Development of the Composition and Technology of Obtaining a Dental film with Portulaca oleracea extract

Abstract

According to the concept of the World Health Organization (WHO), oral health is the main indicator of the overall level of health and well-being, quality of life. Currently, improving oral health, treatment and prevention of chronic diseases of the mucous membrane are relevant. The creation of new dosage forms is an urgent problem, since existing dosage forms have both advantages and disadvantages. Dental film based on biologically active compounds of plant materials is a promising dosage form. The article presents the results of a study on the selection of ingredients for the rational composition of dental films based on carbon dioxide extract of Portulacaoleracea. Model formulations with various excipients have been developed for the selection of ingredients. In order to select the rational composition, a study was conducted on such characteristics as description, average mass, deviation from average mass, pH value, solubility, and the results of the study were described. The rational composition of the dental film with the conditional name "DentaPort" was established: the active substance is carbon dioxide extract of Portulaca oleracea, the formative substance is sodium alginate, a moisture-saving substance and a plasticizer is glycerin, powdered sugar is a corrigent, purified water is a solvent. The excipients were selected taking into account their compatibility with each other and the extract of Portulacaoleracea.