Dexamethasone and diclofenac intramuscular mixture injection and risk of death: A case series study

Naser, Abdallah Y; Qadus, Sami; Alwafi, Hassan; Jarrar, Qais; Ayoub, Rami; Jaradat, Abdolelah; Atiyah, Riyadh Mohammed; Alqaisy, Abdulrahman Ibrahim

doi:10.1002/ccr3.3988

Cited by 2 publications

(1 citation statement)

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“…The results obtained demonstrated that 0.32 mg/mL EO and 12.5 µg/mL HRW decrease NO levels by 58.85% and 31.11% in LPS-treated cells, respectively, in comparison with cells exposed to LPS alone ( Figure 3 ). Dexamethasone and diclofenac are commonly used drugs for anti-inflammatory and analgesic purposes [ 44 ]. However, it is not possible to compare the anti-inflammatory activity of EO and HRW extracts—which are a mixture of several bioactive molecules—with those of pure chemicals such as dexamethasone or diclofenac, as the concentrations are not in the same range.…”

Section: Resultsmentioning

confidence: 99%

Chemical Composition and Effect against Skin Alterations of Bioactive Extracts Obtained by the Hydrodistillation of Eucalyptus globulus Leaves

et al. 2022

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Eucalyptus globulus is planted extensively for pulp, paper and wood production. Although bioactive compounds obtained from its biomass are used as cosmetics ingredients, the skin effects were not yet fully explored. In order to fill this gap, this work aimed to study the protective effect against skin damage provided by the essential oil (EO) obtained from the hydrodistillation of Eucalyptus globulus leaves, and by an extract obtained from the hydrodistillation residual water (HRW). The major compound identified in the EO was 1,8-Cineole, and the phenolic acids in the HRW included gallic acid as the main phenolic constituent. Moreover, non-toxic EO and HRW concentrations were shown to have anti-aging skin effects in vitro, decreasing age-related senescence markers, namely β-galactosidase and matrix metalloproteinases activation, as well as collagen type 1 upregulation. In addition, EO and HRW were found to exhibit depigmenting effects by inhibiting tyrosinase and melanin production, along with potent anti-inflammatory properties. Furthermore, the absence of skin irritation and sensitization in cells exposed to EO and HRW revealed the safety of both extracts for topical use. Taken together, these results highlight the beneficial effects of extracts obtained from Eucalyptus globulus biomass for skin aesthetic and health purposes, which should be explored deeply for the prediction of future pharmaceutical and dermocosmetics industrial applications.

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Section: Resultsmentioning

confidence: 99%