Developmental regulation of gene expression in trypanosomatid parasitic protozoa

Haile, Simon; Papadopoulou, Barbara

doi:10.1016/j.mib.2007.10.001

Cited by 187 publications

(179 citation statements)

References 60 publications

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“…The mechanisms that regulate these differentiation steps remain poorly understood (Martinez-Calvillo et al 2010). Because there appears to be virtually no regulation of transcription initiation for protein-coding genes in T. cruzi, the regulation of their expression is thought to depend mainly on post-transcriptional processes (Clayton & Shapira 2007, Haile & Papadopoulou 2007. The mature mRNAs are derived from polycistronic transcripts that are produced at relatively constant levels (except for occasional genomic copy amplification) and are regulated at the level of degradation, localisation or translation via untranslated region signals and RNA-binding proteins (Kramer & Carrington 2011).…”

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confidence: 99%

The overexpression of the trypanosomatid-exclusive TcRBP19 RNA-binding protein affects cellular infection by Trypanosoma cruzi

Pérez-Díaz¹,

Correa

Moretão

et al. 2012

Mem. Inst. Oswaldo Cruz

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To characterise the trypanosomatid-exclusive RNA-binding protein TcRBP19, we analysed the phenotypic changes caused by its overexpression. Although no evident changes were observed when TcRBP19 was ectopically expressed in epimastigotes, the metacyclogenesis process was affected. Notably, TcRBP19 overexpression also led to a decrease in the number of infected mammalian cells. These findings suggest that TcRBP19 may be involved in the life cycle progression of the Trypanosoma cruzi parasite

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confidence: 99%

The overexpression of the trypanosomatid-exclusive TcRBP19 RNA-binding protein affects cellular infection by Trypanosoma cruzi

Pérez-Díaz¹,

Correa

Moretão

et al. 2012

Mem. Inst. Oswaldo Cruz

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“…Una explicación lógica de las diferencias en el nivel de aumento de expresión detectado por ambas técnicas, puede ser que la traducción de proteínas en Leishmania spp. no conserva una relación lineal con la transcripción de ARNm debido a los diferentes mecanismos de regulación postranscripcionales que existen en este parásito (43)(44)(45).…”

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Expresión diferencial de proteínas en Leishmania (Viannia) panamensis asociadas con mecanismos de resistencia a antimoniato de meglumina

et al. 2012

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“…The polypyrimidine track of a given gene is also responsible for directing the polyadenylation site of the upstream mRNA [20]. Therefore, control of gene expression is post-transcriptionally regulated by downstream events affecting mRNA stability and translation [23][24][25].…”

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Using Genomic Information to Understand Leishmania Biology

Toledo¹

2010

TOPARAJ

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Abstract:The genomes of different species of Leishmania have been deciphered in recent years. We learned that the genome content and organization of Leishmania major, Leishmania braziliensis and Leishmania infantum are highly similar and annotation of these genomes revealed that there are few species-specific genes. Association of genome information with reverse and forward genetics approaches allows posing and answering relevant biological questions in a novel way. In this article we briefly present an overview of relevant aspects of genome organization of the Leishmania and how this information can be used to improve our understanding of the biology, pathogenesis, host-parasite interaction issues. We present some of the most useful bioinformatics tools/softwares, which are currently available and how each one of them can be used to explore the genome supporting a wide variety of queries. We included other computational tools which allow integrating the genome data with biochemical pathways revealing metabolic and regulatory networks to be investigated. Finally, we discuss reverse and forward genetic tools available and finalize with considerations on established and novel high-throughput approaches at the genome, transcriptome and proteome levels.

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Developmental regulation of gene expression in trypanosomatid parasitic protozoa

Cited by 187 publications

References 60 publications

The overexpression of the trypanosomatid-exclusive TcRBP19 RNA-binding protein affects cellular infection by Trypanosoma cruzi

The overexpression of the trypanosomatid-exclusive TcRBP19 RNA-binding protein affects cellular infection by Trypanosoma cruzi

Expresión diferencial de proteínas en Leishmania (Viannia) panamensis asociadas con mecanismos de resistencia a antimoniato de meglumina

Using Genomic Information to Understand Leishmania Biology

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