Developmental toxicity of TCBPA on the nervous and cardiovascular systems of zebrafish (Danio rerio): A combination of transcriptomic and metabolomics

Li, Wentao; Pan, Yifan; Yang, Lu; Xie, Yun; Chen, Xuanyue; Chang, Jing; Wang, Hao; Zhu, Lifei; Wan, Bin

doi:10.1016/j.jes.2022.04.022

Cited by 29 publications

(6 citation statements)

References 75 publications

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“…Metabolomics plays an essential role in toxicological research by providing a detailed analysis of altered metabolic pathways that are targeted by harmful chemicals [163][164][165].…”

Section: Toxicity Assessmentmentioning

confidence: 99%

Review on analytical technologies and applications in metabolomics

MENG,

LIU,

et al. 2024

BIOCELL

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Over the past decade, the swift advancement of metabolomics can be credited to significant progress in technologies such as mass spectrometry, nuclear magnetic resonance, and multivariate statistics. Currently, metabolomics garners widespread application across diverse fields including drug research and development, early disease detection, toxicology, food and nutrition science, biology, prescription, and chinmedomics, among others.Metabolomics serves as an effective characterization technique, offering insights into physiological process alterations in vivo. These changes may result from various exogenous factors like environmental conditions, stress, medications, as well as endogenous elements including genetic and protein-based influences. The potential scientific outcomes gleaned from these insights have catalyzed the formulation of innovative methods, poised to further broaden the scope of this domain. Today, metabolomics has evolved into a valuable and widely accepted instrument in the life sciences. However, comprehensive reviews focusing on the sample preparation and analytical methodologies employed in metabolomics within the life sciences are surprisingly scant. This review aims to fill that gap, providing an overview of current trends and recent advancements in metabolomics. Particular emphasis is placed on sample preparation, sophisticated analytical techniques, and their applications in life science research.

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“…Metabolomics plays an essential role in toxicological research by providing a detailed analysis of altered metabolic pathways that are targeted by harmful chemicals [163][164][165].…”

Section: Toxicity Assessmentmentioning

confidence: 99%

Review on analytical technologies and applications in metabolomics

MENG,

LIU,

et al. 2024

BIOCELL

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“…Zebrafish is the best and promising high‐throughput vertebrate screening model for assessing environmental toxicants. According to 16 research reports on novel pollutants published in 2022, their developmental toxicity indicators include reduced hatching rates (Gao et al, 2022; Lu, Lv, Kou, et al, 2022; Shi, Qian, et al, 2022; Teng et al, 2022; Wang, Ma, Ding, et al, 2022, Wang, Wang, Wang, et al, 2022; Zhang, Guo, et al, 2022, Zhang, Zhao, et al, 2022), survival rates (Fan, Dai, et al, 2022; Liu, Pan, et al, 2022; Lu, Lv, Kou, et al, 2022), body weight (Lu, Lv, Kou, et al, 2022; Zhang, Zhao, et al, 2022), body length (Chen, Yang, et al, 2022, Chen, Xiao, et al, 2022; Fan, Dai, et al, 2022; Liu, Pan, et al, 2022; Lu, Lv, Kou, et al, 2022; Teng et al, 2022; Wang, Ma, Ding, et al, 2022; Zhang, Zhao, et al, 2022), and heart rate (Chen, Xiao, et al, 2022; Fan, Dai, et al, 2022; Gao et al, 2022; Hua et al, 2022; Teng et al, 2022; Yu, Cheng, et al, 2022; Zhang, Guo, et al, 2022); increased mortality rate (Chen, Xiao, et al, 2022; Wang, Ma, Ding, et al, 2022, Wang, Wang, Wang, et al, 2022; Zhang, Guo, et al, 2022, Zhang, Zhao, et al, 2022) and malformation rate (Chen, Yang, et al, 2022; De Marco et al, 2022; Fan, Dai, et al, 2022; Gao et al, 2022; Liu, Pan, et al, 2022; Lu, Lv, Kou, et al, 2022; Shi, Qian, et al, 2022; Wang, Ma, Ding, et al, 2022; Zhang, Guo, et al, 2022, Zhang, Zhao, et al, 2022); and altered motor behavior (Chen, Xiao, et al, 2022; Fan, Dai, et al, 2022; Gao et al, 2022; Hua et al, 2022; Santos, Barreto, et al, 2022; Teng et al, 2022; Wang, Ma, Ding, et al, 20...…”

