Developmental signals control chromosome segregation fidelity during pluripotency and neurogenesis by modulating replicative stress
Anchel de Jaime-Soguero,
Janina Hattemer,
Anja Bufe
et al.
Abstract:Human development relies on the correct replication, maintenance and segregation of our genetic blueprints. How these processes are monitored across embryonic lineages, and why genomic mosaicism varies during development remain unknown. Using pluripotent stem cells, we identify that several patterning signals—including WNT, BMP, and FGF—converge into the modulation of DNA replication stress and damage during S-phase, which in turn controls chromosome segregation fidelity in mitosis. We show that the WNT and BM… Show more
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