Dexamethasone reduces bronchial wall remodeling during pulmonary migration of Strongyloides venezuelensis larvae in rats

Hyperinfection Syndrome in Strongyloidiasis

“…IgG and IgM can transfer immunity against the human parasite in the presence of the complement system and neutrophils (Abraham et al, 1995;Vadlamudi et al, 2006) Laboratory models have suggested that both T and B cells mediate the immune response through an increase in immunoglobulins, eosinophils and mast cells and hyperplasia of goblet cells, which require interleukins and chemokines for their development and activation. In strongyloidiasis, dexamethasone seems to primarily suppress cytokines such as IL-1 , IL-4, VEGF, TNF-, IFN-, IL-3, IL-4, IL-5, IL-10 and IL-12 and decreases the production of IgG and IgE antibodies during S. venezuelensis infection (Machado et al, 2011;Tefé-Silva et al, 2012).…”

“…In contrast, immunosuppression with dexamethasone interferes with the pulmonary cycle of Strongyloides venezuelensis infection and promotes greater haemorrhage, which is provoked by the substantial quantities of larvae that pass into the alveolar spaces, accompanied by a decrease in eosinophil and mast cell migration and impaired formation of granulomas (Tefé-Silva et al, 2008). In addition, dexamethasone treatment inhibited airway remodelling, contributing to the dissemination of the parasite (Tefé-Silva et al, 2012). In the small intestine of rodents infected with S. venezuelensis, females and fertile eggs were observed in the wall of the gastrointestinal tract and invading the intestinal mucosa, with increased inflammatory exudate and eosinophils (Machado et al, 2005).…”

Imunodiagnóstico da estrongiloidíase humana frente a diferentes frações antigênicas de Strongyloides venezuelensis

“…Strongyloides spp, infecções em modelos experimentais, sobretudo em ratos, vêm sendo realizadas. As espécies S. ratti e S. venezuelensis têm se consolidado como importante ferramenta para o estudo de antígenos heterólogos em testes imunológicos (Costa-Silva et al, 2003;Gonçalves et al, 2012b) e em estudos sobre a modulação do sistema imune(Negrão-Corrêa et al, 2006;Machado et al, 2011;Tefé-Silva et al, 2012).…”