1988
DOI: 10.1111/j.1432-0436.1988.tb00804.x
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Developmental expression of 44-kDa bone phosphoprotein (osteopontin) and bone γ-carboxyglutamic acid (Gla)-containing protein (osteocalcin) in calcifying tissues of rat

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Cited by 218 publications
(89 citation statements)
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“…5B). The expression domains and intensities of Mmp13 and Opn, which are markers for terminally differentiated hypertrophic chondrocytes at the chondroosseous border (the lowest region of the growth plate) (Chen et al, 1993;Mark et al, 1988;Stickens et al, 2004), were comparable between mutant and control ( Fig. 5C; supplementary material Fig.…”
Section: Impaired Terminal Differentiation Of Hypertrophic Chondrocytmentioning
confidence: 94%
“…5B). The expression domains and intensities of Mmp13 and Opn, which are markers for terminally differentiated hypertrophic chondrocytes at the chondroosseous border (the lowest region of the growth plate) (Chen et al, 1993;Mark et al, 1988;Stickens et al, 2004), were comparable between mutant and control ( Fig. 5C; supplementary material Fig.…”
Section: Impaired Terminal Differentiation Of Hypertrophic Chondrocytmentioning
confidence: 94%
“…First evidence for terminal differentiation of chondrocytes derived from ES cells came from the observation that the nodules lost Alcian blue staining, indicating that matrix components were altered. In addition, the nodules Journal of Cell Science 115 (23) expressed proteins characteristic for hypertrophic and calcifying chondrocytes such as collagen X, osteopontin and bone sialoprotein (Schmid and Linsenmayer, 1985;Mark et al, 1988;Gerstenfeld and Shapiro, 1996). The expression pattern of collagen marker genes during the process of endochondral ossification in vivo (Perälä et al, 1997) was nicely recapitulated during EB cultivation.…”
Section: Es Cells Recapitulate the Process Of Endochondral Ossificationmentioning
confidence: 95%
“…In support of this notion, OC has been previously detected in preosteoblasts in vivo. (47) Second, the physiological counterpart of the NHBC population which lacks both STRO-1 and ALP remains to The discovery of the DNA-binding protein CBFA1 has provided a marker of early osteogenic commitment. (51)(52)(53) CBFA1 is a homolog to the runt family of transcriptional factors and has been specifically associated with osteogenic tissue in rodents.…”
Section: Figmentioning
confidence: 99%