In this paper, we study D2D (Device-to-Device) communication underlying LTE-Advanced uplink system. Since D2D communication reuses uplink resources with cellular communication in this scenario, it's hard for D2D users to avoid the interference from cellular users while cellular users are communication with eNB (evolved Node B). HARQ (Hybrid Automatic Repeat reQuest) is widely used in LTE-Advanced system in order to improve the accurate rate of cellular communication. Hence, we consider studying the integration of D2D with HARQ, so as to achieve the purpose of improving the throughput of D2D communication and the performance of overall system. Synchronous HARQ is considered to introduce into D2D communication procedures. What's more, this idea will be taken into system-level simulation. From the simulation results, we can see that the throughput of D2D communication gets a lot of gain and the performance of overall system is improved as well. In addition, Synchronous HARQ technique can significantly decrease the BLER (Block Error Rate) of D2D communication, especially for which in a bad channel condition.