Development of the Building Plan of the Heart

Moorman, Antoon F.M.; Soufan, Alexandre T.; Hagoort, Jaco; Boer, Piet A. J. de; Christoffels, Vincent M.

doi:10.1196/annals.1302.014

Cited by 35 publications

(27 citation statements)

References 47 publications

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“…The concept has survived until recent times (Srivastava and Olson, 2000) but the enormous advance of our knowledge on how heart develops has changed this vision of heart morphogenesis along the last 5 years (Moorman and Christoffels, 2003;Christoffels et al, 2004;Moorman et al, 2004). It is now accepted that the straight heart tube only contains the outlines of the left ventricle and part of the atrioventricular (AV) region and atrial regions, and therefore the classic precardiac populations (HFs) have been renamed as first or primary heart field (PHFs).…”

Section: Heart Fields and The Making Of A Heartmentioning

confidence: 99%

Building the vertebrate heart - an evolutionary approach to cardiac development

2009

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The vertebrate heart is unique among the blood pumps described in metazoans. In contrast to the myoepithelial tubes found in most animal phyla, the vertebrate heart is made up of multilayered myocardial cells surrounded by connective tissue derived from epicardium and endocardium, and endowed with complex valvular, coronary vessel and conduction systems. Despite these profound differences, a common genetic program seems to underlie the specification and differentiation of all the cardiac tissues. In this article, we will review the similarities in the transcriptional networks and signalling mechanisms regulating cardiac development in different animals, as well as the origin of the main differences existing between vertebrate and invertebrate hearts. We will pay special attention to the hypotheses concerning the evolutionary origin of the endothelium and the epicardium from ancestral blood cells and pronephric progenitors, respectively. We can summarize the transition between the invertebrate and the vertebrate heart as the result of the thickening of the primarily myoepithelial cardiac tube which was concomitant with: 1) an inner lining by an endothelium with the ability to transform into mesenchyme; 2) an outer lining derived from an ancestral pronephric glomerular primordium with vasculogenic potential; 3) a neural crest cell population which reaches the heart from the pharyngeal region; 4) the incorporation of new myocardium at both ends from a second heart field and 5) the formation of specialized chambers. The complex interactions between all these elements originated an exceptionally powerful blood pump which allowed vertebrates to reach their characteristically large size and activity.

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Section: Heart Fields and The Making Of A Heartmentioning

confidence: 99%

Building the vertebrate heart - an evolutionary approach to cardiac development

2009

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“…A functional CCS arises in the tubular heart before specialized components become evident anatomically (Christoffels et al, 2004a;Moorman et al, 2004). Indeed, several transgenic markers highlight regions in the developing heart tube that will form the CCS (reviewed by Myers and Fishman, 2003).…”

Section: Box 3 the Cardiac Conduction Systemmentioning

confidence: 99%

T-box transcription factors and their roles in regulatory hierarchies in the developing heart

2005

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T-box transcription factors are important players in the molecular circuitry that generates lineage diversity and form in the developing embryo. At least seven family members are expressed in the developing mammalian heart,and the human T-box genes TBX1 and TBX5 are mutated in cardiac congenital anomaly syndromes. Here, we review T-box gene function during mammalian heart development in the light of new insights into heart morphogenesis. We see for the first time how hierarchies of transcriptional activation and repression involving multiple T-box factors play out in three-dimensional space to establish the cardiac progenitors fields, to define their subservient lineages, and to generate heart form and function.

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“…[2][3][4] From the classical descriptions of Tawara, 5 we know that the classical description of 2 left fascicles and 1 single right bundle branch has many variations. Endocavitary structures that house distinct branches of the bundles further complicate the potential for both exits and multiple reentry circuits.…”

Section: Variations In the Infra-hisian Conduction Systemmentioning

confidence: 99%