Section: Developmental Toxicity In Zebrafishmentioning

confidence: 99%

“…Lu, Lv, Kou, et al, 2022;Shi, Qian, et al, 2022;Teng et al, 2022;Wang, Ma, Ding, et al, 2022Zhang, Guo, et al, 2022, survival rates(Fan, Dai, et al, 2022;Liu, Pan, et al, 2022;Lu, Lv, Kou, et al, 2022), body weight(Lu, Lv, Kou, et al, 2022;Zhang, Zhao, et al, 2022), body length, Chen, Xiao, et al, 2022Fan, Dai, et al, 2022;Liu, Pan, et al, 2022;Lu, Lv, Kou, et al, 2022;Teng et al, 2022;Wang, Ma, Ding, et al, 2022;Zhang, Zhao, et al, 2022), and heart rate(Chen, Xiao, et al, 2022;Fan, Dai, et al, 2022;Gao et al, 2022;Hua et al, 2022;Teng et al, 2022;Yu, Cheng, et al, 2022;Zhang, Guo, et al, 2022); increased mortality rate(Chen, Xiao, et al, 2022;Wang, Ma, Ding, et al, 2022Zhang, Guo, et al, 2022 and malformation rateDe Marco et al, 2022;Fan, Dai, et al, 2022;Gao et al, 2022;Liu, Pan, et al, 2022;Lu, Lv, Kou, et al, 2022;Shi, Qian, et al, 2022;Wang, Ma, Ding, et al, 2022;Zhang, Guo, et al, 2022; and altered motor behavior(Chen, Xiao, et al, 2022;Fan, Dai, et al, 2022;…”

mentioning

confidence: 99%

Frontier of toxicology studies in zebrafish model

Shao,

Xiao,

Yang

et al. 2023

J of Applied Toxicology

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Based on the 87 original publications only from quartiles 1 and 2 of Journal Citation Report (JCR) collected by the major academic databases (Science Direct, Web of Science, PubMed, and Wiley) in 2022, the frontier of toxicology studies in zebrafish model is summarized. Herewith, a total of six aspects is covered such as developmental, neurological, cardiovascular, hepatic, reproductive, and immunizing toxicities. The tested samples involve chemicals, drugs, new environmental pollutants, nanomaterials, and its derivatives, along with those related mechanisms. This report may provide a frontier focus benefit to researchers engaging in a zebrafish model for environment, medicine, food, and other fields.

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“…Various studies have evaluated the toxicological effects of TCBPA using in vitro and Am J Cancer Res 2024;14(3):1363-1375 in vivo models; these studies have indicated its potential for endocrine disruption, cytotoxicity, liver toxicity, and neurotoxicity [8]. For example, using zebrafish as an aquatic model organism, research has found that TCBPA has toxic effects on the cardiovascular and nervous systems of zebrafish [9]. Further, Wang et al reported that TCBPA caused immunosuppression in a mouse model [7].…”

Section: Introductionmentioning

confidence: 99%

Different effects of TCBPA exposure on liver cancer cells and liver cells: two sides of the coin

Wang

2024

Am J Cancer Res

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Tetrachlorobisphenol A (TCBPA), widely used as a substitute for tetrabromobisphenol A (TBBPA), has been detected in various environmental media. Therefore, a detailed evaluation of the toxicological properties of TCBPA is necessary. In this study, we used hepatoma and normal liver cell models in vitro to investigate the effects of TCBPA.Our findings indicate that TCBPA promotes the proliferation of liver cancer cells, as evidenced by MTT and EdU assays, and enhances the expression levels of molecules related to hepatoma proliferation. Further investigation into the molecular mechanism revealed that TCBPA-induced hepatoma proliferation is regulated by an NLRP3-mediated inflammatory process. Additionally, TCBPA was found to promote the epithelial-mesenchymal transition (EMT) process in liver cancer cells. Conversely, TCBPA inhibited the proliferation of normal liver cells. Mechanistic studies showed that TCBPA induced cell pyroptosis in normal liver cells by evaluating a series of related markers, including NLRP3, IL-1β, ASC, GASDMD, and Caspase 1. In vivo models further showed that TCBPA causes liver tissue damage. In summary, this study demonstrates that TCBPA has a dual effect: promoting the occurrence and development of liver tumor cells in vitro, while inhibiting the proliferation of normal liver cells, like two sides of a coin. These opposite cellular outcomes are regulated by NLRP3-mediated inflammatory processes, providing valuable insights for evaluating the potential health impacts of TCBPA.

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Developmental toxicity of TCBPA on the nervous and cardiovascular systems of zebrafish (Danio rerio): A combination of transcriptomic and metabolomics

Cited by 29 publications

References 75 publications

Review on analytical technologies and applications in metabolomics

Review on analytical technologies and applications in metabolomics

Frontier of toxicology studies in zebrafish model

Different effects of TCBPA exposure on liver cancer cells and liver cells: two sides of the coin

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