Development of voltammetric sensor based on polyimide-MWCNT composite membrane for rapid and highly sensitive detection of paracetamol

Burç, Muammer; Köytepe, Süleyman; Duran, Serap Titretir; Ayhan, Nurcan; Aksoy, Büşra; Seçki̇n, Turgay

doi:10.1016/j.measurement.2019.107103

Cited by 42 publications

(8 citation statements)

References 32 publications

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“…Therefore this supporting electrolyte (H 2 SO 4 0.25 M + KCl 0,25 M) was chosen for further analysis. Indeed, the presence of KCl salt improved the response of the sensor as indicated elsewhere [17]. The effect of pH on the diclofenac oxidation at (G-MWCNT)-CPE 3 electrode was carried out by voltammetric method in the pH range of 0.5-4.0 and for different concentrations of diclofenac (0.4, 0.7 and 1 10 À 6 mol L À 1 ) in aqueous solution, containing H 2 SO 4 0.25 M + KCl 0,25 M. Three concentrations have been used in order to compare the sensitivity of the linear variation of Ip.…”

Section: Effect Of Phsupporting

confidence: 63%

Preconcentration and Successful Selective Detection of Traces of Diclofenac in Water using a Nanostructured Modified Carbon Paste Electrode

et al. 2020

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A highly sensitive, simple and low cost sensor for the quantification of the diclofenac has been constructed. This sensor consists of a carbon paste nano‐structured by Multi‐Walled Carbon Nanotubes (G‐MWCNT)‐CPE. Scanning electron microscopy (SEM) and voltammetry technique were used to characterize the electrode material and to determine the analytical performances of the sensor in comparison with those obtained at a G‐CPE. The electrochemical oxidation of diclofenac on both G‐CPE and (G‐MWCNT)‐CPE electrodes is mainly controlled by adsorption, presenting a maximum peak current intensity in H2SO4 0.5 mol L−1. The carbon nanotubes, as well as they provide higher conductivity of the paste, act as spacers between the flake graphite particles and avoid their stacking in order to make the surface of graphite particles more accessible to DCF adsorption. The voltammetric measurements of diclofenac on (G‐MWCNT)‐CPE provide a large quantification range from 0.02 to 1 μmol L−1, a detection limit of 0.004 μmol L−1 and quantification limit of 0.014 μmol L−1 under the optimized operating conditions (H2SO4, 0.25 M+KCl 0.25 M, scan rate of 30 mV s−1, preconcentration time 18 min. and MWNTC% (30 %)). The (G‐MWCNT)‐CPE sensor was successfully applied to natural water samples, just acidified with sulfuric acid (pH<1). These samples were doped with diclofenac in sub‐micromolar range and the developed method was validated with excellent recoveries (within a maximum of 3 % difference from 100 %) for all samples indicating no interference effects of the water matrix.

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Section: Effect Of Phsupporting

confidence: 63%

Preconcentration and Successful Selective Detection of Traces of Diclofenac in Water using a Nanostructured Modified Carbon Paste Electrode

et al. 2020

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“…These polymers are known for their high temperature performance, in the 200–300 °C range, as well as chemical resistance [ 35 ]. They are employed to replace the conventional use of glass, metals, and, even, steel in a broad range of industrial applications, including membrane materials for separation [ 36 ], high temperature plastics, adhesives, dielectrics, photoresists, sensors, high temperature fuel cells, flat panel displays, aerospace applications, and chemical/petrochemical industries [ 37 ].…”

Section: Introductionmentioning

confidence: 99%

A Study of the Reinforcement Effect of MWCNTs onto Polyimide Flat Sheet Membranes

et al. 2020

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Polyimides rank among the most heat-resistant polymers and find application in a variety of fields, including transportation, electronics, and membrane technology. The aim of this work is to study the structural, thermal, mechanical, and gas permeation properties of polyimide based nanocomposite membranes in flat sheet configuration. For this purpose, numerous advanced techniques such as atomic force microscopy (AFM), SEM, TEM, TGA, FT-IR, tensile strength, elongation test, and gas permeability measurements were carried out. In particular, BTDA–TDI/MDI (Ρ84) co-polyimide was used as the matrix of the studied membranes, whereas multi-wall carbon nanotubes were employed as filler material at concentrations of up to 5 wt.% All studied films were prepared by the dry-cast process resulting in non-porous films of about 30–50 μm of thickness. An optimum filler concentration of 2 wt.% was estimated. At this concentration, both thermal and mechanical properties of the prepared membranes were improved, and the highest gas permeability values were also obtained. Finally, gas permeability experiments were carried out at 25, 50, and 100 °C with seven different pure gases. The results revealed that the uniform carbon nanotubes dispersion lead to enhanced gas permeation properties.

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“…Finally, the interaction between PSA and thiolated aptamer led to a noticeable rise in the amount of the Rct to 3976 Ω, indicating that the fabricated aptasensor interacted successfully with PSA ( Figure 5, curve e). PSA determination with the aptasensor Due to the higher sensitivity of the DPV technique compared to CV, determination by DPV technique is recommended; besides, DPV can lower the background current (41). The quantitative determination of PSA was achieved by DPV signals in the same solution used for CV and under the optimal experimental conditions (potential range of + 0.7 to -0.4 V interval time = 0.2 s, modulation amplitude = 0.05 V).…”

Section: Optimization Of the Analytical Parameters For Psa Determinationmentioning

confidence: 99%

A Sensitive Aptamer-Based Biosensor for Electrochemical Quantification of PSA as a Specific Diagnostic Marker of Prostate Cancer

et al. 2020

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Purpose: The current project aimed to design a simple, highly sensitive, and economical label-free electrochemical aptasensor for determination of prostate-specific antigen (PSA), as the gold standard biomarker for prostate cancer diagnosis. The aptasensor was set up using a screen-printed carbon electrode (SPCE) modified by gold nanoparticles (Au NPs) conjugated to thiolated aptamers. Methods: Cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) were implemented for electrochemical (EC) characterization of the aptasensor. The determination of PSA was also performed through differential pulse voltammetry (DPV) in [Fe (CN) 6]3-/4- electrolyte solution. Results: The present aptasensor was shown an outstanding linear response in the concentration range of 1 pg/mL - 200 ng/mL with a remarkably lower limit of detection of 0.077 pg/mL. The optimum concentration for PSA separation and the optimum incubation time for antigen-aptamer binding were determined by observing and electing the highest electrochemical responses in a specified time or concentration. Conclusion: According to the results of the specificity tests, the designed aptasensor did not show any significant interactions with other analytes in real samples. Clinical functionality of the aptasensor was appraised in serum samples of healthy individuals and patients examining the PSA level through the fabricated aptasensor and the reference methods. Both methods are comparable in sensitivity. The present fabricated PSA aptasensor with substantial characteristics of ultra-sensitivity and cost-effectiveness can be conventionally built and used for the routine check-up of the men for prostate problems.

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Development of voltammetric sensor based on polyimide-MWCNT composite membrane for rapid and highly sensitive detection of paracetamol

Cited by 42 publications

References 32 publications

Preconcentration and Successful Selective Detection of Traces of Diclofenac in Water using a Nanostructured Modified Carbon Paste Electrode

Preconcentration and Successful Selective Detection of Traces of Diclofenac in Water using a Nanostructured Modified Carbon Paste Electrode

A Study of the Reinforcement Effect of MWCNTs onto Polyimide Flat Sheet Membranes

A Sensitive Aptamer-Based Biosensor for Electrochemical Quantification of PSA as a Specific Diagnostic Marker of Prostate Cancer

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