Development of Small Diameter Vascular Prostheses

Dj, Lyman; Albo, Dominic; Jackson, Romeo; Knutson, K.

doi:10.1097/00002480-197700230-00067

Cited by 63 publications

(12 citation statements)

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“…Because of this reduced wall density, the compliance of the tube could be made to approximate that of the natural artery. The results of the initial implants of these compliant grafts supported our hypothesis [11,12]. That is, in contrast to the noncompliant solid wall prostheses which failed within hours, six of the nine compliant prostheses were patent on removal at times ranging from four to seventy-seven days.…”

Section: Vascular Prosthesessupporting

confidence: 75%

Bulk and Surface Effects on Blood Compatibility

Lyman

1991

Journal of Bioactive and Compatible Polymers

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Studies on protein adsorption and platelet adhesion indicate that polymer surfaces can selectively adsorb proteins from whole blood in vivo and the composition of this adsorbed protein layer influences the adhesion of platelets, and thus determines the thrombogenicity of the polymer. The microphase structure of the block copolyurethanes seems to often confer a selectivity in albumin adsorption, which appears to make these materials relatively nonthrombogenic Analyses of the synthetic procedures for preparing these block copolyurethanes have indicated that the standard two-step synthetic procedure introduces sizeable amounts of dimeric soft and hard segments into the copolymers. FT-IR and ESCA are being used to determine the bulk and surface morphology of these standard block copolyurethanes as well as their pure (AB) n analogs, so as to understand protein binding to their surfaces. A study of these materials as vascular grafts has indicated that the bulk properties (i.e., the compliance of the graft) can also affect graft patency under in vivo conditions.

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Section: Vascular Prosthesessupporting

confidence: 75%

Bulk and Surface Effects on Blood Compatibility

Lyman

1991

Journal of Bioactive and Compatible Polymers

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“…For this reason the different steps and mechanisms involved in SNIPS are discussed with more detail, as well as the most recent developments and suggestions for future work. Non-porous block copolymer membranes and coatings Lyman et al 1,2 were probably the first to report on block copolymer membranes. They developed synthetic membranes from poly (ethylene oxide) (PEO) and poly (ethylene terephthalate) block copolymer for blood dialysis.…”

Section: Introductionmentioning

confidence: 99%

Block Copolymer Membranes for Aqueous Solution Applications

2016

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Block copolymers are known for their intricate morphology. We review the state of the art of block copolymer membranes and discuss perspectives in this field. The main focus is on pore morphology tuning with a short introduction on non-porous membranes. The two main strategies for pore formation in block copolymer membranes are (i) film casting and selective block sacrifice and (ii) self-assembly and non-solvent induced phase separation (SNIPS). Different fundamental aspects involved in the manufacture of block copolymer membranes are considered, including factors affecting the equilibrium morphology in solid films, self-assembly of copolymer in solutions and macrophase separation by solvent-non-solvent exchange. Different mechanisms are proposed for different depths of the SNIPS membrane. Block copolymer membranes can be prepared with much narrower pore size distribution than homopolymer membranes. Open questions and indications of what we consider the next development steps are finally discussed. They include the synthesis and application of new copolymers and specific functionalization, adding characteristics to respond to stimuli and chemical environment, polymerization-induced phase separation, and the manufacture of organic-inorganic hybrids.3

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“…Failure of Arterial Bypass Grafts he most serious acute problem for small diameter synthetic Tvascular grafts is thrombosis [1,2]. Thrombosis has been reported to cause failure in 20% of e-PTFE grafts within the first month after implantation [2].…”

Section: Introductionmentioning

confidence: 99%

Effect of Controlled Local Acetylsalicylic Acid Release on in vitro Platelet Adhesion to Vascular Grafts

1994

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Thrombosis is the most serious acute problem for small diameter arterial bypass grafts. In this research, small diameter expanded polytetrafluoroethylene (e-PTFE) vascular grafts were coated with acetylsalicylic acid (ASA) loaded poly (d,l-lactide) (PLA) by a solvent casting method. The feasibility and efficacy of this approach were evaluated by ASA release studies and platelet adhesion tests. First, the ASA release kinetics were evaluated from the ASA/PLA coated vascular grafts in an in vitro steady flow loop model. ASA release was measured by a spectrophotometric technique. Finally, the efficacy of local ASA release to reduce in vitro canine platelet adhesion to grafts was determined with epifluorescent video microscopy and quantitative image analysis. The steady state release rates from the 5%, 10%, and 15% ASA/PLA coated grafts were 13.2 x 10(-5), 32.0 x 10(-5), and 41.5 x 10(-5) micrograms/cm2.sec, respectively. Platelet adhesion to 10% and 15% ASA/PLA coated grafts was reduced with respect to the control and 5% grafts for 10 days. Platelet adhesion to 5% ASA/PLA coated grafts was reduced with respect to controls at 2 and 10 days, but not initially.

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Development of Small Diameter Vascular Prostheses

Cited by 63 publications

References 0 publications

Bulk and Surface Effects on Blood Compatibility

Bulk and Surface Effects on Blood Compatibility

Block Copolymer Membranes for Aqueous Solution Applications

Effect of Controlled Local Acetylsalicylic Acid Release on in vitro Platelet Adhesion to Vascular Grafts

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