Development of Stereoselective Method for the Quantification of Stereoisomers and Geometrical Isomer of Pitavastatin Calcium by Enhanced Approach

State-of-the-art and recent developments of immobilized polysaccharide-based chiral stationary phases for enantioseparations by high-performance liquid chromatography (2013–2017)

“…have also been determined, especially in commercial products or biological samples (pharmaceutical formulations, human urine, human or animal blood, human plasma, animal serum, etc.). Another heterogeneous group of analytes, including connectors for building metal-organic frameworks [116,117,124], intermediates for the synthesis of pharmaceuticals [111], natural and synthetic compounds [39,113,121,120], biological compounds [82,112,58,71,78,86,[61][62][63]77,75], natural alkaloids [121], biomolecules [115,54], organometallic compounds [119] and chiral metabolites [103,108,100,97,102,59,63,52] has been enantioseparated with these immobilized polysaccharides CSPs (see Table 2-4). Fig.…”

“…The additives are usually used at very low proportion (0.05-0.5%, v/v) and include mainly diethylamine (DEA), triethylamine (TEA), isopropylamine (iPA), 2-aminoethanol (AE), ethylenediamine (EDA) or trifluoroacetic acid (TFA), acetic acid (AA) and formic acid (FA). Among the basic additives, DEA is the most commonly used and has proved to be effective for screening and method development of many basic compounds [40,50,51,67,68,60,74,73,55,84,95,111,58,78,62,75,122,87,93,80] (see Tables 2-4). As a general rule, basic additives are employed for enantiomer separation of basic compounds, while acidic additives are essential for acidic ones.…”

“…Several studies carried out on certain polysaccharide-based CSPs of immobilized type showed significant effects of acidic additive (or acidic with basic mixture additive) mainly on basic compounds [41,103,104,108,101,73,53,95,90,91,58,86,63,115,52] (see Tables 2-4).…”