Dexamethasone- loaded polymeric porous sponge as a direct pulp capping agent

Alagha, Amjad; Nourallah, Abdulwahab; Al-Hariri, Sahar

doi:10.1080/09205063.2020.1769801

Cited by 7 publications

(6 citation statements)

References 73 publications

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“…The increase in the release due to the higher amounts of u-PPO2000 precursor can be explained by two factors: first, its hydrophobic character, as the u-PPO400 has a lower molecular weight compared to u-PPO2000, explaining the low affinity with the environment; second, the membranes with a higher proportion of u-PPO400 material present higher rigidity (many siloxane groups), decreasing the ability of relaxation and swelling, as observed in the results of swelling [ 23 , 24 , 25 , 26 , 27 ], explaining the greater or lesser ability of the material to swell and the process of diffusion of the environment to occur, a fact observed in the difference in detection time of DMA.…”

Section: Resultsmentioning

confidence: 99%

Dexamethasone-Loaded Ureasil Hydrophobic Membrane for Bone Guided Regeneration

et al. 2022

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Physical barrier membranes have been used to release active substances to treat critical bone defects; however, hydrophilic membranes do not present a prolonged release capacity. In this sense, hydrophobic membranes have been tested. Thus, this study aimed to develop hydrophobic membranes based on mixtures of ureasil–polyether-type materials containing incorporated dexamethasone (DMA) for the application in guided bone regeneration. The physicochemical characterization and biological assays were carried out using small-angle X-ray scattering (SAXS), an in vitro DMA release study, atomic force microscopy (AFM), a hemolysis test, and in vivo bone formation. The swelling degree, SAXS, and release results revealed that the u-PPO400/2000 membrane in the proportion of 70:30 showed swelling (4.69% ± 0.22) similar to the proportions 90:10 and 80:20, and lower than the proportion 60:40 (6.38% ± 0.49); however, an equal release percentage after 134 h was observed between the proportions 70:30 and 60:40. All u-PPO materials presented hemocompatibility (hemolysis ≤2.8%). AFM results showed that the treatments with or without DMA did not present significant differences, revealing a flat/smooth surface, with no pores and/or crystalline precipitates. Finally, in vivo results revealed that for both the commercial hydrophilic membrane and u-PPO400/2000 (70:30) after 60 days, the bone formation volume was 21%. In conclusion, hybrid membranes present unique characteristics for treating critical bone defects, considering the delayed and prolonged release results associated with the physical barrier capacity.

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Section: Resultsmentioning

confidence: 99%

Dexamethasone-Loaded Ureasil Hydrophobic Membrane for Bone Guided Regeneration

et al. 2022

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“…In a later study, the hierarchical and dynamic structure of the natural ECM was mimicked by using multiscale or micronanofibers for the fabrication of the membrane. Electrospun membranes are considered as 2D structures and thus are generally incapable of mimicking the infiltration characteristics of a native tissue, but this modification proved to be an improvement, noticed through the enhanced infiltration and proliferation of the cells . Electrospinning not only allows for multiscale fibers but also possesses the ability to print different fibers in a coaxial fashion.…”

Section: Physical and Chemical Characteristics Of Bioartificial Membr...mentioning

confidence: 99%

“…Electrospun membranes are considered as 2D structures and thus are generally incapable of mimicking the infiltration characteristics of a native tissue, but this modification proved to be an improvement, noticed through the enhanced infiltration and proliferation of the cells. 75 Electrospinning not only allows for multiscale fibers but also possesses the ability to print different fibers in a coaxial fashion. Controlling the alignment of the sheath and core of the membrane allowed for the replication of cartilage tissue 76 ( Figure 4 c,d).…”

Section: Physical and Chemical Characteristics Of Bioartificial Membr...mentioning

confidence: 99%

Surface Engineering of a Bioartificial Membrane for Its Application in Bioengineering Devices

et al. 2023

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Membrane technology is playing a crucial role in cutting-edge innovations in the biomedical field. One such innovation is the surface engineering of a membrane for enhanced longevity, efficient separation, and better throughput. Hence, surface engineering is widely used while developing membranes for its use in bioartificial organ development, separation processes, extracorporeal devices, etc. Chemical-based surface modifications are usually performed by functional group/biomolecule grafting, surface moiety modification, and altercation of hydrophilic and hydrophobic properties. Further, creation of micro/nanogrooves, pillars, channel networks, and other topologies is achieved to modify physio-mechanical processes. These surface modifications facilitate improved cellular attachment, directional migration, and communication among the neighboring cells and enhanced diffusional transport of nutrients, gases, and waste across the membrane. These modifications, apart from improving functional efficiency, also help in overcoming fouling issues, biofilm formation, and infection incidences. Multiple strategies are adopted, like lysozyme enzymatic action, topographical modifications, nanomaterial coating, and antibiotic/antibacterial agent doping in the membrane to counter the challenges of biofilm formation, fouling challenges, and microbial invasion. Therefore, in the current review, we have comprehensibly discussed different types of membranes, their fabrication and surface modifications, antifouling/ antibacterial strategies, and their applications in bioengineering. Thus, this review would benefit bioengineers and membrane scientists who aim to improve membranes for applications in tissue engineering, bioseparation, extra corporeal membrane devices, wound healing, and others.

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“…In an animal experiment, they compared this scaffold with calcium hydroxide. They showed that dexamethasone-releasing scaffolds stimulated dentin bridge formation faster than the calcium hydroxide group without the inflammatory response in the pulp [68].…”

Section: Scaffold-based Strategiesmentioning

confidence: 99%

Approaches to vital pulp therapies

Ballıkaya

Çelebi‐Saltik

2023

Aust Endodontic J

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Tooth decay, which leads to pulpal inflammation due to the pulp’s response to bacterial components and byproducts is the most common infectious disease. The main goals of clinical management are to eliminate sources of infection, to facilitate healing by regulating inflammation indental tissue, and to replace lost tissues. A variety of novel approaches from tissue engineering based on stem cells, bioactive molecules, and extracellular matrix‐like scaffold structures to therapeutic applications, or a combination of all these are present in the literature. Shortcomings of existing conventional materials for pulp capping and the novel approches aiming to preserve pulp vitality highligted the need for developing new targeted dental materials. This review looks at the novel approches for vital pulp treatments after briefly addresing the conventional vital pulp treatment as well as the regenerative and self defense capabilities of the pulp. A narrative review focusing on the current and future approaches for pulp preservation was performed after surveying the relevant papers on vital pulp therapies including pulp capping, pulpotomy, and potential approaches for facilitating dentin‐pulp complex regeneration in PubMed, Medline, and Scopus databases.

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Dexamethasone- loaded polymeric porous sponge as a direct pulp capping agent

Cited by 7 publications

References 73 publications

Dexamethasone-Loaded Ureasil Hydrophobic Membrane for Bone Guided Regeneration

Dexamethasone-Loaded Ureasil Hydrophobic Membrane for Bone Guided Regeneration

Surface Engineering of a Bioartificial Membrane for Its Application in Bioengineering Devices

Approaches to vital pulp therapies

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