Developmental O‐glycan profile analysis shows pentasaccharide mucin‐type O‐glycans are linked with pupation of Tribolium castaneum

Li, Weidong; Schutter, Kristof De; Damme, Els J.M. Van; Smagghe, Guy

doi:10.1002/arch.21852

Cited by 3 publications

(1 citation statement)

References 38 publications

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“…In D. melanogaster embryos, O-fucosylated glycans comprise 11~16% of the O-glycome (Aoki et al 2008. In contrast to D. melanogaster, T. castaneum embryos carry more O-fucosylated glycans, accounting for 27% of total O-glycome (Li et al 2022). While in the larval and pupal stage of T. castaneum, the fraction is reduced to 13% and 7%, respectively.…”

Section: Insect Speciesmentioning

confidence: 99%

Insights into protein fucosylation in insects

Yang,

De Schutter

2023

entomologia

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Fucosylation, or the attachment of a fucose moiety to a glycan or protein by the action of fucosyltransferases, happens extensively in all living organisms. It plays a vital role in multiple biological processes from development to immunity, and is thought to be highly associated with the occurrence of many human diseases. While the general principles of fucosylation are similar in all organisms, most insects synthesize less processed fucosylated glycans compared to humans. Recent studies in insects show that disruption of fucosylation causes developmental defects leading to lethality, suggesting an essential role in insects. However, because of the limited information available, the molecular mechanisms behind these phenotypes remain unresolved. This review provides an overview on insect fucosylation, including the principle and function of fucosylation, the phylogenesis of the fucosyltransferases, and the diversity and abundance of fucosylated glycans. To provide a better understanding of the different roles of fucosylation in insects, knowledge on fucosylation in mammals or other invertebrates is discussed. As the dynamic requirement for fucosylation in insects needs more research to elucidate the underlying mechanisms, we hope this overview of fucosylation could provide new insights into its role in insects for future studies.

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Section: Insect Speciesmentioning

confidence: 99%

Insights into protein fucosylation in insects

Yang,

De Schutter

2023

entomologia

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Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2021–2022

Harvey

2024

Mass Spectrometry Reviews

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The use of matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this review is the 12th update of the original article published in 1999 and brings coverage of the literature to the end of 2022. As with previous review, this review also includes a few papers that describe methods appropriate to analysis by MALDI, such as sample preparation, even though the ionization method is not MALDI. The review follows the same format as previous reviews. It is divided into three sections: (1) general aspects such as theory of the MALDI process, matrices, derivatization, MALDI imaging, fragmentation, quantification and the use of computer software for structural identification. (2) Applications to various structural types such as oligo‐ and polysaccharides, glycoproteins, glycolipids, glycosides and biopharmaceuticals, and (3) other general areas such as medicine, industrial processes, natural products and glycan synthesis where MALDI is extensively used. Much of the material relating to applications is presented in tabular form. MALDI is still an ideal technique for carbohydrate analysis, particularly in its ability to produce single ions from each analyte and advancements in the technique and range of applications show little sign of diminishing.

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Biosynthesis and Function of Glycoconjugates

Bakar,

Pelin Türker,

Erim

2023

Recent Progress in Pharmaceutical Nanobiotechnology: A Medical Perspective

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Investigations to ascertain the physiological roles of carbohydrates in biological systems are being given more importance each day. Basically, carbohydrates are biomolecules with a wide range of biological functions, although they represent the primary energy source for metabolic processes. Carbohydrates are found as structural components in connective tissue in animal organisms. They also act as structural elements in both plant and bacterial cell walls. In the cell, they bind to lipids and proteins to form glycoconjugates called glycolipids, glycopeptides, glycoproteins and peptidoglycans. By binding to lipids and proteins on the cell surface, they perform as molecules that support intercellular adhesion and intercellular communication. Glycobiology is the science that investigates the structure, biosynthesis, and impacts of glycans on biological functions. In biology, glycoconjugates serve a variety of key roles. In mammalian cells, the majority of proteins are glycosylated, and this explains how proteins perform their various functions. In the future, these techniques will be crucial for the identification and treatment of specific diseases. The most major area of progress in glycobiology is the development of carbohydrate-based medicines. Some diseases, including cancer, can be diagnosed via altered cell surface glycosylation pathways as a biomarker. Therefore, regulating glycosylation mechanisms and understanding the phenotypic characteristics of glycoconjugates are crucial steps in the design of novel strategies. This chapter discusses the biosynthesis of glycoconjugates, their wide range of biological functions, and their significance for therapy

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Developmental O‐glycan profile analysis shows pentasaccharide mucin‐type O‐glycans are linked with pupation of Tribolium castaneum

Cited by 3 publications

References 38 publications

Insights into protein fucosylation in insects

Insights into protein fucosylation in insects

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2021–2022

Biosynthesis and Function of Glycoconjugates

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