Development of pH-responsive core–shell nanocarriers for delivery of therapeutic and diagnostic agents

Xu, Shangjie; Luo, Ying; Graeser, Ralph; Warnecke, André; Kratz, Felix; Hauff, Peter; Licha, Kai; Haag, Rainer

doi:10.1016/j.bmcl.2008.01.043

Cited by 77 publications

(40 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Analogous core-shell structures using HPG/ HPAMAM core, PEG shell and pH-labile linkers were also reported. [125][126][127] We have prepared a pH-responsive hyperbranched multiarm copolymer of HPG-star -PDMAEMA (Figure 16 a). [ 128 ] As shown in Figure 16 b, this copolymer can form multimolecular micelles in both acidic and alkaline solutions.…”

Section: Environment Responsive Micellesmentioning

confidence: 99%

Self‐Assembly of Hyperbranched Polymers and Its Biomedical Applications

et al. 2010

View full text Add to dashboard Cite

Hyperbranched polymers (HBPs) are highly branched macromolecules with a three-dimensional dendritic architecture. Due to their unique topological structure and interesting physical/chemical properties, HBPs have attracted wide attention from both academia and industry. In this paper, the recent developments in HBP self-assembly and their biomedical applications have been comprehensively reviewed. Many delicate supramolecular structures from zero-dimension (0D) to three-dimension (3D), such as micelles, fibers, tubes, vesicles, membranes, large compound vesicles and physical gels, have been prepared through the solution or interfacial self-assembly of amphiphilic HBPs. In addition, these supramolecular structures have shown promising applications in the biomedical areas including drug delivery, protein purification/detection/delivery, gene transfection, antibacterial/antifouling materials and cytomimetic chemistry. Such developments promote the interdiscipline researches among surpramolecular chemistry, biomedical chemistry, nano-technology and functional materials.

show abstract

Section: Environment Responsive Micellesmentioning

confidence: 99%

Self‐Assembly of Hyperbranched Polymers and Its Biomedical Applications

et al. 2010

View full text Add to dashboard Cite

show abstract

“…[163,[304][305][306][307][308][309][310][311][312] It is important to mention that the amine shells were attached to the PG core through carbamate linkers to induce pH-responsive cleavability of the shell fragment and consequent decomplexation of the genetic cargo.…”

Section: Scientific Goalsmentioning

confidence: 99%

siRNA transfection by dendritic core–shell nanocarriers

Fischer

Claderon

Ofek

et al. 2010

Journal of Controlled Release

Self Cite

View full text Add to dashboard Cite

show abstract

“…Therefore, dPGs have found many biomedical applications [11]. Our group has developed several core-shell architectures based on dPG as drug delivery systems [12][13][14][15][16][17][18]. Inspired by the polarity gradient of liposomes we designed core-multishell (CMS) architectures with either dendritic poly(ethylene imine) or dPG as core, a hydrophobic inner shell and a hydrophilic outer shell [19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Dendronized core-multishell nanocarriers for solubilization of guest molecules

Fleige¹,

Tyagi²,

Haag

2014

Nanocarriers

Self Cite

View full text Add to dashboard Cite

We have synthesized core-multishell (CMS) nanocarriers with different outer shells and the self-aggregation behavior and the transport capacity of these nanocarriers were studied with the hydrophobic guest molecules Nile red (NR) and methotrexate (MTX). The outer shell either consisted of methoxypoly(ethylene glycol) (mPEG) or polyglycerol (PG) dendrons of generation one or two. NR was solubilized by all CMS nanocarriers. The solubilization of MTX could only be achieved with mPEG-terminated CMS nanocarriers. Depending on the encapsulated guest, the CMS nanocarriers showed self-aggregation. The NR loaded CMS nanocarriers all formed bigger aggregates with a radius between 110 and 170 nm. In the case of the MTX loaded CMS nanocarriers, the MTX prevented the formation of CMS aggregates and therefore its efficient transport

show abstract

Development of pH-responsive core–shell nanocarriers for delivery of therapeutic and diagnostic agents

Cited by 77 publications

References 30 publications

Self‐Assembly of Hyperbranched Polymers and Its Biomedical Applications

Self‐Assembly of Hyperbranched Polymers and Its Biomedical Applications

siRNA transfection by dendritic core–shell nanocarriers

Dendronized core-multishell nanocarriers for solubilization of guest molecules

Contact Info

Product

Resources

About