Development of the olfactory bulb: Evidence for glia-neuron interactions in glomerular formation

Bailey, Mary S.; Puché, Adam C.; Shipley, Michael T.

doi:10.1002/(sici)1096-9861(19991227)415:4<423::aid-cne2>3.0.co;2-g

Cited by 134 publications

(110 citation statements)

References 92 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The olfactory bulb shows evidence of maturation around P4 (Bailey et al 1999). Histological analysis in our study indicated that the olfactory nerve is present within the cribriform foramina as early as P2.…”

Section: Lymphatic Access To Csf: Anatomical Considerations and Questmentioning

confidence: 56%

Development of cerebrospinal fluid absorption sites in the pig and rat: connections between the subarachnoid space and lymphatic vessels in the olfactory turbinates

et al. 2006

View full text Add to dashboard Cite

The textbook view that cerebrospinal fluid (CSF) absorption occurs mainly through the arachnoid granulations and villi is being challenged by quantitative and qualitative studies that support a major role for the lymphatic circulation in CSF transport. There are many potential sites at which lymphatics may gain access to CSF but the primary pathway involves the movement of CSF through the cribriform plate foramina in association with the olfactory nerves. Lymphatics encircle the nerve trunks on the extracranial surface of the cribriform plate and absorb CSF. However, the time during development in which the CSF compartment and extracranial lymphatic vessels connect anatomically is unclear. In this report, CSF-lymphatic connections were investigated using the silastic material Microfil and a soluble Evan's blue-protein complex in two species; one in which significant CSF synthesis by the choroid plexus begins before birth (pigs) and one in which CSF secretion is markedly up regulated within the first weeks after birth (rats). We examined a total of 46 pig fetuses at embryonic (E) day E80-81, E92, E101, E110 (birth at 114 days). In rats, we investigated a total of 115 animals at E21 (birth at 21 days), postnatal (P) day P1-P9, P12, P13, P15, P22, and adults. In pigs, CSF-lymphatic connections were observed in the prenatal period as early as E92. Before this time (E80-81 fetuses) CSF-lymphatic connections did not appear to exist. In rats, these associations were not obvious until about a week after birth. These data suggest that the ability of extracranial lymphatic vessels to absorb CSF develops around the time that significant volumes of CSF are being produced by the choroid plexus and further support an important role for lymphatic vessels in CSF transport.

show abstract

Section: Lymphatic Access To Csf: Anatomical Considerations and Questmentioning

confidence: 56%

Development of cerebrospinal fluid absorption sites in the pig and rat: connections between the subarachnoid space and lymphatic vessels in the olfactory turbinates

et al. 2006

View full text Add to dashboard Cite

show abstract

“…Morphogenesis and wiring of the embryonic olfactory system requires interactions between cells and signals of different origin, including the OP, MgCs, nasal mesenchyme and FB-OB (Lin and Ngai 1999;Bailey et al 1999;St.John et al 2002;Brunjes and Greer 2003;Bashin et al 2003;Nedelec et al 2005). Although the importance of FB in ORN innervation process appears to be modest (Levi et al 2003;Hirata et al 2006), several transcription factor genes, expressed by mature and immature ORN in the OP and OE appear to be essential for guidance and connectivity.…”

Section: Discussionmentioning

confidence: 99%

“…A small number of pioneer axons enter the FB at earlier stages (Astic et al 2002;Key 1998), but their function is still unclear. At later stages (E13.5-E14.5) the basement membrane (BM) separating the MM from the olfactory bulb (OB) is degraded allowing massive entry of ORN axons and the formation of the outer sublaminae of the nerve layer (Doucette 1989;Gong and Shipley 1996;Bailey et al 1999;Au et al 2002).…”

Section: Introductionmentioning

confidence: 99%

The role of Dlx homeogenes in early development of the olfactory pathway

et al. 2007

View full text Add to dashboard Cite

Development of the olfactory pathway requires interaction between cells and signals of different origin. Olfactory receptor neurons (ORN) in the olfactory placodes (OP) extend axons towards the forebrain (FB); with innervation taking place at a later time following degradation of the basement membrane. Cells from the OP migrate along ORN axons and differentiate into various elements, including ensheathing and Gonadotropin Releasing Hormone (GnRH)+ cells. The importance of the olfactory connection and migration is highlighted by the severe endocrine phenotype in Kallmann's patients who lack this migratory pathway. Little is known about the genetic control of intrinsic ORN properties. Inactivation of the distalless-related Dlx5 prevents connections between ORNs and FB. Using a grafting approach we show that misguidance and lack of connectivity is due to intrinsic defects in ORN neurites and migratory cells (MgC), and not to environmental factors. These data point to a cell-autonomous function of Dlx5 in providing ORN axons with their connectivity properties. Dlx5 also marks a population of early MgC that partly overlaps with the GnRH+ population. In the absence of Dlx5 MgCs of the Dlx5+ lineage migrate, associated with PSA-NCAM+ axons, but fail to reach the FB as a consequence of the lack of axonal connection and not an inability to migrate. These data suggests that Dlx5 is not required to initiate migration and differentiation of MgCs.

show abstract

“…CNS central nervous system, PNS peripheral nervous system, GL glomerular layer, OE olfactory bulb, ON olfactory nerve. Scale bars b 300 lm, c-e 75 lm, f-j 35 lm species [8,18,19], it was fortuitous that the human S100ß regulatory sequences used to drive expression of DsRed produced ubiquitous expression in OECs of the NFL. OECs in the iNFL were positive for neuropeptide Y (Fig.…”

Section: Oecs Are a Heterogeneous Population Of Cellsmentioning

confidence: 99%

Lamellipodia mediate the heterogeneity of central olfactory ensheathing cell interactions

Windus

Lineburg

Scott

et al. 2010

Cell. Mol. Life Sci.

109

View full text Add to dashboard Cite

The growth and guidance of primary olfactory axons are partly attributed to the presence of olfactory ensheathing cells (OECs). However, little is understood about the differences between the subpopulations of OECs and what regulates their interactions. We used OEC-axon assays and determined that axons respond differently to peripheral and central OECs. We then further purified OECs from anatomically distinct regions of the olfactory bulb. Cell behaviour assays revealed that OECs from the olfactory bulb were a functionally heterogeneous population with distinct differences which is consistent with their proposed roles in vivo. We found that the heterogeneity was regulated by motile lamellipodial waves along the shaft of the OECs and that inhibition of lamellipodial wave activity via Mek1 abolished the ability of the cells to distinguish between each other. These results demonstrate that OECs from the olfactory bulb are a heterogeneous population that use lamellipodial waves to regulate cell-cell recognition.

show abstract

Development of the olfactory bulb: Evidence for glia-neuron interactions in glomerular formation

Cited by 134 publications

References 92 publications

Development of cerebrospinal fluid absorption sites in the pig and rat: connections between the subarachnoid space and lymphatic vessels in the olfactory turbinates

Development of cerebrospinal fluid absorption sites in the pig and rat: connections between the subarachnoid space and lymphatic vessels in the olfactory turbinates

The role of Dlx homeogenes in early development of the olfactory pathway

Lamellipodia mediate the heterogeneity of central olfactory ensheathing cell interactions

Contact Info

Product

Resources

About