With the continuous improvement of people's living standards and the growing material and cultural needs, people have become inseparable from the convenience brought by chemical products. There are flammable, explosive, toxic and hazardous substances in the production of these chemical products, which can easily cause a series of production safety accidents if not well managed, so the safety management of petrochemical enterprises is particularly important. Based on the HSE management system and combined with relevant theories, this paper describes the current safety situation and characteristics of the petrochemical industry, explores the current safety hazards, and proposes corresponding countermeasures to solve them.