Developments in the Surgical Approach to Staging and Resection of Rhabdomyosarcoma

Scheltinga, Sheila Terwisscha van; Rogers, Timothy; Smeulders, Naima; deCorti, Federica; Guérin, Florent; Craigie, Ross; Burrieza, Gabriela Guillén; Smeele, Ludi E.; Hol, M.; Rijn, Rick R. van; Fuchs, Joerg; Seitz, Guido; Schmidt, Andreas; Timmermann, Beate; Tunn, Per‐Ulf; Chargari, Cyrus; Fajardo, Raquel Dávila; Slater, Olga; Gains, J.; Merks, Johannes H. M.

doi:10.3390/cancers15020449

Cited by 6 publications

(6 citation statements)

References 101 publications

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“…Surgery is often considered to be the preferred local treatment option, but feasibility can be challenging due to many variables such as tumour size and local extent. 14 , 15 The clinical approach is particularly complex in specific tumour sites. A good example is RMS arising in a parameningeal site.…”

Section: Introductionmentioning

confidence: 99%

Clinical Insight on Proton Therapy for Paediatric Rhabdomyosarcoma

Vennarini,

Colombo,

Mirandola

et al. 2023

CMAR

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This paper offers an insight into the use of Proton Beam Therapy (PBT) in paediatric patients with rhabdomyosarcoma (RMS). This paper provides a comprehensive analysis of the literature, investigating comparative photon-proton dosimetry, outcome, and toxicity. In the complex and multimodal scenario of the treatment of RMS, clear evidence of the therapeutic superiority of PBT compared to other modern photon techniques has not yet been demonstrated; however, PBT can be considered an excellent treatment option, in particular for young children and patients with specific primary sites, such as the head and neck area (and especially the parameningeal regions), genito-urinary, pelvic, and paravertebral regions. The unique depth-dose characteristics of protons can be exploited to achieve significant reductions in normal tissue doses and may allow an escalation of tumour doses and greater sparing of normal tissues, thus potentially improving local control while at the same time reducing toxicity and improving quality of life. However, access of children with RMS (and more in general with solid tumors) to PBT remains a challenge, due to the limited number of available proton therapy installations.

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Section: Introductionmentioning

confidence: 99%

Clinical Insight on Proton Therapy for Paediatric Rhabdomyosarcoma

Vennarini,

Colombo,

Mirandola

et al. 2023

CMAR

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“…Childhood solid tumour malignancies such as Wilm’s tumour and neuroblastoma have 5-year survival rates now approaching 92 and 60% respectively 250–252 . Success steadily continues with many other solid tumours, notably germ cell tumours and sarcomas, whilst other rare tumours such as aggressive primitive neuroectodermal neoplasms as a key noteworthy example may have variably poor outcomes, with less than 40% survival despite current therapies 253–257 . The defining role of surgery in the curative treatment of many childhood tumours links with individual patient risk staging categorization and biology.…”

Section: Cancermentioning

confidence: 99%

Major surgical conditions of childhood and their lifelong implications: comprehensive review

Cullis,

Fouad,

Goldstein

et al. 2024

BJS Open

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Background In recent decades, the survival of children with congenital anomalies and paediatric cancer has improved dramatically such that there has been a steady shift towards understanding their lifelong health outcomes. Paediatric surgeons will actively manage such conditions in childhood and adolescence, however, adult surgeons must later care for these ‘grown-ups’ in adulthood. This article aims to highlight some of those rare disorders encountered by paediatric surgeons requiring long-term follow-up, their management in childhood and their survivorship impact, in order that the adult specialist may be better equipped with skills and knowledge to manage these patients into adulthood. Methods A comprehensive literature review was performed to identify relevant publications. Research studies, review articles and guidelines were sought, focusing on the paediatric management and long-term outcomes of surgical conditions of childhood. The article has been written for adult surgeon readership. Results This article describes the aforementioned conditions, their management in childhood and their lifelong implications, including: oesophageal atresia, tracheo-oesophageal fistula, malrotation, short bowel syndrome, duodenal atresia, gastroschisis, exomphalos, choledochal malformations, biliary atresia, Hirschsprung disease, anorectal malformations, congenital diaphragmatic hernia, congenital lung lesions and paediatric cancer. Conclusion The increasing survivorship of children affected by surgical conditions will translate into a growing population of adults with lifelong conditions and specialist healthcare needs. The importance of transition from childhood to adulthood is becoming realized. It is hoped that this timely review will enthuse the readership to offer care for such vulnerable patients, and to collaborate with paediatric surgeons in providing successful and seamless transitional care.

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“…The scope of surgery has now evolved from extensive to limited, and conservative resection has provided adequate local control [2,8,12,13]. The IRSG recommends low-intensity surgical resection combined with chemotherapy to treat uterine RMS [14].…”

Section: Treatment Of Cervical Rmsmentioning

confidence: 99%