvasive nature, excellent selectivity, low toxicity, and limited side effects. 10−12 PDT involves the use of photosensitizers (PSs) and specific light sources to interact with intracellular oxygen, generating reactive oxygen species (ROS).…”

Section: Introductionmentioning

confidence: 99%

“…The second approach utilizes combination drug therapies in clinical settings . However, photodynamic therapy (PDT) has emerged as a promising alternative to antibacterial drugs, garnering significant attention. , PDT offers several advantages, including its noninvasive nature, excellent selectivity, low toxicity, and limited side effects. − …”

Section: Introductionmentioning

confidence: 99%

Amphiphilic AIE Fluorescent Probe: A Dual-Functionality Strategy for Efficient Antibacterial Therapy Fluorescence Bioimaging against Staphylococcus aureus

Fang,

Wang,

Yao

et al. 2024

ACS Appl. Bio Mater.

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Drug-resistant bacteria present a grave threat to human health. Fluorescence imaging-guided photodynamic antibacterial therapy holds enormous potential as an innovative treatment in antibacterial therapy. However, the development of a fluorescent material with good water solubility, large Stokes shift, bacterial identification, and high photodynamic antibacterial efficiency remains challenging. In this study, we successfully synthesized an amphiphilic aggregation-induced emission (AIE) fluorescent probe referred to as NPTPA-QM. This probe possesses the ability to perform live-bacteria fluorescence imaging while also exhibiting antibacterial activity, specifically against Staphylococcus aureus (S. aureus). We demonstrate that NPTPA-QM can eliminate S. aureus at a very low concentration (2 μmol L −1 ). Moreover, it can effectively promote skin wound healing. Meanwhile, this NPTPA-QM exhibits an excellent imaging ability by simple mixing with S. aureus. In summary, this research presents a straightforward and highly effective method for creating "amphiphilic" AIE fluorescent probes with antibacterial properties. Additionally, it offers a rapid approach for imaging bacteria utilizing red emission.

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Development of organic photosensitizers for antimicrobial photodynamic therapy

Abstract: Bacterial infection poses a significant threat to human health, and the emergence of antibiotic-resistant strains has exacerbated the situation. Antimicrobial photodynamic therapy (aPDT) has emerged as a promising antibiotic-free treatment...

Cited by 28 publications

References 123 publications

On the Possibility of Using 5-Aminolevulinic Acid in the Light-Induced Destruction of Microorganisms

On the Possibility of Using 5-Aminolevulinic Acid in the Light-Induced Destruction of Microorganisms

Reactive Oxygen Species (ROS)-Mediated Antibacterial Oxidative Therapies: Available Methods to Generate ROS and a Novel Option Proposal

Amphiphilic AIE Fluorescent Probe: A Dual-Functionality Strategy for Efficient Antibacterial Therapy Fluorescence Bioimaging against Staphylococcus aureus

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