The article aims to determine the influence of the innovation potential of personnel on strengthening economic security of Ukrainian enterprises in the post-war period. The object of the article is the process of strengthening economic security of Ukrainian enterprises considering the use of innovation potential of their personnel. The study uses general scientific theoretical methods: generalization, explanation, grouping - to analyze economists’ views of the study object and draw conclusions of the content analysis of primary sources, analysis and synthesis - to clarify the main scientific categories of the study, substantiate new conceptual provisions. Four obstacles have been identified to the positive influence of the innovation potential of personnel on strengthening economic security which consist in the absence of an innovative component in the advanced training program for personnel of most Ukrainian companies and government institutions; an indicator related to the innovation potential of personnel in the regulatory legal acts of Ukraine on innovative development; joint projects of the state and private partners to increase the innovation potential of personnel; a relevant state body that would deal with strategic issues of cooperation with business structures and other private enterprises. The article proposes directions of solving the identified problems. The proposed directions are of scientific novelty and practical value and can be used in development of joint projects to strengthen economic security in the energy sector, construction, import substitution and other fields. Consideration of innovative competences, technical and professional potential will allow solving the issues of combating terrorism, cybercrime, protecting critical infrastructure, eliminating consequences of emergencies and environmental disasters, restoring activities of enterprises in various sectors of the economy.