Developmental exposure to bisphenol A (BPA) alters sexual differentiation in painted turtles (Chrysemys picta)

Jandegian, Caitlin M.; Deem, Sharon L.; Bhandari, Ramji Kumar; Holliday, Casey; Nicks, Diane; Rosenfeld, Cheryl S.; Selcer, Kyle W.; Tillitt, Donald E.; Saal, Frederick S. vom; Vélez-Rivera, Vanessa; Yang, Ying; Holliday, Dawn K.

doi:10.1016/j.ygcen.2015.04.003

Cited by 52 publications

(21 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Painted turtles ( Chrysemys picta ) also lack sex chromosomes and demonstrate TSD. When we exposed painted turtles eggs that were incubated at the male producing temperature (MPT) to the endocrine disrupting chemical, bisphenol A (BPA), it resulted in partial gonadal sex reversal to female, feminized their behavioral responses, and altered brain gene expression patterns, especially for transcripts associated with mitochondrial and ribosomal function relative to control males (Jandegian et al, 2015 ; Manshack et al, 2016 , 2017 ).…”

Section: Brain Sexual Differentiation In Example Fish and Reptilian Smentioning

confidence: 99%

Brain Sexual Differentiation and Requirement of SRY: Why or Why Not?

Rosenfeld

2017

Front. Neurosci.

Self Cite

View full text Add to dashboard Cite

Brain sexual differentiation is orchestrated by precise coordination of sex steroid hormones. In some species, programming of select male brain regions is dependent upon aromatization of testosterone to estrogen. In mammals, these hormones surge during the organizational and activational periods that occur during perinatal development and adulthood, respectively. In various fish and reptiles, incubation temperature during a critical embryonic period results in male or female sexual differentiation, but this can be overridden in males by early exposure to estrogenic chemicals. Testes development in mammals requires a Y chromosome and testis determining gene SRY (in humans)/Sry (all other therian mammals), although there are notable exceptions. Two species of spiny rats: Amami spiny rat (Tokudaia osimensis) and Tokunoshima spiny rat (Tokudaia tokunoshimensis) and two species of mole voles (Ellobius lutescens and Ellobius tancrei), lack a Y chromosome/Sry and possess an XO chromosome system in both sexes. Such rodent species, prototherians (monotremes, who also lack Sry), and fish and reptile species that demonstrate temperature sex determination (TSD) seemingly call into question the requirement of Sry for brain sexual differentiation. This review will consider brain regions expressing SRY/Sry in humans and rodents, respectively, and potential roles of SRY/Sry in the brain will be discussed. The evidence from various taxa disputing the requirement of Sry for brain sexual differentiation in mammals (therians and prototherians) and certain fish and reptilian species will be examined. A comparative approach to address this question may elucidate other genes, pathways, and epigenetic modifications stimulating brain sexual differentiation in vertebrate species, including humans.

show abstract

Section: Brain Sexual Differentiation In Example Fish and Reptilian Smentioning

confidence: 99%

Brain Sexual Differentiation and Requirement of SRY: Why or Why Not?

Rosenfeld

2017

Front. Neurosci.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Bisphenol A (2, 2‐bis[4 hydroxyphenyl] propane) is one such environmental toxicant which is a synthetic plastic monomer and plasticiser, considered as one of the highest volume chemicals produced worldwide, with the global annual output of 6.8 million tons (Jandegian et al., ). The production and consumption of BPA are progressively increasing worldwide due to its extensive use in industry and commerce in the production of daily necessities such as baby feeding bottles, food packaging, thermal paper, electronic equipment and medical facilities (Huang et al., ; Vandenberg, Maffini, Sonnenschein, Rubin, & Soto, ).…”

Section: Introductionmentioning

confidence: 99%

Bisphenol A induced oxidative stress and apoptosis in mice testes: Modulation by selenium

2017

View full text Add to dashboard Cite

Spermatogenesis, a highly coordinated process, is prone to environmental insults which may lead to impaired spermatogenesis or, at worst, infertility. Bisphenol A (BPA) is a well-known global environmental toxicant and a ubiquitous oestrogenic chemical. This study evaluated the role of selenium (0.5 ppm sodium selenite/kg diet) on spermatogenesis after BPA treatment in different groups of male BALB/c mice: control, selenium, BPA and selenium+BPA. Markers of oxidative stress and apoptosis were evaluated in testis after BPA treatment. Significant decrease in sperm concentration and motility and increased reactive oxygen species(ROS) and LPO levels were seen in BPA group. Histopathological changes revealed extensive vacuolisation, lumen devoid of spermatozoa and decreased germ cell count, confirmed by testicular germ cell count studies. TUNEL assay for apoptosis showed increased number of TUNEL-positive germ cells in BPA group with increased percentage apoptotic index. However, in Se+BPA group, histopathological studies revealed systematic array of all germ cells, preserved basement membrane with relatively less vacuolisation, improved sperm parameters and ROS and LPO levels and decreased number of TUNEL-positive germ cells. These results clearly demonstrate the role of selenium in ameliorating oxidative stress and apoptosis induced upon BPA treatment in mice and can be further used as therapeutic target in male infertility.

show abstract

“…The MPH field placement students have researched the impacts of endocrine disruptor chemicals on human and wildlife health, and EID among camels in Kenya, as two examples. A number of these students have contributed to the growing body of One Health literature by publishing their work [12], [33], [34]. Through these projects, public health students have gained a better understanding of the conservation challenges that threaten human health and, more importantly, the actions that may be taken to help both human public health and wildlife and wild land conservation.…”

mentioning

confidence: 99%

Zoos and public health: A partnership on the One Health frontier

et al. 2017

View full text Add to dashboard Cite

Today, accredited zoos are not just places for entertainment, they are actively involved in research for conservation and health. During recent decades in which the challenges for biodiversity conservation and public health have escalated, zoos have made significant changes to address these difficulties. Zoos increasingly have four key areas of focus: education, recreation, conservation, and research. These key areas are important in addressing an interrelated global conservation (i.e. habitat and wildlife loss) and public health crisis. Zoo and public health professionals working together within a One Health framework represent a powerful alliance to address current and future conservation and public health problems around the world. For researchers, practitioners, and students, the collaboration between zoos and public health institutions offers the opportunity to both teach and operationalize this transdisciplinary approach. Using examples from our programs, we give a template for moving forward with collaborative initiatives and sustainable solutions involving partners in both zoos and public health institutions. We provide examples of cooperative programs and suggest a model for consideration in the development of further activities in this area.

show abstract

Developmental exposure to bisphenol A (BPA) alters sexual differentiation in painted turtles (Chrysemys picta)

Cited by 52 publications

References 43 publications

Brain Sexual Differentiation and Requirement of SRY: Why or Why Not?

Brain Sexual Differentiation and Requirement of SRY: Why or Why Not?

Bisphenol A induced oxidative stress and apoptosis in mice testes: Modulation by selenium

Zoos and public health: A partnership on the One Health frontier

Contact Info

Product

Resources

About