Development of the brainstem auditory pathway in low birthweight and perinatally asphyxiated children with neurological sequelae

Zhang, L.; Jiang, Ze D.

doi:10.1016/0378-3782(92)90087-w

Cited by 13 publications

(6 citation statements)

References 27 publications

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“…Na verdade os recém nascidos de muito baixo peso (menor que 1500g) apresentam outros fatores de risco, que não é só o baixo peso ao nasci- Estudos em recém-nascidos com peso de nascimento inferior a 2500g e anoxiados, encontraram uma incidência de 11 a 19% de seqüela neurológica e comprometimento auditivo neurossensorial, sugerindo que a anóxia perinatal e as complicações associadas a ela podem ser responsáveis pela perda auditiva 20 . Estudos histopatológicos mostram perdas celulares do núcleo coclear após anoxia neonatal grave 21 .…”

Section: Discussionunclassified

Avaliação do comportamento auditivo e neuropsicomotor em lactentes de baixo peso ao nascimento

Lichtig¹,

Monteiro²,

Couto³

et al. 2001

Rev. Assoc. Med. Bras.

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INTRODUÇÃOA função auditiva é considerada uma peça fundamental do complexo sistema de comunicação do ser humano. A integridade e o funcionamento adequado dos órgãos responsáveis pela audição e pela fala são pré-requisitos fundamentais para garantir a aquisição da linguagem.O desenvolvimento do sistema auditivo periférico está completo no quinto mês de vida intra-uterina, tanto anatômica quanto fisiologicamente. Portanto, é possível e passível estudá-lo nos períodos pré-natal, neonatal e pós-natal. Neste estudo, focalizaremos apenas a avaliação auditiva no período pós-natal.O sistema auditivo central está menos CONCLUSÃO. Concluiu-se que 5% dos lactentes apresentaram atraso na localização auditiva da fonte sonora e que os atendimentos médico e fonoaudiológico precoces, no berçário e ambulató-rio, nos dois primeiros anos de vida destas crianças de alto -risco são necessários.UNITERMOS: Prematuros. Deficiência auditiva. Localização da fonte sonora. Desenvolvimento neuropsicomotor. desenvolvido no período neonatal, o que ocorre gradativamente até a fase adulta. Para estudar o nível de maturação deste sistema no período neonatal durante os 23 meses seguintes, pesquisadores recorrem aos testes de percepção auditiva, como por exemplo, de discriminação dos sons da fala 1,2 e da localização da fonte sonora [3][4][5][6] .Alguns métodos utilizados para a avaliação auditiva em neonatos, como por exemplo a audiometria de respostas elétricas do tronco cerebral (BERA), emissões otoacústicas e outros, apresentam como vantagens a objetividade e participação de apenas um profissional para realização do teste. Por outro lado, apresentam desvantagens como o alto custo do equipamento, sua manutenção e análise dos traçados.Outros métodos para avaliação auditiva são testes que avaliam as respostas auditivas comportamentais, obtendo-se respostas claras e seguras para uma variedade de estímulos auditivos, onde o espectro e intensidades do sinal são conhecidos 7 . Tal método possibilita fornecer informações relativas ao grau de maturação do sistema nervoso central. Considerando-se a realidade brasileira, no que tange a precariedade dos recursos na área da saúde pública, os métodos comportamentais são mais compatíveis e viáveis neste momento devido ao seu baixo custo, simplicidade no manuseio e sua fácil manutenção.Os objetivos deste estudo foram detectar a presença de deficiência auditiva (DA) de moderada a profunda em lactentes de baixo peso ao nascimento, e na ausência desta, acompanhar o desenvolvimento da função auditiva (localização da fonte sonora), e acompanhar o desenvolvimento neuropsicomotor destas crianças durante os dois primeiros anos de vida. Para isto foram acompanhados 60 lactentes considerados

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Section: Discussionunclassified

Avaliação do comportamento auditivo e neuropsicomotor em lactentes de baixo peso ao nascimento

Lichtig¹,

Monteiro²,

Couto³

et al. 2001

Rev. Assoc. Med. Bras.

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“…The younger the fetus, the more chances of brain cell damage caused by various conditions due to immature development (7,34). Infants in these previous studies exhibited lower auditory function scores in the first year of infancy, and this was correlated with their lower MDI/PDI indicators of cognitive and motor development.…”

