Development of Sensitive Spectrophotometric Method for Analysis of Darifenacin Hydrobromide Liposomes in Rat Plasma

Babu, Nayaka Raghavendra; Padmavathi, Yenumula; Priyanka, S.; Kumar, Praveen

doi:10.5958/2231-5675.2017.00008.4

Cited by 7 publications

(2 citation statements)

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“…Literature reviewrevealed that several spectrophotometric [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] and liquid chromatographic (LC) [21][22][23][24] methods were reported for the determination of famciclovir in bulk drug and pharmaceutical dosage forms.Drug of a particular composition is marketed with various brand names. Minimal changes in the chemical composition and standard of the drug will have a profound effect on the physiological and biological activities of the patient.…”

Section: Introductionmentioning

confidence: 99%

Development of New Sensitive Spectrophotometric Method for Estimation of Famciclovir Using 3-Amino Phenol

Babu,

Divya,

Padmavathi

et al. 2023

Asian J Pharm Res Dev

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The study aims to find out the effectiveness of the combination of citral and curcumin as antifungal compounds. Lemongrass (Cymbopogon citratus) is a valuable family of grass known due to its flavoring, medicinal, and fragrance application. Haldi (Turmeric) scientifically known as Curcuma longa belongs to familthey Zingiberaceae. Its polyphenolic compound curcumin has been showing a variety of antifungal investigations due to extensive traditional uses and very low side effects.Turmeric has beenutilized in traditional medicine for various diseases counting diabetes, hepatitis, hemorrhoids, hysteria, indigestion, skin disease, inflammation, anorexia, hepatic disorders, cough, and sinusitis. In this formulation substudy combination of two bioactive oils is considered to form an effective antifungal spray preparation. The spray preparation is helpful to achieve fast absorption of the drugs through the transdermal way of drug administration. The effectiveness and activity rate of spray preparation is more beneficial. Lemongrass oil and curcumin are dissolved in ethanol to form a stable, safe, and effective spray formulation.

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Section: Introductionmentioning

confidence: 99%

Development of New Sensitive Spectrophotometric Method for Estimation of Famciclovir Using 3-Amino Phenol

Babu,

Divya,

Padmavathi

et al. 2023

Asian J Pharm Res Dev

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“…10 Darifenacin monitoring in formulations for pharmaceuticals and biological fluids was mostly accomplished using chromatographic and spectrophotometric methods. [11][12][13][14][15][16][17][18][19][20][21] The lack of selectivity and limited sensitivity in the case of biological samples represents the main obstacle of the spectrophotometric techniques. Even the chromatographic approaches succeeded in sensitive monitoring of DFC and its degradation products in pharmaceutical and biological samples, the requirement of expert personnel for the pretreatment and handling of the sample with sophisticated and tedious conditions obstacles the application of such techniques for large-scale samples analysis.…”

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confidence: 99%

Zinc Oxide Nanostructured-Based Sensors for Anodic Stripping Voltammetric Determination of Darifenacin

Al‐Qahtani

Hameed

Alamrani

et al. 2022

J. Electrochem. Soc.

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Herein for the first time, the construction and the electroanalytical applications of novel darifenacin (DFC) voltammetric sensors were described. Zinc oxide nanostructures act as a proper redox mediator and exhibit efficient catalytic activity towards the electrooxidation of the DFC molecule. At the optimum measuring conditions, DFC exhibited an irreversible anodic oxidation peak at 0.880 V with an assumed adsorption-reaction mechanism at the electrode surface. Based on the effect of the pH and the scan rate studies, electrooxidation of DFC takes place through the oxidation of the nitrogen atom (N12) in the five-membered ring of the darifenacin molecule with the participation of one electron and one proton in agreement with the molecular orbital calculations. Calibration curves were linear within the DFC concentration ranging from 0.33 to 6.54×10-6 mol L-1 with a limit of detection (LOD) and limit of quantification (LOQ) values of 0.08 and 0.23×10-6 mol L-1. The proposed sensors exhibited enhanced performance with high measurement reproducibility and prolonged lifetime. The presented voltammetric approach was utilized for precise determination of darifenacin in biological samples and pharmaceutical formulations with acceptable recoveries compared with the traditional spectrophotometric methods.

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A Bioanalytical Method for Quantification of Telmisartan in rat Plasma; Development, Validation and Application to Pharmacokinetic Study

AL-Japairai

Chatterjee

Mahmood

et al. 2021

RJPT

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The telmisartan was determined in a rat plasma using developed and validated a reversed-phase high performance liquid chromatographic (HPLC). The pre-treatment of the plasma sample involving liquid-liquid extraction using ethanol as the extracting solvent. The HPLC method validation has been shown a linear calibration curve over a plasma concentrations range of 0.7 to 10µg/mL with a correlation coefficient of 0.9979, the limit of detection and the limit of quantification were determined to be 0.025µg/ml and 0.07µg/ml, respectively. The precision and accuracy were in an acceptable limit. The pharmacokinetic parameters of telmisartan were adequately evaluated following a single oral dose (4mg/kg) in Sprague-Dawley rats. The results observed conclude that the developed bioanalytical HPLC method is appropriate and applicable as an analytical tool in the pharmacokinetic study of telmisartan.

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Development of Sensitive Spectrophotometric Method for Analysis of Darifenacin Hydrobromide Liposomes in Rat Plasma

Cited by 7 publications

References 0 publications

Development of New Sensitive Spectrophotometric Method for Estimation of Famciclovir Using 3-Amino Phenol

Development of New Sensitive Spectrophotometric Method for Estimation of Famciclovir Using 3-Amino Phenol

Zinc Oxide Nanostructured-Based Sensors for Anodic Stripping Voltammetric Determination of Darifenacin

A Bioanalytical Method for Quantification of Telmisartan in rat Plasma; Development, Validation and Application to Pharmacokinetic Study

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