Developmental exposure to polychlorinated biphenyls (PCBs) in the maternal diet causes host-microbe defects in weanling offspring mice

Rude, Kavi M.; Pusceddu, Matteo M.; Keogh, Ciara E.; Sladek, Jessica A.; Rabasa, Gonzalo; Miller, Elaine N.; Sethi, Sunjay; Keil, Kimberly P.; Pessah, Isaac N.; Lein, Pamela J.; Gareau, Mélanie G.

doi:10.1016/j.envpol.2019.07.066

Cited by 53 publications

(32 citation statements)

References 81 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have shown that the gut microbiota could affect the brain-gut axis and contribute to the pathogenesis of neurological diseases including Parkinson's, epilepsy, autism spectrum disorders, and tic disorders (Zhao et al, 2017;Kovács et al, 2019;Rude et al, 2019). Early intestinal flora establishment can affect nervous system development, resulting in anxiety behaviors and other mental health problems after maturity, and treatment of pregnant female rats with lowdose antibiotics has been shown to lead to an imbalance of intestinal flora, with subsequent alterations in the behavior of offspring (Borre et al, 2014;Leclercq et al, 2017;Zhao et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…Gut microbiota alterations may be associated with neurological conditions including Alzheimer's disease, epilepsy, and autism (Fan et al, 2019;Rude et al, 2019). Many researchers have proposed the existence of bidirectional regulation of the brain-gut axis, which involves gut microbiota metabolites that affect neurotransmitter levels, thereby influencing brain function (Melli et al, 2016;Khalil et al, 2019;Lacorte et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Case-Control Study of the Effects of Gut Microbiota Composition on Neurotransmitter Metabolic Pathways in Children With Attention Deficit Hyperactivity Disorder

et al. 2020

View full text Add to dashboard Cite

Background: Attention-deficit/hyperactivity disorder (ADHD) is a neuropsychiatric condition that may be related to an imbalance of neural transmitters. The gut microbiota is the largest ecosystem in the human body, and the brain-gut axis theory proposes that the gut microbiome can affect brain function in multiple ways. The purpose of this study was to explore the gut microbiota in children with ADHD and assess the possible role of the gut microbiota in disease pathogenesis to open new avenues for ADHD treatment.Methods: A case-control design was used. We enrolled 17 children aged 6-12 years with ADHD who were treated in the Pediatric Outpatient Department of the First Medical Center of the Chinese PLA General Hospital from January to June, 2019. Seventeen children aged 6-12 years were selected as the healthy control (HC) group. Fecal samples of cases and controls were analyzed by shotgun metagenomics sequencing. Alpha diversity and the differences in the relative abundances of bacteria were compared between the two groups. Functional annotations were performed for the microbiota genes and metabolic pathways were analyzed using the Kyoto Encyclopedia of Genes and Genomes (KEGG). Results:There was no significant difference in the alpha diversity of gut microbiota between the ADHD and HC groups. Compared with HCs, Faecalibacterium and Veillonellaceae were significantly reduced in children with ADHD (P < 0.05), Odoribacter and Enterococcus were significantly increased [linear discriminant analysis (LDA) > 2]. At the species level, Faecalibacterium prausnitzii, Lachnospiraceae bacterium, and Ruminococcus gnavus were significantly reduced in the ADHD group (P < 0.05), while Bacteroides caccae, Odoribacter splanchnicus, Paraprevotella xylaniphila, and Veillonella parvula were increased (P < 0.05). Metabolic pathway analysis revealed significant between-group differences in the metabolic pathways of neurotransmitters (e.g., serotonin and dopamine) (P < 0.05). Frontiers in Neuroscience | www.frontiersin.org 1 February 2020 | Volume 14 | Article 127 Wan et al. Gut Microbiota Role in ADHDConclusion: Composition differences of gut microbiota in subjects with ADHD may contribute to brain-gut axis alterations and affect neurotransmitter levels, which could contribute to ADHD symptoms.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Case-Control Study of the Effects of Gut Microbiota Composition on Neurotransmitter Metabolic Pathways in Children With Attention Deficit Hyperactivity Disorder

et al. 2020

View full text Add to dashboard Cite

show abstract

“…PCBs caused a state of dysbiosis, increased inflammatory state, and a more permeable gastrointestinal barrier in the offspring especially in the group with genetic mutations. The latter group also was more predisposed to develop defects in neurobehavioral development (Rude et al, 2019).…”

