Device-based controlled local delivery of anastrozol into peritoneal cavity: in vitro and in vivo evaluation

Krier, Fabrice; Riva, Raphaël; Defrère, Sylvie; Mestdagt, Mélanie; Langendonckt, Anne Van; Drion, Pierre; Dehoux, Jean‐Paul; Donnez, J; Foidart, Jean‐Michel; Jérôme, Christine; Évrard, Brigitte

doi:10.1016/s1773-2247(14)50032-9

Cited by 5 publications

(1 citation statement)

References 16 publications

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“…A homemade mold allowing light irradiation at 60 °C has been designed to prevent the formation of an irregular surface during UV irradiation and ensure reproducibility. The template containing the PCL sample was sandwiched between two films made of cross-linked polydimethylsiloxane (PDMS) (the synthesis of the PDMS membranes is reported elsewhere 34 ), preventing the adhesion of cross-linked PCL to the quartz plates used to provide rigidity, which are both transparent to UV irradiation. The system was then fixed with four clamps to maintain together the different parts and placed under UV irradiation at 365 nm in a ventilated oven at 60 °C.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

Photo-Cross-Linkable Coumarin-Based Poly(ε-caprolactone) for Light-Controlled Design and Reconfiguration of Shape-Memory Polymer Networks

et al. 2018

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Photochemically cross-linked shape-memory polymer (SMP) materials have been achieved by functionalizing chain-ends of star-shaped poly(ε-caprolactone) (PCL) with 7-hydroxypropoxy-4-methylcoumarin followed by photodimerization of these end-groups. The kinetics of the network formation in function of the photosensitizer concentration has been studied by swelling experiments and rheology. Thanks to the design of a dedicated homemade mold, highly reproducible irradiation conditions have been achieved allowing to study the network formation and properties, especially the shapememory properties, in relation to the coumarin dimerization degree as determined by Raman spectroscopy. In optimized conditions, PCL-based SMP materials exhibiting high fixity and recovery have been achieved in remarkably short irradiation time, typically 5 min. In addition, the precise control of the network cross-link density with the irradiation time, so as the high stability of the formed networks toward temperature variations was also demonstrated allowing the fine-tuning of the network properties by the irradiation process. Finally, the reversible character of the coumarin dimerization under light irradiation of appropriate wavelength has been quantified by Raman spectroscopy. The dimer photocleavage allows the photoreconfiguration of the networks offering the ability to modify the "permanent" shape of the SMP material, while preserving the excellent shape-memory properties.

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Section: ■ Experimental Sectionmentioning

confidence: 99%

Photo-Cross-Linkable Coumarin-Based Poly(ε-caprolactone) for Light-Controlled Design and Reconfiguration of Shape-Memory Polymer Networks

et al. 2018

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Peritoneal Implants and Drug Delivery

Syed,

Irfan,

Zahoor

et al. 2023

Exploring Drug Delivery to the Peritoneum

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Comparing human peritoneal fluid and phosphate-buffered saline for drug delivery: do we need bio-relevant media?

Bhusal

Rahiri

Su’a

et al. 2018

Drug Deliv. and Transl. Res.

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An understanding of biological fluids at the site of administration is important to predict the fate of drug delivery systems in vivo. Little is known about peritoneal fluid; therefore, we have investigated this biological fluid and compared it to phosphate-buffered saline, a synthetic media commonly used for in vitro evaluation of intraperitoneal drug delivery systems. Human peritoneal fluid samples were analysed for electrolyte, protein and lipid levels. In addition, physicochemical properties were measured alongside rheological parameters. Significant inter-patient variations were observed with regard to pH (p < 0.001), buffer capacity (p < 0.05), osmolality (p < 0.001) and surface tension (p < 0.05). All the investigated physicochemical properties of peritoneal fluid differed from phosphate-buffered saline (p < 0.001). Rheological examination of peritoneal fluid demonstrated non-Newtonian shear thinning behaviour and predominantly exhibited the characteristics of an entangled network. Inter-patient and inter-day variability in the viscosity of peritoneal fluid was observed. The solubility of the local anaesthetic lidocaine in peritoneal fluid was significantly higher (p < 0.05) when compared to phosphate-buffered saline. Interestingly, the dissolution rate of lidocaine was not significantly different between the synthetic and biological media. Importantly, and with relevance to intraperitoneal drug delivery systems, the sustained release of lidocaine from a thermosensitive gel formulation occurred at a significantly faster rate into peritoneal fluid. Collectively, these data demonstrate the variation between commonly used synthetic media and human peritoneal fluid. The differences in drug release rates observed illustrate the need for bio-relevant media, which ultimately would improve in vitro-in vivo correlation.

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Device-based controlled local delivery of anastrozol into peritoneal cavity: in vitro and in vivo evaluation

Cited by 5 publications

References 16 publications

Photo-Cross-Linkable Coumarin-Based Poly(ε-caprolactone) for Light-Controlled Design and Reconfiguration of Shape-Memory Polymer Networks

Photo-Cross-Linkable Coumarin-Based Poly(ε-caprolactone) for Light-Controlled Design and Reconfiguration of Shape-Memory Polymer Networks

Peritoneal Implants and Drug Delivery

Comparing human peritoneal fluid and phosphate-buffered saline for drug delivery: do we need bio-relevant media?

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