Section: Baep Value Predicts MDI Score In Premature Infantsmentioning

confidence: 89%

Prediction of Delayed Neurodevelopment in Infants Using Brainstem Auditory Evoked Potentials and the Bayley II Scales

et al. 2020

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Background: Brainstem auditory evoked potentials (BAEP) provide an objective analysis of central nervous system function and development in infants. This study proposed to examine the relationship between infant BAEP values at age 6 months, and their neurodevelopment at age 2 years assessed by the mental development indices (MDI), a form of Bayley Scales of Infant Development. We hypothesized that in infants with BAEP values outside normal range, there may be neurodevelopmental delays, as shown by their MDI scores. Methods: An exploratory investigation was conducted using preterm (28-36 weeks gestation; 95 cases) and term infants (≥37 weeks gestation; 100 cases) who were born with specific perinatal conditions. BAEP values were recorded in these infants from 1 to 8 months of age, and compared with MDI scores in these infants at age 2 years. A multivariate linear regressions model was performed to test the associations between all variables and MDI scores. Stratified linear regression was used to test the interactions between gestational age and BAEP values with MDI scores. Significance was determined at a p < 0.05. Results: We found that BAEP values were inversely associated with MDI scores in premature infants (β = −1.89; 95% confidence interval = −3.42 to −0.36), and that the effect of gestational age and BAEP values on the MDI scores is decreased by 1.89 points due to the interaction between these two variables. In premature babies, the lower the BAEP value below the mean, the greater the decrease in MDI score at age 2 years. Asphyxia and lower socioeconomic status in the family were also covariates associated with lower MDI scores at age 2 years. Conclusion: The data provided evidence that BAEP values outside the normal range in premature infants at age 6 months may predict developmental delays in cognitive and motor skills, as shown by MDI scores. We propose that BAEP assessment may be utilized as a potential indicator for neurodevelopment, and suggest that early intellectual Wang et al. Predicting Pediatric Neurodevelopment Using BAEP and public health interventions should be encouraged to enrich neurodevelopment in premature babies with BAEP values outside the normal range.

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“…Perinatal hypoxemia has also been shown to damage the neonatal auditory system, including the cochlea and auditory pathways in the brain , which then leads to hearing deficits [30]. Children suffering from perinatal asphyxia tend to exhibit hearing loss with residual neurodevelopmental deficits when compared to those not exposed to asphyxia [31,32]. Previous studies showed that perinatal asphyxia often produces discrete lesions in the generators of brainstem auditory-evoked response central components, the cochlear nuclei, superior olive, and inferior colliculus, and that brainstem auditory-evoked response abnormalities occurred more frequently in those after severe, prolonged asphyxia [30,33].…”

Section: Discussionmentioning

confidence: 99%

Prediction of delayed neuro-psychomotor development in infants using brainstem auditory evoked potentials and the Bayley II scales

Wang¹,

Carroll

Wang³

et al. 2019

Preprint

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Background: Delayed neuro-psychomotor development in infants tends to be present more often as a result of perinatal issues such as asphyxia, respiratory failure, and prematurity. Brainstem auditory evoked potentials (BAEP) provide an objective analysis of central nervous system function and development in infants. This study proposed to assess the neuro-psychomotor development in infants affected by perinatal conditions by comparing the results of their BAEP with assessments of development including mental development indices (MDI), a form of Bayley Scales of Infant Development. Methods: The retrospectively selected population included preterm (28-36 weeks gestation; 95 cases) and term infants (≥ 37 weeks gestation; 100 cases) who were born with specific perinatal conditions. The BAEP were recorded in these infants from 1 to 8 months of age, and the MDI were performed in these infants at age 2 years. Chi-square, ANOVA, and student t-tests were used to test significance of BAEP correlations with MDI indices in theses infants. Significance was determined at a p-value ≤ 0.05. Results: In premature infants (28-32 weeks gestation), 75% had abnormal BAEP, and MDI at age 2 years were moderately low (90.76 ± 4.1); fewer term infants had abnormal BAEP (24.5%), and MDI at age 2 years were moderately higher (98.55 ± 4.6). Preterm infants with abnormal BAEP, and perinatal asphyxia or respiratory failure had low MDI at age 2 years (76.36 ± 3.66 or 80.36 ± 7.66, respectively); 60% fewer term infants with these perinatal conditions had abnormal BAEP, and their MDI were 3-10% higher. Our results show that infants experiencing prematurity, perinatal asphyxia or respiratory failure, may have lower scores of neuro-psychomotor development at age 2, if earlier tests reveal abnormal BAEP assessments in these infants. Conclusion: Our study found that premature infants exposed at birth to conditions such as asphyxia and respiratory failure, and exhibiting abnormal BAEP in their first year, may be predicted to present with delayed neuro-psychomotor development. We propose that BAEP may be utilized as a potential indicator for neuro-psychomotor development, and suggest that parental education and early intellectual interventions to enrich cognition development in children with abnormal BAEP should be encouraged.

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Development of the brainstem auditory pathway in low birthweight and perinatally asphyxiated children with neurological sequelae

Cited by 13 publications

References 27 publications

Avaliação do comportamento auditivo e neuropsicomotor em lactentes de baixo peso ao nascimento

Avaliação do comportamento auditivo e neuropsicomotor em lactentes de baixo peso ao nascimento

Prediction of Delayed Neurodevelopment in Infants Using Brainstem Auditory Evoked Potentials and the Bayley II Scales

Prediction of delayed neuro-psychomotor development in infants using brainstem auditory evoked potentials and the Bayley II scales

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