Section: Environmental Chemicals and Pollutantsmentioning

confidence: 98%

“…Polychlorinated biphenyls (PCBs), albeit banned in 1977 for their toxic effects, are still present in the environment (Centers for Disease Control and Prevention (CDC), 2009). Exposure to PCBs is mainly through ingestion and may lead to impairment in the neurological functions and behavior especially in children (Rude et al, 2019). In an animal study, two groups of mice were exposed to PCBs, a wild type group and another with a mutation in RyR1 and FMR1 genes.…”

Section: Environmental Chemicals and Pollutantsmentioning

confidence: 99%

Toxicomicrobiomics: The Human Microbiome vs. Pharmaceutical, Dietary, and Environmental Xenobiotics

et al. 2020

View full text Add to dashboard Cite

The harmful impact of xenobiotics on the environment and human health is being more widely recognized; yet, inter-and intraindividual genetic variations among humans modulate the extent of harm, mostly through modulating the outcome of xenobiotic metabolism and detoxification. As the Human Genome Project revealed that host genetic, epigenetic, and regulatory variations could not sufficiently explain the complexity of interindividual variability in xenobiotics metabolism, its sequel, the Human Microbiome Project, is investigating how this variability may be influenced by human-associated microbial communities. Xenobioticmicrobiome relationships are mutual and dynamic. Not only does the human microbiome have a direct metabolizing potential on xenobiotics, but it can also influence the expression of the host metabolizing genes and the activity of host enzymes. On the other hand, xenobiotics may alter the microbiome composition, leading to a state of dysbiosis, which is linked to multiple diseases and adverse health outcomes, including increased toxicity of some xenobiotics. Toxicomicrobiomics studies these mutual influences between the everchanging microbiome cloud and xenobiotics of various origins, with emphasis on their fate and toxicity, as well the various classes of microbial xenobiotic-modifying enzymes. This review article discusses classic and recent findings in toxicomicrobiomics, with examples of interactions between gut, skin, urogenital, and oral microbiomes with pharmaceutical, foodderived, and environmental xenobiotics. The current state and future prospects of toxicomicrobiomic research are discussed, and the tools and strategies for performing such studies are thoroughly and critically compared.

show abstract

“…Other studies have also reported the impact of exposure to PCB on amphibian [54] and zebrafish microbiomes [50]. Recently, Rude et al (2019) [56] reported that developmental exposure to PCBs induces dysbiosis and epithelial permeability defects in the ileum and colon that result in changes to the microbial β-diversity of juvenile mice.…”

Section: Polychlorinated Biphenylsmentioning

confidence: 99%

Endocrine Disruptors in Food: Impact on Gut Microbiota and Metabolic Diseases

et al. 2020

View full text Add to dashboard Cite

Endocrine disruptors (EDCs) have been associated with the increased incidence of metabolic disorders. In this work, we conducted a systematic review of the literature in order to identify the current knowledge of the interactions between EDCs in food, the gut microbiota, and metabolic disorders in order to shed light on this complex triad. Exposure to EDCs induces a series of changes including microbial dysbiosis and the induction of xenobiotic pathways and associated genes, enzymes, and metabolites involved in EDC metabolism. The products and by-products released following the microbial metabolism of EDCs can be taken up by the host; therefore, changes in the composition of the microbiota and in the production of microbial metabolites could have a major impact on host metabolism and the development of diseases. The remediation of EDC-induced changes in the gut microbiota might represent an alternative course for the treatment and prevention of metabolic diseases.

show abstract

Developmental exposure to polychlorinated biphenyls (PCBs) in the maternal diet causes host-microbe defects in weanling offspring mice

Cited by 53 publications

References 81 publications

Case-Control Study of the Effects of Gut Microbiota Composition on Neurotransmitter Metabolic Pathways in Children With Attention Deficit Hyperactivity Disorder

Case-Control Study of the Effects of Gut Microbiota Composition on Neurotransmitter Metabolic Pathways in Children With Attention Deficit Hyperactivity Disorder

Toxicomicrobiomics: The Human Microbiome vs. Pharmaceutical, Dietary, and Environmental Xenobiotics

Endocrine Disruptors in Food: Impact on Gut Microbiota and Metabolic Diseases

Contact Info

Product

Resources

About