Development of resveratrol loaded chitosan-gellan nanofiber as a novel gastrointestinal delivery system

Rostami, Mohammad Reza; Ghorbani, Marjan; Mohammadi, Masoud Aman; Delavar, Mostafa; Tabibiazar, Mahnaz; Ramezani, Soghra

doi:10.1016/j.ijbiomac.2019.05.187

Cited by 94 publications

(27 citation statements)

References 33 publications

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“…There are limited studies on the electrospinning of mixed polymers (chitosan and agarosetrifluoroacetic acid (TFA) solvent, chitosan, and gellan-TFA solvent ). [33][34][35] The obtained result of this study about spinnability is in agreement with other studies in which the spinnability of chitosan increased in the presence of agarose and gellan. Thus, electrospinning productivity improved with optimum values of conductivity and chitosan-gelatin solution's viscosity, which was attained at a defined concentration ratio.…”

Section: Electrospinning and Physicochemical Properties Of Chitosan-gsupporting

confidence: 92%

“…The patterns related to the gelatin structure and vibrations of C=O and N-H bonds in amide I, as well as vibrations of C≡N and N-H groups in amides II and III, also appeared at around 1633 cm -1 , 1583 cm -1 , and 1238 cm -1 . 35 The peaks which appeared in 1518 cm -1 were attributed to the vibration mode of the N-H band in amide II, and the peak appearing at shorter wavelengths indicated N-H vibration of NH3 group in the chitosan structure. 37 The change in the intensity and location of the peaks is 5 to 10 cm -1 , which is an evidence for the presence of both materials and the successful preparation of the two-component NFs.…”

Section: Ft-irmentioning

confidence: 97%

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Evaluation of Design and Fabrication of Food-Grade Nanofibers from Chitosan-Gelatin for Nanoencapsulation of Stigmasterol Using the Electrospinning Method

et al. 2020

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Purpose: In this research, electrospinning method was employed to fabricate food-grade nanofibers (NFs) from chitosan-gelatin combination for stigmasterol encapsulation. The spinnability of mixed chitosan and gelatin solutions was investigated at different polymer ratios, and the physicochemical properties of the NFs were evaluated. Methods: The mixture solution of chitosan (1.5 % w/v) and gelatin (20 % w/v) in acetic acid indicated spinnability under the following conditions: the ratio of 25:75, voltage of 17 kV, and 15 cm capillary collector distance with a flow rate of 0.2 mL/min. Stigmasterol (0.04 % w/v) was incorporated into NFs of chitosan-gelatin at a respective ratio of 25:75. Results: Encapsulation efficiency (EE) of loaded stigmasterol was found to be 87 ± 5 %. The antioxidant ability of loaded stigmasterol was considerably higher than that observed for free stigmasterol. Scanning electron microscopy (SEM) results demonstrated the formation of the ultrathin fibers with no bead (with diameters of 217 ± 43 nm). The concentration of polymeric solution and viscosity had a notable effect on the electrospinning efficiency of the chitosan-gelatin-based nanofibers. The thermal stability of chitosan and gelatin fibers was more than that of native gelatin and chitosan. The in vitro stigmasterol release from these nanofibers followed a controlled-release pattern. The released phytosterol from chitosan formula was less than from those without chitosan formula (46 ± 3 % and 96 ± 4 % respectively). Conclusion: The obtained results suggested that gelatin had a high potential for enhancing the spinnability of chitosan under acidic conditions at optimized concentrations.

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Section: Electrospinning and Physicochemical Properties Of Chitosan-gsupporting

confidence: 92%

Section: Ft-irmentioning

confidence: 97%

Evaluation of Design and Fabrication of Food-Grade Nanofibers from Chitosan-Gelatin for Nanoencapsulation of Stigmasterol Using the Electrospinning Method

et al. 2020

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“…The characteristic peak of NS was observed at 1743 cm −1 because of the stretching vibrations of the carbonyl group. RES showed characteristic vibrations at 3209 cm −1 (O–H stretching), 3019 cm −1 (C–H stretching of phenyl ring), 1605 cm −1 (C=C stretching), 1322 cm −1 (O–H bending) [37].…”

