Development of single- and two-tone responses of anteroventral cochlear nucleus neurons in gerbil

Konrad-Martin, Dawn; Rübsamen, Rudolf; Dörrscheidt, G. J.; Rubel, Edwin W.

doi:10.1016/s0378-5955(98)00063-x

Cited by 2 publications

(2 citation statements)

References 58 publications

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“…Local inhibition is typically characterized by the effects of off-CF tones on spontaneous activity. Also the two-tone stimulation paradigm is commonly used to evaluate the local inhibition on the level of the cochlear nucleus (CN) [41–43], the IC [44, 45], and the auditory cortex (AC) [46]. Using the two-tone stimulation, the contribution of cochlear suppression cannot be excluded in the current study.…”

Section: Methodsmentioning

confidence: 99%

BDNF in Lower Brain Parts Modifies Auditory Fiber Activity to Gain Fidelity but Increases the Risk for Generation of Central Noise After Injury

et al. 2015

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For all sensory organs, the establishment of spatial and temporal cortical resolution is assumed to be initiated by the first sensory experience and a BDNF-dependent increase in intracortical inhibition. To address the potential of cortical BDNF for sound processing, we used mice with a conditional deletion of BDNF in which Cre expression was under the control of the Pax2 or TrkC promoter. BDNF deletion profiles between these mice differ in the organ of Corti (BDNFPax2-KO) versus the auditory cortex and hippocampus (BDNFTrkC-KO). We demonstrate that BDNFPax2-KO but not BDNFTrkC-KO mice exhibit reduced sound-evoked suprathreshold ABR waves at the level of the auditory nerve (wave I) and inferior colliculus (IC) (wave IV), indicating that BDNF in lower brain regions but not in the auditory cortex improves sound sensitivity during hearing onset. Extracellular recording of IC neurons of BDNFPax2 mutant mice revealed that the reduced sensitivity of auditory fibers in these mice went hand in hand with elevated thresholds, reduced dynamic range, prolonged latency, and increased inhibitory strength in IC neurons. Reduced parvalbumin-positive contacts were found in the ascending auditory circuit, including the auditory cortex and hippocampus of BDNFPax2-KO, but not of BDNFTrkC-KO mice. Also, BDNFPax2-WT but not BDNFPax2-KO mice did lose basal inhibitory strength in IC neurons after acoustic trauma. These findings suggest that BDNF in the lower parts of the auditory system drives auditory fidelity along the entire ascending pathway up to the cortex by increasing inhibitory strength in behaviorally relevant frequency regions. Fidelity and inhibitory strength can be lost following auditory nerve injury leading to diminished sensory outcome and increased central noise.

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Section: Methodsmentioning

confidence: 99%

BDNF in Lower Brain Parts Modifies Auditory Fiber Activity to Gain Fidelity but Increases the Risk for Generation of Central Noise After Injury

et al. 2015

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“…Thus, it is likely that thalamocortical inputs contribute significantly to the observed cellular inhibitory sidebands. Moreover, as sideband inhibition originates from the auditory periphery (Ruggero et al, 1992) and can be observed at other stages in the ascending auditory pathway (Konrad-Martin et al, 1998;Jen et al, 2002), we consider the inhibition seen in A1 as functionally diverse with aspects partially generated de novo in A1.…”

Section: Discussionmentioning

confidence: 99%

Diversity of Receptive Fields and Sideband Inhibition with Complex Thalamocortical and Intracortical Origin in L2/3 of Mouse Primary Auditory Cortex

Liu

2021

J. Neurosci.

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Receptive fields of primary auditory cortex (A1) neurons show excitatory neuronal frequency preference and diverse inhibitory sidebands. While the frequency preferences of excitatory neurons in local A1 areas can be heterogeneous, those of inhibitory neurons are more homogeneous. To date, the diversity and the origin of inhibitory sidebands in local neuronal populations and the relation between local cellular frequency preference and inhibitory sidebands are unknown. To reveal both excitatory and inhibitory subfields, we presented two-tone and pure tone stimuli while imaging excitatory neurons (Thy1) and two types of inhibitory neurons (parvalbumin and somatostatin) in L2/3 of mice A1. We classified neurons into six classes based on frequency response area (FRA) shapes and sideband inhibition depended both on FRA shapes and cell types. Sideband inhibition showed higher local heterogeneity than frequency tuning, suggesting that sideband inhibition originates from diverse sources of local and distant neurons. Two-tone interactions depended on neuron subclasses with excitatory neurons showing the most nonlinearity. Onset and offset neurons showed dissimilar spectral integration, suggesting differing circuits processing sound onset and offset. These results suggest that excitatory neurons integrate complex and nonuniform inhibitory input. Thalamocortical terminals also exhibited sideband inhibition, but with different properties from those of cortical neurons. Thus, some components of sideband inhibition are inherited from thalamocortical inputs and are further modified by converging intracortical circuits. The combined heterogeneity of frequency tuning and diverse sideband inhibition facilitates complex spectral shape encoding and allows for rapid and extensive plasticity.

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Development of single- and two-tone responses of anteroventral cochlear nucleus neurons in gerbil

Cited by 2 publications

References 58 publications

BDNF in Lower Brain Parts Modifies Auditory Fiber Activity to Gain Fidelity but Increases the Risk for Generation of Central Noise After Injury

BDNF in Lower Brain Parts Modifies Auditory Fiber Activity to Gain Fidelity but Increases the Risk for Generation of Central Noise After Injury

Diversity of Receptive Fields and Sideband Inhibition with Complex Thalamocortical and Intracortical Origin in L2/3 of Mouse Primary Auditory Cortex

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