Development of transdermal based hydrogel formulations of vinorelbine with an evaluation of their in vitro profiles and activity against melanoma cells and in silico prediction of drug absorption

Fonseca, Alyne de Melo; Araújo, Cristina da Costa Bernardes; Silva, Julianna Henriques da; Honorio, Thiago da Silva; Nasciutti, Luiz Eurico; Cabral, Lúcio Mendes; Carmo, Flávia Almada do; Sousa, Valéria Pereira de

doi:10.1016/j.jddst.2021.102449

Cited by 9 publications

(6 citation statements)

References 49 publications

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“…It is available in the market as injectable and oral formulations. Few novel formulations, i.e., liposome (Marcucci and María, 2004), transdermal based hydrogel formulations (Fonseca et al, 2021), lipid-based nanoformulation (Cybulska-Stopa et al, 2013;Kanojia et al, 2020). Have also been researched.…”

Section: Vinorelbine Bitartratementioning

confidence: 99%

“…Challenges with administration during mixing of the docetaxel with the diluent and need of targeting necessitated remodeling of the currently available docetaxel formulation but none has made it to clinical setting as an alternative. A recently published review by Karamot and Oyediran summarized virtually all the novel formulations researched on Docetexal (Fonseca et al, 2021).…”

Section: Docetaxelmentioning

confidence: 99%

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A review of FDA approved drugs and their formulations for the treatment of breast cancer

et al. 2023

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Breast cancer is one of the most diagnosed solid cancers globally. Extensive research has been going on for decades to meet the challenges of treating solid tumors with selective compounds. This article aims to summarize the therapeutic agents which are either being used or are currently under approval for use in the treatment or mitigation of breast cancer by the US FDA, to date. A structured search of bibliographic databases for previously published peer-reviewed research papers on registered molecules was explored and data was sorted in terms of various categories of drugs used in first line/adjuvant therapy for different stages of breast cancer. We included more than 300 peer-reviewed papers, including both research and reviews articles, in order to provide readers an useful comprehensive information. A list of 39 drugs are discussed along with their current status, dose protocols, mechanism of action, pharmacokinetics, possible side effects, and marketed formulations. Another interesting aspect of the article included focusing on novel formulations of these drugs which are currently in clinical trials or in the process of approval. This exhaustive review thus shall be a one-stop solution for researchers who are working in the areas of formulation development for these drugs.

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Section: Vinorelbine Bitartratementioning

confidence: 99%

Section: Docetaxelmentioning

confidence: 99%

A review of FDA approved drugs and their formulations for the treatment of breast cancer

et al. 2023

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“…Chitosan hydrogels loaded with drugs could noninvasively deliver specific doses of active substances through the skin barrier, in a continuous or controlled manner, which promote wound healing while significantly increase patient comfort, have much potential biomedical application value . A thermosensitive hydrogel was designed by Fonseca et al (2021) to deliver vinorelbine through the skin for the treatment of melanoma. Viyoch et al (2005) designed a transdermal plaster, based on chitosan and starch, and cross-linked it to produce a hydrogel that produced a stable release of alpha-hydroxy acid.…”

Section: Chitosan Hydrogelsmentioning

confidence: 99%

Hydrogels for the treatment of radiation-induced skin and mucosa damages: An up-to-date overview

Cui

Yang³

et al. 2022

Front. Mater.

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Radiation-induced damages are difficult to heal than normal wounds. This is because radiation therapy could lead to an imbalanced inflammatory response, oxidative stress response, lack of angiogenesis, and a high risk of bacterial infection, which are considered to be the greatest challenges in radiation-induced damages treatment. Hydrogels are semi-occlusive and are composed of complex hydrophilic polymers with a higher water content. Due to their excellent mechanical and biochemical property (such as adhesiveness, antibacterial, and antioxidant abilities), hydrogels represent a promising strategy that has achieved potent therapeutic efficacy in the treatment of radiation-induced skin and mucosa damages. This review systematically and comprehensively summarizes the recent progress of various types of hydrogels such as natural biopolymer, synthetic polymer, composite hydrogels and commodity dressings for the treatment of radiation-induced skin and mucosa damages.

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“…Hydrogels represent extremely versatile biomaterials with wide applications in tissue engineering and drug delivery; they can be used in an injectable form [11] or as transdermal patches [12,13], nanoparticles [14][15][16], etc. They are 3D networked materials and offer the possibility of the local delivery of increased concentrations of anti-tumor drugs, and their release profile can be controlled by the composition and processing conditions [17].…”

Section: Introductionmentioning

confidence: 99%

New Methacrylated Biopolymer-Based Hydrogels as Localized Drug Delivery Systems in Skin Cancer Therapy

Luca

Nacu

Tanasache

et al. 2023

Gels

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The aim of the present work was to obtain drug-loaded hydrogels based on combinations of dextran, chitosan/gelatin/xanthan, and poly (acrylamide) as a sustained and controlled release vehicle of Doxorubicin, a drug used in skin cancer therapy that is associated with severe side effects. Hydrogels for use as 3D hydrophilic networks with good manipulation characteristics were produced using methacrylated biopolymer derivatives and the methacrylate group’s polymerization with synthetic monomers in the presence of a photo-initiator, under UV light stimulation (365 nm). Transformed infrared spectroscopy analysis (FT-IR) confirmed the hydrogels’ network structure (natural–synthetic composition and photocrosslinking), while scanning electron microscopy (SEM) analysis confirmed the microporous morphology. The hydrogels are swellable in simulated biological fluids and the material’s morphology regulates the swelling properties: the maximum swelling degree was obtained for dextran–chitosan-based hydrogels because of their higher porosity and pore distribution. The hydrogels are bioadhesive on a biological simulating membrane, and values for the force of detachment and work of adhesion are recommended for applications on skin tissue. The Doxorubicin was loaded into the hydrogels and the drug was released by diffusion for all the resulting hydrogels, with small contributions from the hydrogel networks’ relaxation. Doxorubicin-loaded hydrogels are efficient on keratinocytes tumor cells, the sustained released drug interrupting the cells’ division and inducing cell apoptosis; we recommend the obtained materials for the topical treatment of cutaneous squamous cell carcinoma.

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Development of transdermal based hydrogel formulations of vinorelbine with an evaluation of their in vitro profiles and activity against melanoma cells and in silico prediction of drug absorption

Cited by 9 publications

References 49 publications

A review of FDA approved drugs and their formulations for the treatment of breast cancer

A review of FDA approved drugs and their formulations for the treatment of breast cancer

Hydrogels for the treatment of radiation-induced skin and mucosa damages: An up-to-date overview

New Methacrylated Biopolymer-Based Hydrogels as Localized Drug Delivery Systems in Skin Cancer Therapy

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