Developmental changes of the activity of monoamine oxidase in pre- and postnatally lead exposed rats

Shin, Chan Young; Choi, Ji Woong; Choi, Min Sik; Ryu, Jae Ryun; Ko, Kwang Ho; Cheong, Jae Hoon

doi:10.1016/j.etap.2006.12.001

Cited by 7 publications

(5 citation statements)

References 24 publications

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“…In this study, we observed the normal range of the mean concentrations of neurotransmitter MAO levels (<650 U/L) in the exposed and nonexposed groups (exposed group vs. non-exposed group: 362.060±97.981 vs. 369.771±86.752). Moreover, Comparisons of neurotransmitter MAO concentrations between the exposed and non-exposed groups were not significantly different, consistent with the study by Shin et al [61].…”

Section: The Comparison Of Concentrations Of Pb CD and Ni In The Bloo...supporting

confidence: 91%

Comparison of monoamine oxidase and selected heavy metal levels in the blood and the workplace among e-waste sorting workers in Ubon Ratchathani Province, Thailand

Harasarn

Phatrabuddha

Kaewkaen

et al. 2022

Rocz Panstw Zakl Hig

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Background. E-waste sorting workers usually separate electronic waste. Therefore, they can be exposed to heavy metals. Objectives. This study compared monoamine oxidase (MAO) levels affected by the levels of lead (Pb), cadmium (Cd), and nickel (Ni) in the blood and their workplace among e-waste sorting workers (EWSW). Material and methods. The exposed group included 76 EWSW, and the non-exposed group included 49 village health volunteers. An interview form was used to assess the risk factors. We measured Pb, Cd, and Ni on the work surfaces and in the blood, and MAO levels as a neurological enzymes. Results. Among the EWSW, 42 were males (55.3%), and the mean age (SD) 48.0 (12.64) years, and income were 156.37 ± 88.08 USD. In the work areas of the exposed group, the concentration of Pb, Cd, and Ni were 245.042 (± 613.910), 0.375 (± 0.662), and 46.115 (± 75.740) μg/100 cm2, respectively, while the non-exposed group, the concentration of Pb, Cd, and Ni were 0.609 (± 0.934), 0.167 (± 1.171) and 1.020 (± 0.142) μg/100 cm2. Pb and Ni concentrations in the workplace of the exposed groups were statistically different from that of the non-exposed group. Pb, Cd, and Ni concentrations in serum were 6.411 ± 1.492 μg/dL, 0.9480 ± 0.350 μg/L, 2.568 ± 0.468 μg/L, respectively, while in the non-exposed group, the heavy metal concentrations were 6.411 ± 1.620 μg/dL, 0.909 ± 0.277 μg/L, 2.527 ± 0.457 μg/L. The MAO in the exposed group was 362.060 ± 97.981 U/L, while that in the non-exposed group was 369.771 ± 86.752 U/L. Moreover, MAO concentration was significantly different from Ni concentration (p < 0.05). Conclusion. The electronic waste sorting workers should clean their work areas to reduce the Pb, Cd, and Ni levels on the working surfaces, and health surveillance should be performed.

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Section: The Comparison Of Concentrations Of Pb CD and Ni In The Bloo...supporting

confidence: 91%

Comparison of monoamine oxidase and selected heavy metal levels in the blood and the workplace among e-waste sorting workers in Ubon Ratchathani Province, Thailand

Harasarn

Phatrabuddha

Kaewkaen

et al. 2022

Rocz Panstw Zakl Hig

View full text Add to dashboard Cite

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Section: Discussionmentioning

confidence: 99%

“…MAO is an intracellular flavin-containing enzyme that catalyzes the oxidative deamination of monoamine neurotransmitters like norepinephrine and epinephrine in the brain and peripheral tissues 50 . MAO is localized on the outer membrane of mitochondria regulating the extracellular concentration of monoamines 50 . In addition, AChE is the key enzyme in the nervous system responsible for the degradation of acetylcholine "an important neurotansmitor" during neurotransmission, which is necessary for learning and memory 51 .…”

Section: Discussionmentioning

confidence: 99%

Synergistic protective effect of Beta vulgaris with meso-2,3-dimercaptosuccinic acid against lead-induced neurotoxicity in male rats

