Development of reference intervals for serum alkaline phosphatase among adults in Southern China traced to the new IFCC reference measurement procedure

Han, Liqiao; Wang, Jianbing; Zhang, Qiaoxuan; Ke, Peifeng; Wu, Xiaobin; Wan, Zemin; Lin, Haibiao; Zeng, Ruili; Huang, Xianzhang; Zhang, Junhua

doi:10.1515/cclm-2015-0732

Cited by 8 publications

(5 citation statements)

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“…Reference intervals for serum ALP in China were traced to the new IFCC reference procedure. 160 The results were higher than other populations. Hypercortisolism is frequently investigated because of the effects on bone health and body weight as discussed earlier in this review.…”

Section: Skeletonmentioning

confidence: 65%

Biochemistry of the menopause

Honour

2017

Ann Clin Biochem

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The life of a human female is characterized from teenage years by monthly menstruation which ceases (the menopause) typically between the age of 40 and 60 years. The potential for reproduction declines and ceases as the ovaries become depleted of follicles. A transition period in mid-life, for 2 to 10 years, when menstruation is less regular is called the perimenopause. The menopause is associated with a significant decline in plasma concentrations of sex hormones, an increase in the concentrations of the gonadotrophins and changes in other hormones such as the inhibins. These changes are superimposed with effects of aging, social and metabolic factors, daily activity and well-being. Although the menopause is entirely natural, in some cases ovarian failure can occur earlier than usual; this is pathological and warrants careful biochemical investigations to distinguish it from conditions causing infertility. Elderly females are affected by a range of clinical disorders including endocrine, cardiovascular, skeletal, urogenital tract and immunological systems, body mass, vasomotor tone, mood and sleep pattern. Reference intervals for many diagnostic biochemical tests for the menopause need to be used when interpreting results in clinical investigations for patient management. The standardization and harmonization of assays are being addressed. Many women now choose to develop their career before bearing children, and the health service has had to change services around this. This review does not cover screening for and tests during pregnancy. The review is timely since the population is aging and there will be more demand on healthcare services.

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Section: Skeletonmentioning

confidence: 65%

Biochemistry of the menopause

Honour

2017

Ann Clin Biochem

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“…The introduction of enzyme reference measurement systems to provide traceable patient results have therefore been followed by the definition of traceable reference intervals to provide more congruent and effective information to clinicians. In particular, traceable reference intervals have been established for AST, ALT, γGT, LDH, CK, alkaline phosphatase (ALP), and AMY first in Caucasian adults and afterwards in Asian individuals [17,18,[22][23][24][25][26]. Table 1 reports a synopsis of traceable reference intervals for enzymes obtained in European and Asian subjects.…”

Section: Introductionmentioning

confidence: 99%

Progress and impact of enzyme measurement standardization

Infusino

Frusciante

Braga

et al. 2017

Clinical Chemistry and Laboratory Medicine (CCLM)

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International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) has established reference measurement procedures (RMPs) for the most popular enzymes. Manufacturers should assign values to commercial calibrators traceable to these RMPs to achieve equivalent results in clinical samples, independent of reagent kits, instruments, and laboratory where the measurement is carried out. The situation is, however, far from acceptable. Some manufacturers continue to market assays giving results that are not traceable to internationally accepted RMPs. Meanwhile, end-users often do not abandon assays with demonstrated insufficient quality. Of the enzyme measurements, creatine kinase (CK) is satisfactorily standardized and a substantial improvement in performance of marketed γ-glutamyltranspeptidase (GGT) assays has been demonstrated. Conversely, aminotransferase measurements often exceed the desirable analytical performance because of the lack of pyridoxal-5-phosphate addition in the commercial reagents. Measurements of lactate dehydrogenase (LDH), alkaline phosphatase (ALP), and α-amylase (AMY) still show major disagreement, suggesting the need for improvement in implementing traceability to higher-order references. This is mainly the result of using assays with different analytical selectivities for these enzymes. The definition by laboratory professionals of the clinically acceptable measurement uncertainty for each enzyme together with the adoption by EQAS of commutable materials and use of an evaluation approach based on trueness represent the way forward for reaching standardization in clinical enzymology.

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“…Serum alkaline phosphatase in healthy children aged 0∼12 years from a hospital of Beijing in 2016 was reported at 112 ∼ 342 IU/L (Zhang et al, 2016). The reference interval of direct bilirubin (DBiL) and indirect bilirubin (IBiL) in healthy Han nationality children aged from January to 14 years in Changchun city was referenced (Li et al, 2016), with DBiL at 0∼6.7 μmol/L and IBiL at 5.4∼12.2 μmol/L.…”

Section: Resultsmentioning

confidence: 99%

“…Healthy alkaline phosphatase (ALP) value of children refers to the reference interval of serum ALP in healthy children aged 0∼12 years old from a hospital in Beijing (2016) (Zhang et al, 2016). In this article, the mean ALP before treatment was 212.9 ± 56.8 u/L and 212.2 ± 48.3 u/L after treatment, all within the normal range, and there was no difference before and after treatment ( p > .05).…”

Section: Discussionmentioning

confidence: 99%

Clinical case analysis of 32 children aged 0–6 years with lead poisoning in Nanning, China

Wei,

Gan,

et al. 2023

Toxicol Ind Health

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Lead is one of the heavy metals that is toxic and widely distributed in the environment, and children are more sensitive to the toxic effects of lead because the blood–brain barrier and immune system are not yet well developed. The objective of the study was to investigate the clinical characteristics of lead poisoning in children aged 0∼6 years in a hospital in Guangxi, and to provide scientific basis for the prevention and treatment of lead poisoning. We collected and analyzed the clinical data of 32 children with lead poisoning admitted to a hospital in Guangxi from 2010 to 2018. The results showed that most of the 32 cases presented with hyperactivity, irritability, poor appetite, abdominal pain, diarrhea, or constipation. The hemoglobin (HGB), mean corpusular volume (MCV), mean corpuscular hemoglobin (MCH), and hematocrit (HCT) of the lead-poisoned children were all decreased to different degrees and were below normal acceptable levels. Urinary β2-microglobulin was increased. Blood lead levels (BLL) decreased significantly after intravenous injection of the lead chelator, calcium disodium edetate (CaNa2-EDTA). In addition, HGB returned to normal levels, while MCV, MCH, and HCT increased but remained below normal levels. Urinary β2-microglobulin was reduced to normal levels. Therefore, in this cohort of children, the high-risk factors for lead poisoning are mainly Chinese medicines, such as baby powder. In conclusion, lead poisoning caused neurological damage and behavioral changes in children and decreased erythrocyte parameters, leading to digestive symptoms and renal impairment, which can be attenuated by CaNa2-EDTA treatment.

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Development of reference intervals for serum alkaline phosphatase among adults in Southern China traced to the new IFCC reference measurement procedure

Abstract: RIs for serum ALP for Chinese Han individuals in between the ages of 18 and 79 years were determined and required partitioning due to the higher ALP values of females age 50-79 years.

Cited by 8 publications

References 1 publication

Biochemistry of the menopause

Biochemistry of the menopause

Progress and impact of enzyme measurement standardization

Clinical case analysis of 32 children aged 0–6 years with lead poisoning in Nanning, China

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