Developmental hematopoietic stem cell variation explains clonal hematopoiesis later in life
Jesse Kreger,
Jazlyn A. Mooney,
Darryl Shibata
et al.
Abstract:Clonal hematopoiesis becomes increasingly common with age, but its cause is enigmatic because driver mutations are often absent. Serial observations infer weak selection indicating variants are acquired much earlier in life with unexplained initial growth spurts. Here we use fluctuating CpG methylation as a lineage marker to track stem cell clonal dynamics of hematopoiesis. We show, via the shared prenatal circulation of monozygotic twins, that weak selection conferred by stem cell variation created before bir… Show more
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