Section: Resultsmentioning

confidence: 99%

Comparative Evaluation of Solubility, Cytotoxicity and Photostability Studies of Resveratrol and Oxyresveratrol Loaded Nanosponges

et al. 2019

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Resveratrol and oxyresveratrol are natural polyphenolic stilbenes with several important pharmacological activities. However, low solubility and aqueous instability are the major limitations in their drug delivery applications. In the present work, we demonstrated the encapsulation of resveratrol and oxyresveratrol with nanosponge to improve solubility and stability. Several characterization techniques were used to confirm the encapsulation of both drug molecules within the nanosponges. The high encapsulation efficiency of resveratrol (77.73%) and oxyresveratrol (80.33%) was achieved within the nanosponges. Transmission electron microscopy suggested uniform spherical size particles of resveratrol and oxyresveratrol loaded nanosponges. Compared to free drugs, better protection against UV degradation was observed for resveratrol-loaded nanosponge (2-fold) and oxyresveratrol-loaded nanosponge (3-fold). Moreover, a higher solubilization of resveratrol- and oxyresveratrol-loaded nanosponges lead to a better antioxidant activity compared to drug molecules alone. Cytotoxicity studies against DU-145 prostate cancer cell lines further suggested improved activity of both resveratrol and oxyresveratrol-loaded nanosponges without any significant toxicity of blank nanosponges.

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“…Their biocompatibility and cell adhesion studies were confirmed by culturing with human dermal fibroblast (3T3L1) cells. A recent study, using resveratrol loaded chitosan/GG nanofibers as a novel gastrointestinal delivery system [87], highlighted that the encapsulation efficacy of resveratrol was 86 ± 6%. Antioxidant activities of resveratrol loaded nanofiber material were significantly higher than controls, and based on these findings, the authors suggested that prepared GG/chitosan resveratrol loaded nanofibers hold great potential as a drug delivery carrier.…”

Section: Gellan Gum In Drug Deliverymentioning

confidence: 99%

Biological Role of Gellan Gum in Improving Scaffold Drug Delivery, Cell Adhesion Properties for Tissue Engineering Applications

2019

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Over the past few decades, gellan gum (GG) has attracted substantial research interest in several fields including biomedical and clinical applications. The GG has highly versatile properties like easy bio-fabrication, tunable mechanical, cell adhesion, biocompatibility, biodegradability, drug delivery, and is easy to functionalize. These properties have put forth GG as a promising material in tissue engineering and regenerative medicine fields. Nevertheless, GG alone has poor mechanical strength, stability, and a high gelling temperature in physiological conditions. However, GG physiochemical properties can be enhanced by blending them with other polymers like chitosan, agar, sodium alginate, starch, cellulose, pullulan, polyvinyl chloride, xanthan gum, and other nanomaterials, like gold, silver, or composites. In this review article, we discuss the comprehensive overview and different strategies for the preparation of GG based biomaterial, hydrogels, and scaffolds for drug delivery, wound healing, antimicrobial activity, and cell adhesion. In addition, we have given special attention to tissue engineering applications of GG, which can be combined with another natural, synthetic polymers and nanoparticles, and other composites materials. Overall, this review article clearly presents a summary of the recent advances in research studies on GG for different biomedical applications.

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Development of resveratrol loaded chitosan-gellan nanofiber as a novel gastrointestinal delivery system

Cited by 94 publications

References 33 publications

Evaluation of Design and Fabrication of Food-Grade Nanofibers from Chitosan-Gelatin for Nanoencapsulation of Stigmasterol Using the Electrospinning Method

Evaluation of Design and Fabrication of Food-Grade Nanofibers from Chitosan-Gelatin for Nanoencapsulation of Stigmasterol Using the Electrospinning Method

Comparative Evaluation of Solubility, Cytotoxicity and Photostability Studies of Resveratrol and Oxyresveratrol Loaded Nanosponges

Biological Role of Gellan Gum in Improving Scaffold Drug Delivery, Cell Adhesion Properties for Tissue Engineering Applications

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Development of resveratrol loaded chitosan-gellan nanofiber as a novel gastrointestinal delivery system

Cited by 94 publications

References 33 publications

­­­­Evaluation of Design and Fabrication of Food-Grade Nanofibers from Chitosan-Gelatin for Nanoencapsulation of Stigmasterol Using the Electrospinning Method

­­­­Evaluation of Design and Fabrication of Food-Grade Nanofibers from Chitosan-Gelatin for Nanoencapsulation of Stigmasterol Using the Electrospinning Method

Comparative Evaluation of Solubility, Cytotoxicity and Photostability Studies of Resveratrol and Oxyresveratrol Loaded Nanosponges

Biological Role of Gellan Gum in Improving Scaffold Drug Delivery, Cell Adhesion Properties for Tissue Engineering Applications

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Product

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Evaluation of Design and Fabrication of Food-Grade Nanofibers from Chitosan-Gelatin for Nanoencapsulation of Stigmasterol Using the Electrospinning Method

Evaluation of Design and Fabrication of Food-Grade Nanofibers from Chitosan-Gelatin for Nanoencapsulation of Stigmasterol Using the Electrospinning Method