Development of Ru-polypyridyl complexes for real-time monitoring of Aβ oligomers and inhibition of Aβ fibril formation

Chen, Xian; Wang, Jiaoyang; Mo, Zhenzhuo; Han, Lu; Cheng, Kaiqing; Xie, Cheng; Liu, Genyan; Jiang, Lijun; Wang, Kai; Pan, Jie

doi:10.1039/d3bm01929b

Cited by 2 publications

(1 citation statement)

References 31 publications

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“…Despite the appealing MoA, most of the metal-based complexes reported so far (structures as shown in Chart ) can only be activated by blue or green light, limiting the tissue penetration depth of phototherapy. − For example, green (blue) light-excited TLD 1433, which recently entered phase-II clinical trials with FDA-fast-track approval, was only applicable for superficial bladder cancer . The near-infrared (NIR, 650–900 nm) light is more useful for deep-seated tumor treatment due to the much-enhanced tissue penetration ability. , Currently, padeliporfin potassium (TOOKAD Soluble) is the only metal-based PDT drug available in the market for localized prostate cancer treatment under 753 nm light exposure .…”

Section: Introductionmentioning

confidence: 99%

Dinuclear Tridentate Ru(II) Complex with Strong Near-Infrared Light-Triggered Anticancer Activity

Wei,

Kushwaha,

Sadhukhan

et al. 2024

J. Med. Chem.

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The design of the dinuclear Ru(II) complex (Ru2) with strong near-infrared (NIR) absorption properties has been reported for efficient anticancer phototherapy. Under 700 nm LED light excitation, Ru2 exhibited remarkable synergistic type I/II photosensitization ability and photocatalytic activity toward intracellular biomolecules. Ru2 showed impressive 700 nm lighttriggered anticancer activity under normoxia and hypoxia compared with the clinically used photosensitizer Chlorin e6. The mechanistic studies showed that Ru2 induced intracellular redox imbalance and perturbed the energy metabolism and biosynthesis in A549 cancer cells. Overall, this work provides a new strategy for developing efficient metal-based complexes for anticancer phototherapy under NIR light.

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Section: Introductionmentioning

confidence: 99%

Dinuclear Tridentate Ru(II) Complex with Strong Near-Infrared Light-Triggered Anticancer Activity

Wei,

Kushwaha,

Sadhukhan

et al. 2024

J. Med. Chem.

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Mechanism of Metal Complexes in Alzheimer’s Disease

Liu,

Ma,

Zhang

et al. 2024

IJMS

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Alzheimer’s disease (AD) is a kind of neurodegenerative diseases characterized by beta-amyloid deposition and neurofibrillary tangles and is also the main cause of dementia. According to statistics, the incidence of AD is constantly increasing, bringing a great burden to individuals and society. Nonetheless, there is no cure for AD, and the available drugs are very limited apart from cholinesterase inhibitors and N-Methyl-D-aspartic acid (NMDA) antagonists, which merely alleviate symptoms without delaying the progression of the disease. Therefore, there is an urgent need to develop a medicine that can delay the progression of AD or cure it. In recent years, increasing evidence suggests that metal complexes have the enormous potential to treat AD through inhibiting the aggregation and cytotoxicity of Aβ, interfering with the congregation and hyperphosphorylation of tau, regulating dysfunctional synaptic and unbalanced neurotransmitters, etc. In this review, we summarize the current metal complexes and their mechanisms of action for treating AD, including ruthenium, platinum, zinc, vanadium, copper, magnesium, and other complexes.

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Development of Ru-polypyridyl complexes for real-time monitoring of Aβ oligomers and inhibition of Aβ fibril formation

Abstract: Two Ru complexes, Ru-WJ and Ru-YH, were designed and synthesized to detect Aβ aggregates at an early AD stage. Ru-WJ and Ru-YH could quickly cross the BBB of young AD mice. Ru-YH can also inhibit the growth of Aβ.

Cited by 2 publications

References 31 publications

Dinuclear Tridentate Ru(II) Complex with Strong Near-Infrared Light-Triggered Anticancer Activity

Dinuclear Tridentate Ru(II) Complex with Strong Near-Infrared Light-Triggered Anticancer Activity

Mechanism of Metal Complexes in Alzheimer’s Disease

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