Development of Selective Ligands for Pac1, Vpac1 and Vpac2 Receptors

Robberecht, Patrick; Vertongen, Pascale; Langer, Ingrid; Perret, Jason

doi:10.1007/978-1-4615-0243-2_3

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2009

2016

Publication Types

Select...

Article1

Book1

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

(1 citation statement)

References 99 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most of the structure-activity relationship studies focusing on type II receptor so far have been carried out with VIP derivatives and have contributed to the development of pharmacological tools that discriminate between VPAC1-R and VPAC2-R (Table 4) (Robberecht et al, 2003;Laburthe and Couvineau, 2002;Laburthe et al, 2003;Couvineau et al, 2006). N-terminally truncated analogs of PACAP show a preference for VPAC2-R. For instance, the PACAP(6 -38) fragment exhibits a 15-fold higher affinity for VPAC2-R than for VPAC1-R (Gourlet et al, 1995), whereas PACAP(1-25) possesses a 66-fold higher affinity for VPAC1-R than for VPAC2-R .…”

mentioning

confidence: 99%