Shaban

El-Kader

Mogahed

et al. 2021

Sci Rep

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Lead (Pb) toxicity is one of the most prevalent causes of human neurotoxicity. The available chelator drugs used now have many adverse effects. So, in this study, the protective role of Betavulgaris juice (BVJ) on rat neurotoxicity induced by Pb was evaluated and the results were compared with the results of dimercaptosuccinic acid (DMSA, as used drug). Additionally, the synergistic effect of BVJ and DMSA against Pb-induced neurotoxicity was assessed. The study focused on the determination of the antioxidant, anti-inflammatory, and neurological potential of BVJ (alone, and with DMSA) towards lead-induced neurotoxicity. Also, the characterization of BVJ was studied. The results showed that BVJ contains considerable quantities of polyphenols, triterpenoids, and betalains which play an important role as antioxidants and anti-inflammatory. BVJ exhibited a protective effect against neurotoxicity via the reduction of Pb levels in blood and brain. Moreover, BVJ decreased the oxidative stress, inflammation, and cell death induced by Pb. Also, BVJ regulated the activities of acetylcholine esterase and monoamine oxidase-A which changed by Pb toxicity. BVJ and DMSA combination displayed a synergistic antineurotoxic effect (combination index ˂ 1). These results were in harmony with brain histopathology. Conclusion: BVJ has a powerful efficacy in the protection from brain toxicity via diminishing Pb in the brain and blood circulation, resulting in the prevention of the oxidative and inflammatory stress. Treatment with BVJ in combination with DMSA revealed a synergistic effect in the reduction of neurotoxicity induced by Pb. Also, the antioxidant and anti-inflammatory effects of the BVJ lead to the improvement of DMSA therapy.

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“…Research findings also suggest that gestation through lactation is a sensitive period for exposure to low levels of Pb leading to life long cognitive deficits (Basha and Reddy, 2010; Ryzhavskii et al, 2008; Tang et al, 2009) because the brain undergoes intense development during this period (Bayer et al, 1993). Lead poisoning can affect multiple target systems in brain, but several researchers including us have focused on the catecholaminergic (Prasanthi et al, 2010; Shin et al, 2007; Devi et al, 2005; Flora et al, 1999) and cholinergic system (Reddy et al, 2007, 2003). Since these neurotransmitters are believed to regulate motor coordination and emotion, in this study, we investigated the effects of perinatal Pb‐exposure on the neurochemical and behavioral perturbations in rats.…”

Section: Introductionmentioning

confidence: 99%

Perinatal lead exposure alters postnatal cholinergic and aminergic system in rat brain: reversal effect of calcium co‐administration

Basha

Rani²,

Devi³

et al. 2012

Intl J of Devlp Neuroscience

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Our earlier studies indicated the role of neurotransmitter systems in lead (Pb) induced behavioral perturbations. In this study, we examined the alterations in synaptosomal acetylcholine (ACh), epinephrine, dopamine, acetylcholinesterase (AChE), and mitochondrial monoamine oxidase (MAO) in the cerebellum and hippocampus of perinatally Pb-exposed rats. Rats (Wistar) were exposed to 0.2% Pb (Pb acetate in drinking water of mother) from gestational day 6 and the pups were exposed lactationally (through mother's milk) to Pb till weaning (postnatal day 21). Studies conducted on different postnatal days (PND 21, 28, 35 and 60) showed significant decreases in synaptosomal AChE and mitochondrial MAO activities, and increases in the levels of ACh, dopamine and epinephrine in the cerebellum and hippocampus of Pb-exposed rats. These alterations were greater at PND 35 and more pronounced in the cholinergic system (ACh and AChE) of hippocampus and the aminergic system (epinephrine, dopamine and MAO) of cerebellum. The total locomotor activity and exploratory behavior were also decreased significantly in Pb-exposed animals corresponding to the alterations observed in cholinergic and aminergic systems. Calcium administration together with Pb, however significantly reversed the Pb-induced alterations in transmitters and enzymes, as well as exploratory and motor behavior suggesting protective effect of calcium in Pb-exposed animals.

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Developmental changes of the activity of monoamine oxidase in pre- and postnatally lead exposed rats

Cited by 7 publications

References 24 publications

Comparison of monoamine oxidase and selected heavy metal levels in the blood and the workplace among e-waste sorting workers in Ubon Ratchathani Province, Thailand

Comparison of monoamine oxidase and selected heavy metal levels in the blood and the workplace among e-waste sorting workers in Ubon Ratchathani Province, Thailand

Synergistic protective effect of Beta vulgaris with meso-2,3-dimercaptosuccinic acid against lead-induced neurotoxicity in male rats

Perinatal lead exposure alters postnatal cholinergic and aminergic system in rat brain: reversal effect of calcium co‐administration

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